Professor, Biophysical ChemistryUAB Department of Chemistry
1530 3rd Avenue South
Birmingham AL, 35294-1240
Professor (b. 1950.) obtained his B.S. degree in biophysics at the Ohio State University (1973). Under the direction of Joseph Y. Cassim, he received his Ph.D. degree in molecular biophysics at the Ohio State University (1979) where he used CD spectroscopy to study the membrane protein bacteriorhodopsin. Dr. Muccio was a NIH postdoctoral student in the Department of Chemistry at Case Western Reserve University where he used NMR spectroscopy to study the interactions of retinal with the visual protein rhodopsin. This work was under the direction of Edwin W. Abrahamsom and Gheorghe Matessecu. He joined the Department of Chemistry at UAB in 1982.Research Interests:
My research interests focus on the use and interpretation of spectroscopy, primarily nuclear magnetic resonance (NMR) and circular dichroism (CD). Recently, we have extended these spectroscopic approaches to include Fourier Transform Infrared (FT-IR) and Liquid Chromatography-Mass Spectroscopy (LC-MS). These spectroscopic approaches are used to solve problems of biological interest, especially as they apply to drug-protein interactions and drug design. Below is a summary of three main areas of research that are ongoing in my laboratory and personnel involved in each.
Conformationally Constrained Retinoids
Peptides that damage the cornea in the alkaine-injured eye
Synthetase: A New Target for Antibacterial Agents