DEVELOPMENTAL RESEARCH PUBLICATIONS :

2000

•  Hampton TA, Conry RM, Khazaeli MB , Shaw DR , Curiel DT, LoBuglio AF , Strong TV : SEREX analysis for tumor antigen identification in a mouse model of adenocarcinoma. Cancer Gene Therapy 7:446-455, 2000.

•  Kimler BF , Fabian CJ, Wallace DD: Breast cancer chemoprevention trials using the fine-needle aspiration model. J Cell Biochem (Suppl) 34:7-12, 2000.

•  Krasnykh VN , Dmitriev I , Navarro JG, Belousova N, Kashentseva E, Xiang J, Douglas JT, Curiel DT: Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res 60:6784-6787, 2000.

•  Krasnykh VN , Douglas JT, van Beusechem VW: Genetic targeting of adenoviral vectors. Molecular Therapy 1:391-405, 2000.

•  Strong TV : Gene therapy for carcinoma of the breast: Genetic immunotherapy. Breast Cancer Res 2:15-21, 2000.

2001

•  Beenken SW , Grizzle WE , Crowe DR, Conner MG, Weiss HL, Sellers MT, Krontiras H , Urist MM, Bland KI: Molecular biomarkers for breast cancer prognosis: Co-expression of c-erbB-2 in p53. Annals of Surgery 233:630-638, 2001.

•  Fabian CJ, Kimler BF : Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. Ann NY Acad Sci 952:44-59, 2001.

•  Fabian CJ, Kimler BF : Breast cancer risk prediction: Should nipple aspiration fluid cytology be incorporated into clinical practice? J Natl Cancer Inst 93:1762-1763, 2001.

•  Fabian CJ, Kimler BF : Chemoprevention for high-risk women: Tamoxifen and beyond. Breast J 7:311-320, 2001.

•  Huang YZ, Wang Q, Xiong WC, Mei L : Erbin is a protein concentrated at postsynaptic membranes that regulates surface expression of ErbB2. J Biol Chem 276:19318-19326, 2001.

•  Krasnykh VN , Belousova N, Korokhov N, Mikheeva G, Curiel DT: Genetic targeting of adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol 75:4176-4183, 2001.

•  Lecureur V, Thottassery JV , Zambetti GP, Sun D, Schuetz EG, Schuetz JD: Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo . Oncogene 20:303-313, 2001.

•  Morrow M, Krontiras H : Who should not receive chemotherapy? Data from American databases and trials. J Natl Cancer Inst (Monographs) 30:109-113, 2001.

•  Poole JC, Andrews LG, Tollefsbol TO : Activity, function and gene regulation of the catalytic subunit of telomerase (hTERT). Gene 269:1-12, 2001.

•  Ren XR, Du QS, Huang YZ, Ao SZ, Mei L , Xiong WC: PSGAP, a novel PH and SH3 domain containing rhoGAP protein, interacts with PYK2 and FAK. J Cell Biol 152:971-984, 2001.

•  Suzuki K, Fueyo J, Krasnykh VN , Reynolds PN, Curiel DT, Alemany R: A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin Cancer Res 7:120-126, 2001.

•  Thummel KE, Brimer C, Yasuda K, Thottassery JV , Senn T, Lin Y, Ishizuka H, Kharasch E, Schuetz J, Schuetz E: Transcriptional control of intestinal CYP3A4 by 1-alpha,25-dihydroxy vitamin D3. Mol Pharmacol 60:1399-1406, 2001.

•  Tollefsbol TO , Andrews LG: Mechanisms for telomerase gene control in aging cells and tumorigenesis. Med Hypotheses 56:630-637, 2001.

•  Wang-Johanning F, Frost AR , Johanning GL, Khazaeli MB, LoBuglio AF , Shaw DR, Strong TV : Expression of human endogenous retrovirus K envelope transcripts in human breast cancer. Clin Cancer Res 7:1553-1560, 2001.

•  Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L , Wu JY, Xiong WC, Rao Y: Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107:209-221, 2001.

2002

•  Alvarez J, Sohn P, Zeng X, Doetschman T, Robbins DJ, Serra R : TGF-beta-2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development 129:1913-1924, 2002.

•  Bauerschmitz GJ, Lam JT, Kanerva A, Suzuki K, Nettelbeck DM, Dmitriev I , Krasnykh VN , Mikheeva GV, Barnes MN , Alvarez RD , Dall P, Alemany R, Curiel DT, Hemminki A : Treatment of ovarian cancer with a tropism modified oncolytic adenovirus. Cancer Res 62:1266-1270, 2002.

•  Belousova N, Krendelchtchikova V, Curiel DT, Krasnykh VN : Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol 76:8621-8631, 2002.

•  Bryant R, Tollefsbol TO : The effects of all-trans 9-cis and UAB30 retinoic acids on human breast cancer cells. McNair Chronicle 3:24-26, 2002.

