Professor, Organic/Medicinal Chemistry
1720 2nd Avenue South
Birmingham, AL 35294-4400
Dr. Brouillette's Publications
Lab Research Focus: Protein Structural Cooperatively and Energetics
My research interests are in the area of protein structural cooperativity and energetics, through the application of biophysical techniques to study native and engineered proteins and protein-ligand interactions. I have three research programs: Apolipoprotein A-I Structure and Function, Protein Structural Thermodynamics, and Antibacterial Drug Discovery. A major thrust of my research involves using thermodynamic approaches to dissect the energetics of ligand receptor interactions to define the importance of specific functional groups to overall affinity and conformational changes. Some research projects are very basic, and others are applied directly to drug development.Biography
Dr. Brouillette is a Research Professor in the Department of Chemistry, a secondary faculty member in the Department of Biochemistry and Molecular Genetics. She also serves as Associate Director, Molecular Biophysics, in the Center for Biophysical Sciences and Engineering. She received her doctorate from the University of Kansas in Medicinal Chemistry in 1979. Dr. Brouillette's research is supported by grants from NIH, NASA, and pharmaceutical industry.