Publications:

2000

•  Buchsbaum DJ , Khazaeli MB, LoBuglio AF , Meredith RF, Axworthy DB, Theodore L, Schultz J, Lin Y-K, Zuo Y, Sanderson J, Zinn KR : Biodistribution and imaging of pretargeted 125 I-CC49sFv 4 /SA fusion protein and 111 In-DOTA-biotin in an intraperitoneal tumor model. Cancer Biother Radiopharm, 15:395, 2000.

•  Krasnykh VN , Dmitriev I , Navarro JG, Belousova N, Kashentseva E, Xiang J, Douglas JT, Curiel DT: Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res 60:6784-6787, 2000.

•  Rogers BE, Zinn KR , Buchsbaum DJ : Gene transfer strategies for improving radiolabeled peptide imaging and therapy. Q J Nucl Med 44:208-223, 2000.

•  Zinn KR , Buchsbaum DJ , Chaudhuri TR, Mountz JM, Grizzle WE , Rogers BE: Noninvasive monitoring of gene transfer using a reporter receptor imaged with a high affinity peptide radiolabeled with 99mTc or 188Re. J Nucl Med 41:887-895, 2000.

2001

•  Barker SD, Casado E, Gomez-Navarro J, Xiang J, Arafat W, Mahasreshti P, Pustilnik TB, Hemminki A , Siegal GP, Alvarez RD , Curiel DT: An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascites. Gyn Onc 82:57-63, 2001.

•  Beenken SW , Grizzle WE , Crowe DR, Conner MG, Weiss HL, Sellers MT, Krontiras H , Urist MM, Bland KI: Molecular biomarkers for breast cancer prognosis: Co-expression of c-erbB-2 in p53. Annals of Surgery 233:630-638, 2001.

•  Casado E, Gomez-Navarro J, Yamamoto M, Adachi Y, Coolidge CJ, Arafat WO, Barker S, Wang MH, Mahasreshi PJ, Hemminki A , Gonzalez-Baron M, Barnes MN, Siegal GP, Alvarez RD, Curiel DT: Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications. Clin Cancer Res 7:2496-2504, 2001.

•  Casado E, Nettelbeck DM, Gomez-Navarro J, Hemminki A , Gonzalez-Baron M, Siegal GP, Barnes MN , Alvarez RD , Curiel DT: Transcriptional targeting for ovarian cancer gene therapy: A review. Gynecol Oncol 82:229-237, 2001.

•  Chaudhuri TR, Mountz JM, Rogers BE, Partridge EE, Zinn KR : Light-based imaging of green fluorescent protein-positive ovarian cancer xenografts during therapy. Gyn Oncol 82:581-589, 2001.

•  Hemminki A , Belousova N, Zinn KR , Liu B, Wang M, Chaudhuri TR, Rogers BE, Buchsbaum DJ , Siegal GP, Barnes MN , Gomez-Navarro J, Curiel DT, Alvarez RD : An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression. Mol Ther 4:223-231, 2001.

•  Hemminki A , Dmitriev I , Liu B, Desmond RA, Alemany R, Curiel DT: Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule. Cancer Res 61:6377-6381, 2001.

•  Ichikawa K, Liu W, Wang Z, Liu D, Koopman WJ, Kimberly RP, Zhou T : Tumoricidal activity of a novel anti-human DR5 monoclonal antibody. Nature Med 7:954-960, 2001.

•  Mahasreshti PJ, Navarro JG, Kataram M, Wang MH, Carey DE, Siegal GP, Barnes MN, Nettelbeck DM, Alvarez RD, Hemminki A , Curiel DT: Adenovirus-mediated soluble FLT-1 gene therapy for ovarian carcinoma. Clin Cancer Res 7:2057-2066, 2001.

•  Morrow M, Krontiras H : Who should not receive chemotherapy? Data from American databases and trials. J Natl Cancer Inst (Monographs) 30:109-113, 2001.

•  Zinn KR , Chaudhuri TR, Buchsbaum DJ , Mountz JM, Rogers BE: Detection and measurement of in vitro gene transfer by gamma camera imaging. Gene Therapy 8:291-299, 2001.

•  Zinn KR , Chaudhuri TR, Buchsbaum DJ, Mountz JM, Rogers BE: Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging. Nucl Med Biol 28:135-144, 2001.

2002

•  Arafat WO, Gomez-Navarro J, Buchsbaum DJ , Xiang J, Wang M, Casado E, Barker SD, Mahasreshti PJ, Haisma HJ, Barnes MN , Siegal GP, Alvarez RD , Hemminki A , Nettelback DM, Curiel DT: Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv. Gene Therapy 9:256-262, 2002.

