Sadanandan E. Velu

Velu_home_picAssociate Professor of Chemistry, obtained his PhD degree in Organic Chemistry at the University of Madras (1993). He did his postdoctoral research at the University of Alabama and at Clemson University. Dr. Velu joined the Medicinal Chemistry division of the Center for Biophysical Sciences and Engineering of UAB in 1997 and worked as a Staff Scientist till 2004. He also held a joined appointment in the UAB Department of chemistry as a Research Faculty during 2002-2004. He joined the Chemistry department as an Assistant Professor in August of 2004. Dr. Velu got tenured and promoted to Associate Professor Rank in 2010.

Office:
CHEM-280

Phone: (205) 975 2478
Lab:     (205) 996 4194
Fax:      (205) 934 2543
Email: svelu@uab.edu

 

 

UAB Affiliations and Co-appointments

Associate Scientist, Comprehensive Cancer Center (CCC-UAB)
• Associate Scientist, Center for Clinical and Translational Science (CCTS-UAB)
• Faculty, Cystic Fibrosis Research Center (CFRC-UAB)
• Member, Center for Biophysical Sciences and Engineering (CBSE-UAB)
• Member, Center for Free Radical Biology(CFRB-UAB)
• Member, Lung Health Center (LHL-UAB)


Society Affiliations and Memberships

• American Association of Cancer Research (AACR)
• Society of Clinical and Translational Science (SCTS)
• American Chemical Society (ACS)
-- Division of Medicinal Chemistry
-- Division of Organic Chemistry
• American Heart Association (AHA)
--Council on Basic Cardiovascular Sciences
--Stroke Council


Selected Recent Publications

1.    Xu, S., Nguyen, T., Pomilio, I., Vitale, M. C. and Velu, S. E., Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione, Tetrahedron, 2014, 70, 5928-5933.

2.    Vayalil, P.K., Oh, J.-Y., Zhou, F., Diers, A.r., Smith, M.R., Golzarian, H., Oliver, P.G., Smith, R.A.J., Murphy, M.P., Velu, S. E. and Landar, A., A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms, PLOS ONE, IN PRESS, 2014.

3.    Shim, E-H., Livi, C. B., Rakheja, D., Tan, J., Benson, D., Parekh, V., Kho, E-Y., Ghosh, A. P., Kirkman, R., Velu, S. E., Dutta, S., Chenna, B., Rea, S. L., Mishur,, R. J., Li, Q., Johnson-Pais, T. L., Guo, L., Bae, S., Wei, S., Block, K. and Sudarshan, S., L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer, Cancer Discovery, Published On-Line, Published OnlineFirst September 2, 2014, doi: 10.1158/2159-8290.CD-13-0696.

4.    Nijampatnam, B., Nadkarni, D. H., Wu, H. and Velu, S. E., Antibacterial and Antibiofilm Activities of Makaluvamine Analogs, Microorganisms, 2014, 2, 128-139.

5.    Nadkarni, D. H., Murugesan, S. and Velu, S. E., Total synthesis of zyzzyanones A-D, Tetrahedron, 2013, 69, 4105-4113.

6.    Chen, D., Wang, W., Wang, M-H., Wang, H., Murugesan, S., Nadkarni, D. H., Velu, S. E. and Zhang, R.; The ZAK-MKK4-JNK-TGFβ Signaling Pathway Is a Molecular Target for Novel   Synthetic Iminoquinone Analog BA-TPQ in Breast Cancer Cells; Current Cancer Drug Targets, 2013, 13, 651-660.

7.    Nguyen, T., Nadkarni, D., Dutta, S., Xu, S., Kim, S., Murugesan, S. and Velu, S. E., Synthesis of Pyrroloquinones via a CAN Mediated Oxidative FreeRadical Reaction of 1,3-Dicarbonyl Compounds with Aminoquinones, Journal of Chemistry, 2013,1-12.

8.    Keeling, K. M., Wang, D., Dai, Y., Murugesan, S., Chenna, B., Clark, J., Belakhov, V., Kandasamy, J., Velu, S. E., Baasov, T. and Bedwell, D. M., Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression, PLOS ONE, 2013, 8, e60478.

9.    Jarboe, J.S., Dutta, S., Velu, S.E. and Willey, C.D., “Mini-Review: Bmx Kinase Inhibitors for Cancer Therapy”; Recent Patents on Anti-Cancer Drug Discovery, 2013, 8, 228-238.

10. Nag, S., Nadkarni, D. H., Qin, J-J., Voruganti, S. Nguyen, T., Xu, S., Wang, W., Wang, H., Velu, S.E., Zhang, R., “Anticancer Activity and Molecular Mechanisms of Action of Makaluvamines and Analogues”, Molecular and Cellular Pharmacology, 2012, 4, 69-81.

11.  Zhang, X., Xu, H., Zhang, X., Voruganti, S., Murugesan, S., Nadkarni, D.H., Velu, S.E., Wang, M-H., Wang, W., Zhang, R., “Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog”, Marine Drugs, 2012, 10, 1138-1155.

12.  McMichael, M., Nguyen, T., Saunders, T., Lee, P., Schormann, N., Chattopadhyay, D., Velu, S.E., “Structure Based Design of Inhibitors of Trypanosoma cruzi DHFR as Potential Therapeutic Agents for Chagas’ Disease”, Inquiro, 2012, 5, 54-59.