•  Chaudhuri TR, Krasnykh VN , Cao Z, Zinn KR : Dualistic genetic reporter system for early diagnosis and monitoring of ovarian cancer. Mol Ther 5:S207, 2002.

•  Ellis RJ, Fabian CJ, Kimler BF , Tawfik O, Mayo MS, Decelis CR, Jewell WR, Connor C, Modrell C, Praeger M, McGinness M, Mehta R, Fruehauf JP: Factors associated with success of the extreme drug resistance assay in primary breast cancer specimens. Breast Cancer Res Treat 71:95-102, 2002.

•  Fabian CJ, Kimler BF : Breast cancer chemoprevention: Current challenges and a look toward the future. Clin Breast Cancer 3:113-124, 2002.

•  Fabian CJ, Kimler BF : Chemoprevention of breast cancer: Implications for postmenopausal women. Drugs & Aging 19:43-78, 2002.

•  Fabian CJ, Kimler BF , Brady DA, Mayo MS, Chang CHJ, Ferraro JA, Zalles CM, Stanton AL , Masood S, Grizzle WE , Boyd NF, Arneson DW, Johnson KA: A phase II breast cancer chemoprevention trial of oral alpha-DFMO: Breast tissue, imaging and serum and urine biomarkers. Clin Cancer Res 8:3105-3117, 2002.

•  Fabian CF, Lukert B, Chamberlain C, Anderson J, Mayo MS, Kimler BF , Johnson KA: Effects of arzoxifene, a third generation SERM, on serum osteocalcin levels and bone mineral density in pre- and post-menopausal women at increased risk for breast cancer. Proc Am Assoc Cancer Res 43:822, 2002.

•  Hemminki A , Wang M, Desmond RA, Strong TV , Alvarez RD , Curiel DT: Serum and ascites neutralizing antibodies in ovarian cancer patients treated with intraperitoneal adenoviral gene therapy. Human Gene Therapy 13:1505-1514, 2002.

•  Kanerva A, Mikheeva GV, Krasnykh VN , Coolidge CJ, Lam JT, Mahasreshti PJ, Barker SD, Straughn M, Barnes MN , Alvarez RD , Hemminki A , Curiel DT: Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells. Clin Cancer Res 8:275-280, 2002.

•  Kim M, Zinn KR , Barnett BG, Sumerel LA, Krasnykh VN , Curiel DT, Douglas JT: The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells. Eur J Cancer 38:1917-1926, 2002.

•  Kim S-O, Loesch K, Wang X, Jiang J, Mei L , Cunnick JM, Wu J, Frank SJ: A potential role for Grb2-associated binder (Gab)-1 in growth hormone signaling. Endocrinology 143:4856-4867, 2002.

•  Lee HJ, Jung KM, Huang YZ, Bennett LB, Lee JS, Mei L , Kim TW: Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem 277:6318-6323, 2002.

•  Lopatina N, Haskell JF, Andrews LG, Poole JC, Saldanha S, Tollefsbol TO : Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts. J Cell Biochem 84:324-334, 2002.

•  Luo ZG, Wang Q, Zhou JZ, Wang J, Luo Z, Liu M, He X, Wynshaw-Boris A, Xiong WC, Lu B, Mei L : Regulation of AChR clustering by disheveled interacting with MuSK and PAK1. Neuron 35:489-505, 2002.

•  Rodriguez-Buford C , Barnes MN , Oeschlager DK, Myers RB, Talley LI , Partridge EE, Grizzle WE : Effects of non-steroidal anti-inflammatory agents (NSAIDS) on ovarian carcinoma cell lines: Preclinical evaluation of NSAIDS as chemopreventive agents. Clin Cancer Res 8:202-209, 2002.

•  Talley LI , Grizzle WE , Waterbor JW, Brown D, Weiss HL, Frost AR : Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and post-menopausal women. Int J Cancer 98:118-127, 2002.

•  Zinn KR , Chaudhuri TR, Krasnykh VN , Buchsbaum DJ , Belousova N, Grizzle WE , Curiel DT, Rogers BE: Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice. Radiology 223:417-425, 2002.

•  Zinn KR , Krasnykh VN , Cao Z, Chaudhuri TR: Dual genetic reporter system for early diagnosis and monitoring of breast cancer. Breast Cancer Res Treat 76:S100, 2002.

2003

•  Ahmed A, Tollefsbol TO : Telomeres, telomerase and telomerase inhibition: Clinical implications for cancer. J Amer Geriatrics Soc 51:116-122, 2003.

•  Beenken SW , Urist MM, Zhang Y, Desmond RA, Krontiras H , Medina H, Bland KI : Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer. Ann Surg 237:732-739, 2003.

•  Belousova N, Korokhov N, Krendelshchikova V, Simonenko V, Mikheeva G, Triozzi PL , Aldrich WA , Banerjee PT, Gillies SD, Curiel DT, Krasnykh V : Genetically targeted adenovirus vector directed to CD40-expressing cells. J Virol 77:11367-11377, 2003.