•  Barnes MN , Coolidge CJ, Hemminki A , Alvarez RD , Curiel DT: Conditionally replicative adenoviruses for ovarian cancer therapy. Mol Cancer Ther 1:435-439, 2002.

•  Bauerschmitz GJ, Lam JT, Kanerva A, Suzuki K, Nettelbeck DM, Dmitriev I , Krasnykh VN , Mikheeva GV, Barnes MN , Alvarez RD , Dall P, Alemany R, Curiel DT, Hemminki A : Treatment of ovarian cancer with a tropism modified oncolytic adenovirus. Cancer Res 62:1266-1270, 2002.

•  Chaudhuri TR, Cao Z, Della Manna DL, Rodriguez-Burford C , Partridge EE, Zinn KR : A sensitive method for treatment monitoring of microscopic ovarian cancer in live mice. Mol Ther 5:S115, 2002.

•  Chaudhuri TR, Cao Z, Partridge EE, Zinn KR : A comparative analyses of light-based and gamma-camera imaging to detect non-palpable ovarian cancer lesion in nude mice. Mol Ther 5:S270, 2002.

•  Chaudhuri TR, Cao Z, Partridge EE, Zinn KR : A comparative analysis of optical and gamma camera imaging for non-invasive detection of ovarian cancer. Eur J Nuc Med Mol Imaging 29:S229, 2002.

•  Chaudhuri TR, Cao Z, Rodriquez-Burford C, LoBuglio AF , Zinn KR : A non-invasive approach for monitoring breast tumor cells during therapeutic intervention. Cancer Biother Radiopharm 17:205-212, 2002.

•  Chaudhuri TR, Krasnykh VN , Cao Z, Zinn KR : Dualistic genetic reporter system for early diagnosis and monitoring of ovarian cancer. Mol Ther 5:S207, 2002.

•  Dmitriev IP , Kashentseva EA, Curiel DT: Engineering of adenovirus vectors containing heterologous peptide sequences in the C terminus of capsid protein IX. J Virol 76:6893-6899, 2002.

•  Hemminki A , Wang M, Desmond RA, Strong TV , Alvarez RD , Curiel DT: Serum and ascites neutralizing antibodies in ovarian cancer patients treated with intraperitoneal adenoviral gene therapy. Human Gene Therapy 13:1505-1514, 2002.

•  Hemminki A , Zinn KR , Liu B, Chaudhuri TR, Desmond RA, Rogers BE, Barnes MN, Alvarez RD, Curiel DT: In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus. J Natl Cancer Inst 94:741-749, 2002.

•  Kanerva A, Mikheeva GV, Krasnykh VN , Coolidge CJ, Lam JT, Mahasreshti PJ, Barker SD, Straughn M, Barnes MN , Alvarez RD , Hemminki A , Curiel DT: Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells. Clin Cancer Res 8:275-280, 2002.

•  Kanerva A, Wang M, Bauerschmitz GJ, Lam JT, Desmond RA, Bhoola SM, Barnes MN , Alvarez RD , Siegal GP, Curiel DT, Hemminki A : Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses. Mol Ther 5:695-704, 2002.

•  Kashentseva EA, Seki T, Curiel DT, Dmitriev IP : Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain. Cancer Res 62:609-616, 2002.

•  Kim M, Zinn KR , Barnett BG, Sumerel LA, Krasnykh VN , Curiel DT, Douglas JT: The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells. Eur J Cancer 38:1917-1926, 2002.

•  Ohtsuka T, Zhou T : Bisindolylmaleimide VII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. J Biol Chem 277:294-303, 2002.

•  Pereboev AV, Asiedu C, Kawakami K, Dong SS, Blackwell JL, Kashentseva EA, Triozzi PL , Aldrich WA , Curiel DT, Thomas JM, Dmitriev IP : Coxsackie virus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells. Gene Therapy 9:1189-1193, 2002.

•  Seki T, Dmitriev I , Kashentseva E, Takayama K, Rots M, Suzuki K, Curiel DT: Artificial extension of the adenovirus fiber shaft inhibits infectivity in coxsackievirus and adenovirus receptor-positive cell lines. J Virol 76:1100-1108, 2002.

•  Seki T, Dmitriev I , Suzuki K, Kashentseva E, Takayama K, Rots M, Uil T, Wu H, Wang M, Curiel DT: Fiber shaft extension in combination with HI loop ligands augments infectivity for CAR-negative tumor targets but does not enhance hepatotropism in vivo. Gene Therapy 9:1101-1108, 2002.

•  Wu H, Dmitriev I , Kashentseva E, Seki T, Wang M, Curiel DT: Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon. J Virol 76:12775-12782, 2002.