13.  Chen, T., Xu, Y., Guo, H., Liu, Y., Hu, P., Yang, X., Li, X., Ge, S., Velu, S.E., Nadkarni, D.H., Wang, W., Zhang, R., and Wang, H., Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action. PLoS One, 2011. 6(6): p. e20729.

14. Anderson, J.T., Zeng, M., Li, Q., Stapley, R., Moore, D.R., 2nd, Chenna, B., Fineberg, N., Zmijewski, J., Eltoum, I.E., Siegal, G.P., Gaggar, A., Barnes, S., Velu, S.E., Thannickal, V.J., Abraham, E., Patel, R.P., Lancaster, J.R., Jr., Chaplin, D.D., Dransfield, M.T., and Deshane, J.S., Elevated levels of NO are localized to distal airways in asthma. Free Radical Biology and Medicine, 2011, 50, 1679-88.

15. Li, H.; Ezell, S. J.; Wang, W.; Xu, H.; Rayburn, E. R.; Zhang, X.; Gurpinar, E.; Yang, X.; Sommers, C. I.; Velu, S. E.; Zhang, R.’ Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice, Biomedical Chromatography, 2011, 25, 628-634.

16.  Chenna, B.C.; King, J.R.; Shinkre, B.A.; Glover, A.L.; Lucius, A.L.; and Velu, S.E., Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors, European Journal of Medicinal Chemistry, 2010, 45, 3572-3761.

17.  Ezell, S. J.; Li, H.; Xu, H.; Zhang, X.; Gurpinar, E.; Zhang, X.; Rayburn, E. R.;Sommers, C. I.; Yang, X; Velu, S. E.; Wang, W. and Zhang, R., Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent, Marine Drugs, 2010, 8, 2129-2141.

18.  Schormann, N.; Velu, S. E.; Murugesan, S.; Senkovich, O.; Walker, K.; Chenna, B.; Shinkre, B.; Desai, A. and Chattopadhyay, D., Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase, Bioorganic and Medicinal Chemistry, 2010, 18, 4056-4066

19.  Wang, W.; Rayburn, E. R.; Velu, S. E.; Chen, D.; Nadkarni, D. H.; Murugesan, S.; Chen, D. and Zhang, R., A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action, Breast Cancer Research and Treatment, 2010, 123, 321-331.

20.  Wang, F.; Ezell, S. J.;Zhang, Y.; Wang, W.; Rayburn, E. R.;Nadkarni, D. H.;Murugesan, S.; Velu, S. E. and Zhang, R., FBA-TPQ, a Novel Marine-Derived Compound as Experimental Therapy for Prostate Cancer, Investigational New Drugs, 2010, 28, 234-241.

21. Murugesan, S.; Nadkarni, D. H.; Velu, S. E., A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids, Tetrahedron Letters, 2009, 50, 3074-3076.

22.  Wang, W.; Velu, S. E., Nadkarni, D. H.; Murugesan, S.; Rayburn, E. R. and Zhang, R., In Vitro and In vivo Anti-cancer Activity of Novel Synthetic Makaluvamine Analogues, Clinical Cancer Research, 2009, 15, 3511-3518.

23.  Nadkarni, D. H.; Wang, F.; Wang, W.; Rayburn, E. R.; Ezell, S. J.; Murugesan, S.; Velu, S. E. and Zhang, R., Synthesis and In Vitro Anti-cancer Activity of Novel 1, 3, 4, 8-Tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one Alkaloid Analogues, Medicinal Chemistry, 2009, 5, 227-236.       

24. Kang, S.; Mou, L.; Velu, S. E.; Brouillette, W. J.; Prevelige Jr., P. E., Synthesis of Biotin Tagged Chemical Cross-linkers and Their Applications for Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2009, 23, 1719-1726.

25. Patel, S. P.; Nadkarni, D. H.; Murugesan, S.; King, J. R. and Velu, S. E., Azide mediated detosylation of N-tosylpyrroloiminoquinones and N-tosylindole-4,7-quinones, Synlett, 2008, 2864-2868.

26. Schormann, N.; Senkovich, O.; Walker, K.; Wright, D. L.; Anderson, A. C.; Rosowsky, A.; Ananthan, S.; Shinkre, B. A.; Velu, S. E. and Chattopadhyay, D., Structure-based approach to pharmacophore identification, in silico screening and 3D-QSAR studies for inhibitors of Trypanosoma cruzi DHFR function, Proteins: Structure, Function, and Bioinformatics, 2008, 73, 889-901.

27. Shinkre, B. A.; Raisch, K. P.; Fan, L.; Velu, S. E., Synthesis and Antiproliferative Activity of Benzyl and Phenethyl Analogs of Makaluvamines, Bioorganic and Medicinal Chemistry, 2008, 16, 2541-2549.

28. Chenna, B., Shinkre, B, A., King, J. R., Lucius, A. L., Narayana, S. V. L. and Velu, S. E., Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A, Bioorganic and Medicinal Chemistry Letters, 2008, 18, 380-385.

29. Shinkre, B. A.; Velu, S. E., Total synthesis of Secobatzelline B., Synthetic Communications, 2007, 37, (14), 2399-2409.

30.  Velu, S. E.; Mou, L.; Luan, C. H.; Yang, Z. W.; DeLucas, L. J.; Brouillette, C. G.; Brouillette, W. J., Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry, 2007, 50, (11), 2612-21.

31.  Shinkre, B. A.; Raisch, K. P.; Fan, L.; Velu, S. E., Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity, Bioorganic and Medicinal Chemistry Letters, 2007, 17, (10), 2890-3.