Publications

Complete List of Publications


1.    Xu, S., Nguyen, T., Pomilio, I., Vitale, M. C. and Velu, S. E., Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione, Tetrahedron, 2014, 70, 5928-5933.

2.    Vayalil, P.K., Oh, J.-Y., Zhou, F., Diers, A.R., Smith, M.R., Golzarian, H., Oliver, P.G., Smith, R.A.J., Murphy, M.P., Velu, S. E. and Landar, A., A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms, PLOS ONE, IN PRESS, 2014.

3.    Shim, E-H., Livi, C. B., Rakheja, D., Tan, J., Benson, D., Parekh, V., Kho, E-Y., Ghosh, A. P., Kirkman, R., Velu, S. E., Dutta, S., Chenna, B., Rea, S. L., Mishur,, R. J., Li, Q., Johnson-Pais, T. L., Guo, L., Bae, S., Wei, S., Block, K. and Sudarshan, S., L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer, Cancer Discovery, Published On-Line, Published OnlineFirst September 2, 2014, doi: 10.1158/2159-8290.CD-13-0696.

4.    Nijampatnam, B., Nadkarni, D. H., Wu, H. and Velu, S. E., Antibacterial and Antibiofilm Activities of Makaluvamine Analogs, Microorganisms, 2014, 2, 128-139.

5.    Nadkarni, D. H., Murugesan, S. and Velu, S. E., Total synthesis of zyzzyanones A-D, Tetrahedron, 2013, 69, 4105-4113.

6.    Chen, D., Wang, W., Wang, M-H., Wang, H., Murugesan, S., Nadkarni, D. H., Velu, S. E. and Zhang, R.; The ZAK-MKK4-JNK-TGFβ Signaling Pathway Is a Molecular Target for Novel   Synthetic Iminoquinone Analog BA-TPQ in Breast Cancer Cells; Current Cancer Drug Targets, 2013, 13, 651-660.

7.    Nguyen, T., Nadkarni, D., Dutta, S., Xu, S., Kim, S., Murugesan, S. and Velu, S. E., Synthesis of Pyrroloquinones via a CAN Mediated Oxidative FreeRadical Reaction of 1,3-Dicarbonyl Compounds with Aminoquinones, Journal of Chemistry, 2013,1-12.

8.    Keeling, K. M., Wang, D., Dai, Y., Murugesan, S., Chenna, B., Clark, J., Belakhov, V., Kandasamy, J., Velu, S. E., Baasov, T. and Bedwell, D. M., Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression, PLOS ONE, 2013, 8, e60478.

9.    Jarboe, J.S., Dutta, S., Velu, S.E. and Willey, C.D., “Mini-Review: Bmx Kinase Inhibitors for Cancer Therapy”; Recent Patents on Anti-Cancer Drug Discovery, 2013, 8, 228-238.

10. Nag, S., Nadkarni, D. H., Qin, J-J., Voruganti, S. Nguyen, T., Xu, S., Wang, W., Wang, H., Velu, S.E., Zhang, R., “Anticancer Activity and Molecular Mechanisms of Action of Makaluvamines and Analogues”, Molecular and Cellular Pharmacology, 2012, 4, 69-81.

11.  Zhang, X., Xu, H., Zhang, X., Voruganti, S., Murugesan, S., Nadkarni, D.H., Velu, S.E., Wang, M-H., Wang, W., Zhang, R., “Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog”, Marine Drugs, 2012, 10, 1138-1155.

12.  McMichael, M., Nguyen, T., Saunders, T., Lee, P., Schormann, N., Chattopadhyay, D., Velu, S.E., “Structure Based Design of Inhibitors of Trypanosoma cruzi DHFR as Potential Therapeutic Agents for Chagas’ Disease”, Inquiro, 2012, 5, 54-59.

13.  Chen, T., Xu, Y., Guo, H., Liu, Y., Hu, P., Yang, X., Li, X., Ge, S., Velu, S.E., Nadkarni, D.H., Wang, W., Zhang, R., and Wang, H., Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action. PLoS One, 2011. 6(6): p. e20729.

14. Anderson, J.T., Zeng, M., Li, Q., Stapley, R., Moore, D.R., 2nd, Chenna, B., Fineberg, N., Zmijewski, J., Eltoum, I.E., Siegal, G.P., Gaggar, A., Barnes, S., Velu, S.E., Thannickal, V.J., Abraham, E., Patel, R.P., Lancaster, J.R., Jr., Chaplin, D.D., Dransfield, M.T., and Deshane, J.S., Elevated levels of NO are localized to distal airways in asthma. Free Radical Biology and Medicine, 2011, 50, 1679-88.

15. Li, H.; Ezell, S. J.; Wang, W.; Xu, H.; Rayburn, E. R.; Zhang, X.; Gurpinar, E.; Yang, X.; Sommers, C. I.; Velu, S. E.; Zhang, R.’ Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice, Biomedical Chromatography, 2011, 25, 628-634.