•  Wu H, Siki T, Dmitriev I , Uil T, Kashentseva E, Han T, Curiel DT: Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency. Human Gene Therapy 13:1647-1653, 2002.

•  Zaliauskiene L, Fazio RL, Kang S, Sparks K, Zinn KR , Weaver CT , Collawn JF: Inhibition of T cell responses by transferrin-coupled competitor peptides. Immunol Res 26:77-85, 2002.

•  Zaliauskiene L, Kang S, Sparks K, Zinn KR , Schwiebert LM, Weaver CT , Collawn JF: Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigens. J Immunol 169:2337-2345, 2002.

•  Zhou T , Mountz JD Jr, Kimberly RP: Immunobiology of tumor necrosis factor receptor superfamily. Immunol Res 26:323-336, 2002.

•  Zinn KR , Cao Z, Ma Z, Chaudhuri TR: Detection of ovarian cancer with a new plasmid vector encoding two reporters: Blood-based screening combined with imaging. Mol Ther 5:S77, 2002.

•  Zinn KR , Chaudhuri TR: Imaging adenovirus-mediated gene transfer. In: Curiel DT, Douglas JT (eds), Adenoviral Vectors for Gene Therapy. Academic Press, 2002.

•  Zinn KR , Chaudhuri TR: The type 2 human somatostatin receptor as a platform for reporter gene imaging. Eur J Nucl Med 29:388-399, 2002.

•  Zinn KR , Chaudhuri TR, Krasnykh VN , Buchsbaum DJ , Belousova N, Grizzle WE , Curiel DT, Rogers BE: Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice. Radiology 223:417-425, 2002.

•  Zinn KR , Krasnykh VN , Cao Z, Chaudhuri TR: Dual genetic reporter system for early diagnosis and monitoring of breast cancer. Breast Cancer Res Treat 76:S100, 2002.

2003

•  Atigadda VR , Vines KK, Grubbs CJ , Hill DL , Beenken SW , Bland KI , Brouillette WJ , Muccio DD : Conformationally defined retinoic acid analogs. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30). J Med Chem 46:3766-3769, 2003.

•  Barker SD, Coolidge CJ, Kanerva A, Hakkarainen T, Yamamoto M, Rivera AA, Bhoola SM, Barnes MN, Alvarez RD, Curiel DT, Hemminki A : The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy. J Gene Med 5:300-310, 2003.

•  Barker SD, Dmitriev, I , Nettelbeck DM, Lui B, Rivera AA, Bhoola SM, Barnes MN , Alvarez RD , Curiel DT, Hemminki A : Combined transcriptional and transductional targeting improves the specificity and efficacy of adenoviral gene delivery to ovarian carcinoma. Gene Therapy 10:1198-1204, 2003.

•  Beenken SW , Urist MM, Zhang Y, Desmond RA, Krontiras H , Medina H, Bland KI : Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer. Ann Surg 237:732-739, 2003.

•  Buchsbaum DJ , Zhou T , Grizzle WE , Oliver PG, Hammond CJ, Zhang S, Carpenter DM, LoBuglio AF : Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model. Clin Cancer Res 9:3731-3741, 2003.

•  Chaudhuri TR, Cao Z, Krasnykh VN , Stargel AV, Belousova N, Partridge EE, Zinn KR : Blood-based screening and light-based imaging for the early detection and monitoring of ovarian cancer xenografts. Technol Cancer Res Treat 2:171-179, 2003.

•  Forero-Torres A , Meredith, RF, Khazaeli MB, Carpenter DM, Shen S, Thornton J, Schlom J, LoBuglio AF : A novel monoclonal antibody design for radioimmunotherapy. Cancer, Biotherapy Radiopharm 18:751-760, 2003.

•  Forero A , Weiden PL , Vose JM, Knox SJ, LoBuglio AF , Hankins J, Goris ML, Picozzi VJ, Axworthy DB, Breitz HB, Sims RB, Ghalie RG, Shen S, Meredith RF : Phase I trial of a novel anti-CD20 fusion protein in pretargeted radioimmunotherapy for B-cell non-Hodgkin lymphoma. Blood 104:227-236, 2004, plus Journal cover.

•  Grubbs CJ , Hill DL , Bland KI , Beenken SW , Lin TH, Eto I, Atigadda VR , Vines KK, Brouillette WJ , Muccio DD : 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers. Cancer Letters 201:17-24, 2003.

•  Hakkarainen T, Hemminki A , Pereboev A, Barker S, Asiedu C, Strong TV , Kanerva A, Wahlfors J, Curiel DT: CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses. Clin Cancer Res 9:619-624, 2003.

