Publications

Complete List of Publications

1.  Nadkarni, D. H., Murugesan, S. and Velu, S. E., Total synthesis of zyzzyanones A-D, Tetrahedron, 2013, 69, 4105-4113.

2.  Chen, D., Wang, W., Wang, M-H., Wang, H., Murugesan, S., Nadkarni, D. H., Velu, S. E. and Zhang, R.; The ZAK-MKK4-JNK-TGFβ Signaling Pathway Is a Molecular Target for Novel   Synthetic Iminoquinone Analog BA-TPQ in Breast Cancer Cells; Current Cancer Drug Targets, 2013, 13, 651-660.

3.   Nguyen, T., Nadkarni, D., Dutta, S., Xu, S., Kim, S., Murugesan, S. and Velu, S. E., Synthesis of Pyrroloquinones via a CAN Mediated Oxidative FreeRadical Reaction of 1,3-Dicarbonyl Compounds with Aminoquinones, Journal of Chemistry, 2013, IN PRESS.

4.  Keeling, K. M., Wang, D., Dai, Y., Murugesan, S., Chenna, B., Clark, J., Belakhov, V., Kandasamy, J., Velu, S. E., Baasov, T. and Bedwell, D. M., Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression, PLOS ONE, 2013, 8, e60478.

5.  Jarboe, J.S., Dutta, S., Velu, S.E. and Willey, C.D., “Mini-Review: Bmx Kinase Inhibitors for Cancer Therapy”; Recent Patents on Anti-Cancer Drug Discovery, 2013, 8, 228-238.

6.  Nag, S., Nadkarni, D. H., Qin, J-J., Voruganti, S. Nguyen, T., Xu, S., Wang, W., Wang, H., Velu, S.E., Zhang, R., “Anticancer Activity and Molecular Mechanisms of Action of Makaluvamines and Analogues”, Molecular and Cellular Pharmacology, 2012, 4, 69-81.

7.   Zhang, X., Xu, H., Zhang, X., Voruganti, S., Murugesan, S., Nadkarni, D.H., Velu, S.E., Wang, M-H., Wang, W., Zhang, R., “Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog”, Marine Drugs, 2012, 10, 1138-1155.

8.   McMichael, M., Nguyen, T., Saunders, T., Lee, P., Schormann, N., Chattopadhyay, D., Velu, S.E., “Structure Based Design of Inhibitors of Trypanosoma cruzi DHFR as Potential Therapeutic Agents for Chagas’ Disease”, Inquiro, 2012, 5, 54-59.

9.   Chen, T., Xu, Y., Guo, H., Liu, Y., Hu, P., Yang, X., Li, X., Ge, S., Velu, S.E., Nadkarni, D.H., Wang, W., Zhang, R., and Wang, H., Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action. PLoS One, 2011. 6(6): p. e20729.

10.  Anderson, J.T., Zeng, M., Li, Q., Stapley, R., Moore, D.R., 2nd, Chenna, B., Fineberg, N., Zmijewski, J., Eltoum, I.E., Siegal, G.P., Gaggar, A., Barnes, S., Velu, S.E., Thannickal, V.J., Abraham, E., Patel, R.P., Lancaster, J.R., Jr., Chaplin, D.D., Dransfield, M.T., and Deshane, J.S., Elevated levels of NO are localized to distal airways in asthma. Free Radical Biology and Medicine, 2011, 50, 1679-88.

11.  Li, H.; Ezell, S. J.; Wang, W.; Xu, H.; Rayburn, E. R.; Zhang, X.; Gurpinar, E.; Yang, X.; Sommers, C. I.; Velu, S. E.; Zhang, R.’ Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice, Biomedical Chromatography, 2011, 25, 628-634.

12.  Chenna, B.C.; King, J.R.; Shinkre, B.A.; Glover, A.L.; Lucius, A.L.; and Velu, S.E., Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors, European Journal of Medicinal Chemistry, 2010, 45, 3572-3761.

13.  Ezell, S. J.; Li, H.; Xu, H.; Zhang, X.; Gurpinar, E.; Zhang, X.; Rayburn, E. R.;Sommers, C. I.; Yang, X; Velu, S. E.; Wang, W. and Zhang, R., Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent, Marine Drugs, 2010, 8, 2129-2141.

14.  Schormann, N.; Velu, S. E.; Murugesan, S.; Senkovich, O.; Walker, K.; Chenna, B.; Shinkre, B.; Desai, A. and Chattopadhyay, D., Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase, Bioorganic and Medicinal Chemistry, 2010, 18, 4056-4066

15.  Wang, W.; Rayburn, E. R.; Velu, S. E.; Chen, D.; Nadkarni, D. H.; Murugesan, S.; Chen, D. and Zhang, R., A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action, Breast Cancer Research and Treatment, 2010, 123, 321-331.