16.  Chenna, B.C.; King, J.R.; Shinkre, B.A.; Glover, A.L.; Lucius, A.L.; and Velu, S.E., Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors, European Journal of Medicinal Chemistry, 2010, 45, 3572-3761.

17.  Ezell, S. J.; Li, H.; Xu, H.; Zhang, X.; Gurpinar, E.; Zhang, X.; Rayburn, E. R.;Sommers, C. I.; Yang, X; Velu, S. E.; Wang, W. and Zhang, R., Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent, Marine Drugs, 2010, 8, 2129-2141.

18.  Schormann, N.; Velu, S. E.; Murugesan, S.; Senkovich, O.; Walker, K.; Chenna, B.; Shinkre, B.; Desai, A. and Chattopadhyay, D., Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase, Bioorganic and Medicinal Chemistry, 2010, 18, 4056-4066

19.  Wang, W.; Rayburn, E. R.; Velu, S. E.; Chen, D.; Nadkarni, D. H.; Murugesan, S.; Chen, D. and Zhang, R., A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action, Breast Cancer Research and Treatment, 2010, 123, 321-331.

20.  Wang, F.; Ezell, S. J.;Zhang, Y.; Wang, W.; Rayburn, E. R.;Nadkarni, D. H.;Murugesan, S.; Velu, S. E. and Zhang, R., FBA-TPQ, a Novel Marine-Derived Compound as Experimental Therapy for Prostate Cancer, Investigational New Drugs, 2010, 28, 234-241.

21. Murugesan, S.; Nadkarni, D. H.; Velu, S. E., A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids, Tetrahedron Letters, 2009, 50, 3074-3076.

22.  Wang, W.; Velu, S. E., Nadkarni, D. H.; Murugesan, S.; Rayburn, E. R. and Zhang, R., In Vitro and In vivo Anti-cancer Activity of Novel Synthetic Makaluvamine Analogues, Clinical Cancer Research, 2009, 15, 3511-3518.

23.  Nadkarni, D. H.; Wang, F.; Wang, W.; Rayburn, E. R.; Ezell, S. J.; Murugesan, S.; Velu, S. E. and Zhang, R., Synthesis and In Vitro Anti-cancer Activity of Novel 1, 3, 4, 8-Tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one Alkaloid Analogues, Medicinal Chemistry, 2009, 5, 227-236.       

24. Kang, S.; Mou, L.; Velu, S. E.; Brouillette, W. J.; Prevelige Jr., P. E., Synthesis of Biotin Tagged Chemical Cross-linkers and Their Applications for Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2009, 23, 1719-1726.

25.  Lee, Y. J.; King, J. R.; Chenna, B.; Owens Jr., S. B.; Freeman, J. L.; Gray, G. M. and Velu, S. E., Synthesis and the crystal structure of (E)-2-(7-(3-(thiophen-2-yl)acrylamido)-2,3-dihydro-5-oxobenzo[e][1,4]oxazepin-1(5H)-yl)ethyl acetate, Journal of Chemical Crystallography, 2009, 39, 902-907.

26. Patel, S. P.; Nadkarni, D. H.; Murugesan, S.; King, J. R. and Velu, S. E., Azide mediated detosylation of N-tosylpyrroloiminoquinones and N-tosylindole-4,7-quinones, Synlett, 2008, 2864-2868.

27. Schormann, N.; Senkovich, O.; Walker, K.; Wright, D. L.; Anderson, A. C.; Rosowsky, A.; Ananthan, S.; Shinkre, B. A.; Velu, S. E. and Chattopadhyay, D., Structure-based approach to pharmacophore identification, in silico screening and 3D-QSAR studies for inhibitors of Trypanosoma cruzi DHFR function, Proteins: Structure, Function, and Bioinformatics, 2008, 73, 889-901.

28. Chenna, B.; Shinkre, B. A.; Patel, S.; Owens Jr., S. B.; Gray. G. M. and Velu, S. E., Synthesis, separation and crystal structures of E and Z isomers of 3 - (2, 5- dimethoxyphenyl) - 2 - (4 - methoxyphenyl) acrylic acid., Journal of Chemical Crystallography, 2008, 38, 189-194.

29. Shinkre, B. A.; Raisch, K. P.; Fan, L.; Velu, S. E., Synthesis and Antiproliferative Activity of Benzyl and Phenethyl Analogs of Makaluvamines, Bioorganic and Medicinal Chemistry, 2008, 16, 2541-2549.

30. Chenna, B., Shinkre, B, A., King, J. R., Lucius, A. L., Narayana, S. V. L. and Velu, S. E., Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A, Bioorganic and Medicinal Chemistry Letters, 2008, 18, 380-385.

31.  Shinkre, B. A.; Nadkarni, D. H.; Owens Jr., S. B.; Gray, G. M. and Velu, S. E., Synthesis of E isomer and crystal structures of E & Z isomers of 3-(2, 5 - dimethoxyphenyl) - 2 - (4 - methoxyphenyl) acrylonitrile., Journal of Chemical Crystallography, 2008, 38, 205-209.