•  Hemminki A , Kanerva A, Kremer EJ, Bauerschmitz GJ, Smith BF, Liu B, Wang M, Desmond RA, Keriel A, Barnett B, Baker HJ, Siegal GP, Curiel DT: A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model. Mol Ther 7:163-173, 2003.

•  Hemminki A , Kanerva A, Liu B, Wang M, Alvarez RD , Siegal GP, Curiel DT: Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression. Cancer Res 63:847-853, 2003.

•  Hemminki A , Wang M, Hakkarainen T, Desmond RA, Wahlfors JJ, Curiel DT: Production of EGFR targeting molecule from a conditionally replicating adenovirus impairs its oncolytic potential. Cancer Gene Ther 10:583-588, 2003.

•  Kanerva A, Zinn KR , Chaudhuri TR, Lam JT, Suzuki K, Uil TG, Hakkarainen T, Bauerschmitz GJ, Wang M, Liu B, Cao Z, Alvarez RD , Curiel DT, Hemminki A : Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor targeted oncolytic adenovirus. Mol Ther 8:449-458, 2003.

•  Krontiras H , Bland KI : When is sentinel node biopsy for breast cancer contraindicated? Surg Oncol 12:207-210, 2003.

•  Lam JT, Bauerschmitz GJ, Kanerva A, Barker SD, Straughn JM, Wang M, Barnes MN , Blackwell JL, Siegal GP, Alvarez RD , Curiel DT, Hemminki A : Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids. Cancer Gene Ther 10:377-387, 2003.

•  Liu K, Lin FT , Ruppert J , Lin WC : Regulation of E2F1 by BRCT-domain containing protein TopBP1. Mol Cell Biol 23:3287-3304, 2003.

•  Ohtsuka T, Buchsbaum DJ , Oliver P, Makhija S, Kimberly RP, Zhou T : Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway. Oncogene 22:2034-2044, 2003.

•  Rogers BE, Chaudhuri TR, Reynolds PN, Della Manna D, Zinn KR : Non-invasive gamma camera imaging of gene transfer using an adenoviral vector encoding an epitope-tagged receptor as a reporter. Gene Ther 10:105-114, 2003.

•  Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS : High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 170:998-1002, 2003.

•  Uil TG, Seki T, Dmitriev I , Kashentseva E, Douglas JT, Rots MG, Middeldorp JM, Curiel DT: Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob. Cancer Gene Ther 10:121-124, 2003.

•  Xu Y, Szalai AJ, Zhou T , Zinn KR , Chaudhuri TR, Li X, Koopman WJ, Kimberly RP: FcgammaRs modulate cytotoxicity of anti-Fas antibodies: Implications for agonistic antibody-based therapeutics. J Immunol 171:562-568, 2003.

•  Zinn KR , Chaudhuri TR, Stargel AV, Kumar S, Ponnazhagan S: Gamma camera imaging of Tc-99m-labeled AAV vector followed by bioluminescence imaging of luciferase transgene expression. Mol Ther 7:S184, 2003.

2004

•  Glasgow JN, Kremer EJ, Hemminki A , Siegal GP, Douglas JT, Curiel DT: An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism. Virology 324:103-116, 2004.

•  Kanerva A, Bauerschmitz GJ, Yamamoto M, Lam JT, Alvarez RD, Siegal GP, Curiel DT, Hemminki A : A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma. Gene Ther 11:552-559, 2004.

•  Le LP, Everts M, Dmitriev IP , Davydova JG, Yamamoto M, Curiel DT: Fluorescently labeled adenovirus with pIX-EGFP for vector detection. Mol Imaging 3:105-116, 2004.

•  Pandya A, Talley LI , Frost AR , Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng CF , Grizzle WE , Krontiras H , Bland KI , LoBuglio AF , Ruppert SM , Ruppert J : Nuclear localization of KLF4 is associated with an aggressive phenotype in early stage breast cancer. Clinical Cancer Res 10:2709-2719, 2004.

2004 In Press

•  Bland KI , Krontiras H : Wound care and complications of mastectomy. In: Bland KI (ed), Breast 3rd Ed, W.B. Saunders, 2004, In Press.

•  Buchsbaum DJ , Khazaeli MB , LoBuglio AF , Axworthy DS, Schultz J, Chaudhuri TR, Zinn KR : Imaging and biodistribution of pretargeted CC49sFv4/SA fusion protein and radiolabeled DOTA-biotin in an intraperitoneal tumor model. Clin Cancer Res, 2004, In Press.

•  Krontiras H , De Los Santos JF, Bland KI : Breast conservation therapy in invasive breast cancer. In: Bland KI (ed), Breast 3rd Edition, W.B. Saunders, 2004, In Press.