16.  Wang, F.; Ezell, S. J.;Zhang, Y.; Wang, W.; Rayburn, E. R.;Nadkarni, D. H.;Murugesan, S.; Velu, S. E. and Zhang, R., FBA-TPQ, a Novel Marine-Derived Compound as Experimental Therapy for Prostate Cancer, Investigational New Drugs, 2010, 28, 234-241.

17.  Murugesan, S.; Nadkarni, D. H.; Velu, S. E., A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids, Tetrahedron Letters, 2009, 50, 3074-3076.

18.  Wang, W.; Velu, S. E., Nadkarni, D. H.; Murugesan, S.; Rayburn, E. R. and Zhang, R., In Vitro and In vivo Anti-cancer Activity of Novel Synthetic Makaluvamine Analogues, Clinical Cancer Research, 2009, 15, 3511-3518.

19.  Nadkarni, D. H.; Wang, F.; Wang, W.; Rayburn, E. R.; Ezell, S. J.; Murugesan, S.; Velu, S. E. and Zhang, R., Synthesis and In Vitro Anti-cancer Activity of Novel 1, 3, 4, 8-Tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one Alkaloid Analogues, Medicinal Chemistry, 2009, 5, 227-236.  

20.  Kang, S.; Mou, L.; Velu, S. E.; Brouillette, W. J.; Prevelige Jr., P. E., Synthesis of Biotin Tagged Chemical Cross-linkers and Their Applications for Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2009, 23, 1719-1726.

21.  Lee, Y. J.; King, J. R.; Chenna, B.; Owens Jr., S. B.; Freeman, J. L.; Gray, G. M. and Velu, S. E., Synthesis and the crystal structure of (E)-2-(7-(3-(thiophen-2-yl)acrylamido)-2,3-dihydro-5-oxobenzo[e][1,4]oxazepin-1(5H)-yl)ethyl acetate, Journal of Chemical Crystallography, 2009, 39, 902-907.

22.  Patel, S. P.; Nadkarni, D. H.; Murugesan, S.; King, J. R. and Velu, S. E., Azide mediated detosylation of N-tosylpyrroloiminoquinones and N-tosylindole-4,7-quinones, Synlett, 2008, 2864-2868.

23.  Schormann, N.; Senkovich, O.; Walker, K.; Wright, D. L.; Anderson, A. C.; Rosowsky, A.; Ananthan, S.; Shinkre, B. A.; Velu, S. E. and Chattopadhyay, D., Structure-based approach to pharmacophore identification, in silico screening and 3D-QSAR studies for inhibitors of Trypanosoma cruzi DHFR function, Proteins: Structure, Function, and Bioinformatics, 2008, 73, 889-901.

24.  Chenna, B.; Shinkre, B. A.; Patel, S.; Owens Jr., S. B.; Gray. G. M. and Velu, S. E., Synthesis, separation and crystal structures of E and Z isomers of 3 - (2, 5- dimethoxyphenyl) - 2 - (4 - methoxyphenyl) acrylic acid., Journal of Chemical Crystallography, 2008, 38, 189-194.

25. Shinkre, B. A.; Raisch, K. P.; Fan, L.; Velu, S. E., Synthesis and Antiproliferative Activity of Benzyl and Phenethyl Analogs of Makaluvamines, Bioorganic and Medicinal Chemistry, 2008, 16, 2541-2549.

26. Chenna, B., Shinkre, B, A., King, J. R., Lucius, A. L., Narayana, S. V. L. and Velu, S. E., Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A, Bioorganic and Medicinal Chemistry Letters, 2008, 18, 380-385.

27.  Shinkre, B. A.; Nadkarni, D. H.; Owens Jr., S. B.; Gray, G. M. and Velu, S. E., Synthesis of E isomer and crystal structures of E & Z isomers of 3-(2, 5 - dimethoxyphenyl) - 2 - (4 - methoxyphenyl) acrylonitrile., Journal of Chemical Crystallography, 2008, 38, 205-209.

28.  Shinkre, B. A.; Velu, S. E., Total synthesis of Secobatzelline B., Synthetic Communications, 2007, 37, (14), 2399-2409.

29.  Velu, S. E.; Mou, L.; Luan, C. H.; Yang, Z. W.; DeLucas, L. J.; Brouillette, C. G.; Brouillette, W. J., Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry, 2007, 50, (11), 2612-21.