32. Shinkre, B. A.; Velu, S. E., Total synthesis of Secobatzelline B., Synthetic Communications, 2007, 37, (14), 2399-2409.

33.  Velu, S. E.; Mou, L.; Luan, C. H.; Yang, Z. W.; DeLucas, L. J.; Brouillette, C. G.; Brouillette, W. J., Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry, 2007, 50, (11), 2612-21.

34.  Shinkre, B. A.; Raisch, K. P.; Fan, L.; Velu, S. E., Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity, Bioorganic and Medicinal Chemistry Letters, 2007, 17, (10), 2890-3.

35.  Velu, S. E.; Luan, C. H.; Delucas, L. J.; Brouillette, C. G.; Brouillette, W. J., Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry, 2005, 7, (6), 898-904.

36.  Velu, S. E.; Cristofoli, W. A.; Garcia, G. J.; Brouillette, C. G.; Pierson, M. C.; Luan, C. H.; DeLucas, L. J.; Brouillette, W. J., Tethered dimers as NAD synthetase inhibitors with antibacterial activity, Journal of Medicinal Chemistry, 2003, 46, (15), 3371-81.

37.  Brouillette, W. J.; Bajpai, S. N.; Ali, S. M.; Velu, S. E.; Atigadda, V. R.; Lommer, B. S.; Finley, J. B.; Luo, M.; Air, G. M., Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents, Bioorganic and Medicinal Chemistry 2003, 11, (13), 2739-49.

38. Dieter, R. K.; Lu, K.; Velu, S. E., Conjugate addition reactions of alpha-aminoalkylcuprates with -alkenyl-, -alkynyl-, -allenyl-, and -dienyl carboxylic acid derivatives, nitriles, and sulfoxides, Journal of Organic Chemistry, 2000, 65, (25), 8715-24.

39.  Dieter, R. K.; Velu, S. E., (-Aminoalkyl)cuprates Prepared from Soluble Copper(I) Salts: Conjugate Additions to -Unsaturated Carboxylic Acid Derivatives, Journal of Organic Chemistry 1997, 62, (12), 3798-3799.

40.  Dieter, R. K.; Velu, S. E.; Nice, L. E., Regioselective control in the reactions of a-aminoalkylcuprates with allylic substrates. Synlett, 1997, (9), 1114-1116.

41.  Dieter, R. K.; Nice, L. E.; Velu, S. E., Oxidation of ,-enones and alkenes with oxone and sodium halides: a convenient laboratory preparation of chlorine and bromine. Tetrahedron Letters, 1996, 37, (14), 2377-80.

42.  Jackson, Y. A.; Billimoria, A. D.; Velu, S., E.; Cava, M. P., Regioselective Amination of Indole-4,7-quinones, Journal of Organic Chemistry, 1995, 60, (11), 3543-5.

43.  Velu, S., E.; Pillai, S. K.; Lakshmikantham, M. V.; Billimoria, A. D.; Culpepper, J. S.; Cava, M. P., Efficient Syntheses of the Marine Alkaloids Makaluvamine D and Discorhabdin C: The 4,6,7-Trimethoxyindole Approach, Journal of Organic Chemistry, 1995, 60, (6), 1800-5.

44.  Sivaraman, J. Subramanian, K., Velmurugan, D., Subramanian, E., and Velu, S. E., 2- [2- (4-methoxyphenyl) -1- (phenylsulfonyl)vinyl] -3- phenylthioindole, Acta Cryst., C50, 789 791 (1994).

45. Sivaraman, J. Subramanian, K., Velmurugan, D., Subramanian, E., and Velu, S. E., “2-(3,4-methylenedioxyphenyl) -1- (phenylsulfonyl)vinyl] -3- phenylthioindole, Acta Cryst., C50, 787 789 (1994).

46.  Parakka, J.P.; Velu, S., E. and Cava, M. P., A Novel o-Quinodimethane Tandem Diels - Alder Reaction., Journal of Organic Chemistry, 1994, 59, 4308 - 4310.

47. Sivaraman, J. Subramanian, K., Velmurugan, D., Subramanian, E., and Velu, S. E., 2-[1-Phenylsulfonyl -2- (3,4,5-trimethoxyphenyl) vinyl] -3- phenylthioindole, Acta Cryst., C50, 784 787 (1994).

48. Velu, S. E., Vedachalam, M. V. and Srinivasan, P. C., 2-Alkyl indoles via Wittig Olefination of Indole-2-aldehyde, Indian Journal of Chemistry, 32B, 481 (1993).

49. Velu, S. E. and Cava, M. P., Total Synthesis of Damirone A and Damirone B, Tetrahedron Letters, 34, 2405 (1993).

50. Velu, S. E. and Srinivasan, P. C., Synthesis of 2-Alkyl indoles via Sulfones, Synthesis, 648 650 (1992).


 

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