30.  Shinkre, B. A.; Raisch, K. P.; Fan, L.; Velu, S. E., Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity, Bioorganic and Medicinal Chemistry Letters, 2007, 17, (10), 2890-3.

31.  Velu, S. E.; Luan, C. H.; Delucas, L. J.; Brouillette, C. G.; Brouillette, W. J., Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry, 2005, 7, (6), 898-904.

32.  Velu, S. E.; Cristofoli, W. A.; Garcia, G. J.; Brouillette, C. G.; Pierson, M. C.; Luan, C. H.; DeLucas, L. J.; Brouillette, W. J., Tethered dimers as NAD synthetase inhibitors with antibacterial activity, Journal of Medicinal Chemistry, 2003, 46, (15), 3371-81.

33.  Brouillette, W. J.; Bajpai, S. N.; Ali, S. M.; Velu, S. E.; Atigadda, V. R.; Lommer, B. S.; Finley, J. B.; Luo, M.; Air, G. M., Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents, Bioorganic and Medicinal Chemistry 2003, 11, (13), 2739-49.

34. Dieter, R. K.; Lu, K.; Velu, S. E., Conjugate addition reactions of alpha-aminoalkylcuprates with a,b-alkenyl-, a,b-alkynyl-, a,b-b,g-allenyl-, and a,b-g,d-dienyl carboxylic acid derivatives, nitriles, and sulfoxides, Journal of Organic Chemistry, 2000, 65, (25), 8715-24.

35.  Dieter, R. K.; Velu, S. E,, (a-Aminoalkyl)cuprates Prepared from Soluble Copper(I) Salts: Conjugate Additions to a,b-Unsaturated Carboxylic Acid Derivatives, Journal of Organic Chemistry 1997, 62, (12), 3798-3799.

36.  Dieter, R. K.; Velu, S. E.; Nice, L. E., Regioselective control in the reactions of a-aminoalkylcuprates with allylic substrates. Synlett, 1997, (9), 1114-1116.

37.  Dieter, R. K.; Nice, L. E.; Velu, S. E., Oxidation of a,b-enones and alkenes with oxone and sodium halides: a convenient laboratory preparation of chlorine and bromine. Tetrahedron Letters, 1996, 37, (14), 2377-80.

38.  Jackson, Y. A.; Billimoria, A. D.; Velu, S., E.; Cava, M. P., Regioselective Amination of Indole-4,7-quinones, Journal of Organic Chemistry, 1995, 60, (11), 3543-5.

39.  Velu, S., E.; Pillai, S. K.; Lakshmikantham, M. V.; Billimoria, A. D.; Culpepper, J. S.; Cava, M. P., Efficient Syntheses of the Marine Alkaloids Makaluvamine D and Discorhabdin C: The 4,6,7-Trimethoxyindole Approach, Journal of Organic Chemistry, 1995, 60, (6), 1800-5.

40.  Sivaraman, J. Subramanian, K., Velmurugan, D., Subramanian, E., and Velu, S. E., 2- [2- (4-methoxyphenyl) -1- (phenylsulfonyl)vinyl] -3- phenylthioindole, Acta Cryst., C50, 789 791 (1994).

41.  Sivaraman, J. Subramanian, K., Velmurugan, D., Subramanian, E., and Velu, S. E., “2-(3,4-methylenedioxyphenyl) -1- (phenylsulfonyl)vinyl] -3- phenylthioindole, Acta Cryst., C50, 787 789 (1994).

42.  Parakka, J.P.; Velu, S., E. and Cava, M. P., A Novel o-Quinodimethane Tandem Diels - Alder Reaction., Journal of Organic Chemistry, 1994, 59, 4308 - 4310.

43.  Sivaraman, J. Subramanian, K., Velmurugan, D., Subramanian, E., and Velu, S. E., 2-[1-Phenylsulfonyl -2- (3,4,5-trimethoxyphenyl) vinyl] -3- phenylthioindole, Acta Cryst., C50, 784 787 (1994).

44.  Velu, S. E., Vedachalam, M. V. and Srinivasan, P. C., 2-Alkyl indoles via Wittig Olefination of Indole-2-aldehyde, Indian Journal of Chemistry, 32B, 481 (1993).

45.  Velu, S. E. and Cava, M. P., Total Synthesis of Damirone A and Damirone B, Tetrahedron Letters, 34, 2405 (1993).

46.  Velu, S. E. and Srinivasan, P. C., Synthesis of 2-Alkyl indoles via Sulfones, Synthesis, 648 650 (1992).

 



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