•  Casillas M, Brotherton SL, Andrews LG, Ruppert J , Tollefsbol TO : Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements. Gene 316:57-65, 2003

•  Casillas MA Jr, Lopatina N, Andrews LG, Tollefsbol TO : Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem 252:33-43, 2003.

•  Chaudhuri TR, Cao Z, Krasnykh VN , Stargel AV, Belousova N, Partridge EE, Zinn KR : Blood-based screening and light-based imaging for the early detection and monitoring of ovarian cancer xenografts. Technol Cancer Res Treat 2:171-179, 2003.

•  Chhieng DC , Marley EF, Tabbara SO, Talley LI , Frost AR : Microvessel density and vascular endothelial growth factor expression in infiltrating lobular mammary carcinoma. Breast J 9:200-207, 2003.

•  Hakkarainen T, Hemminki A , Pereboev A, Barker S, Asiedu C, Strong TV , Kanerva A, Wahlfors J, Curiel DT: CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses. Clin Cancer Res 9:619-624, 2003.

•  Hansen NJ , Poole JC, Andrews LG, Tollefsbol TO : Telomerase: structure and function. In: Cooper DN (ed), Nature's Encyclopedia of the Human Genome, Nature Publishing Group, London, 5, 478-483, 2003.

•  Huang YZ, Zang M, Xiong WC, Luo Z, Mei L : Erbin suppresses the MAP kinase pathway. J Biol Chem 278:1108-1114, 2003.

•  Kawakami Y, Li H, Lam JT, Krasnykh VN , Curiel DT, Blackwell JL: Substitution of the adenovirus serotype 5 knob with a serotype 3 knob enhances multiple steps in virus replication. Cancer Res 63:1262-1269, 2003.

•  Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, Krendelshchikova V, Pereboev A, Kotov A, Kotova O, Triozzi PL , Aldrich WA , Douglas JT, Lo KM, Banerjee PT, Gillies SD, Curiel DT, Krasnykh V : Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge. J Virol 77:12931-12940, 2003.

•  Krontiras H , Bland KI : When is sentinel node biopsy for breast cancer contraindicated? Surg Oncol 12:207-210, 2003.

•  Lopatina NG, Poole JC, Saldanha S, Hansen NJ , Key JS, Pita M, Andrews LG, Tollefsbol TO : Control mechanisms in the regulation of hTERT expression in differentiating human teratocarcinoma cells. Biochem Bioph Res Comm 306:650-659, 2003.

•  Merrell M, Suarez-Cuervo C, Harris KW , Vaananen HK, Selander K: Bisphosphonate induced growth inhibition of breast cancer cells is augmented by p38 inhibition. Breast Cancer Res Treat 81:231-241, 2003.

•  Rodriguez-Burford C , Oelschlager DK, Talley LI , Barnes MN , Partridge EE, Grizzle WE : The use of dimethyl sulfoxide (DMSO) as a vehicle in cell culture experiments using ovarian carcinoma cell lines. J Biotech & Histoch 78:17-21, 2003.

•  Saldanha S, Andrews LG, Tollefsbol TO : Analysis of telomerase activity and detection of its catalytic subunit, hTERT. Analytical Biochem 315:1-21, 2003.

•  Saldanha SN, Andrews LG, Tollefsbol TO : Assessment of telomere length and factors that contribute to its stability. Eur J Biochem 270:389-403, 2003.

•  Shevde-Samant L , Welch DR : Metastasis suppressor pathways – an evolving paradigm. Cancer Letters 198:1-3, 2003.

•  Suarez Cuervo C, Harris KW , Kallman L, Vaananen HK, Selander K: Tumor necrosis factor alpha induced interleukin-6 production requires ERK1 activation in breast cancer cells. Breast Cancer Res Treat 80:71-78, 2003.

•  Takayama K, Reynolds PN, Short JJ, Kawakami Y, Adachi Y, Glasgow JN, Rots MG, Krasnykh VN , Douglas JT, Curiel DT: A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism. Virology 309:282-293, 2003.

•  Yamamoto M, Davydova J, Wang M, Siegal GP, Krasnykh VN , Vickers SM, Curiel DT: Infectivity enhanced cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology 125:1203-1218, 2003.

2004

•  Bailey JP, Nieport KM, Herbst MP, Srivastava S, Serra R , Horseman ND : Prolactin and transforming growth factor-beta signaling exert opposing effects on mammary gland morphogenesis, involution, and the Akt-forkhead pathway. Mol Endocrinol 18:1171-1184, 2004.

•  Casillas MA, Lopatina N, Andrews LG, Tollefsbol TO : Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem 252:33-43, 2003.

•  Du F, Chu WJ, Yang B, den Hollander JA, Ng TC : In vivo GABA detection with improved selectivity and sensitivity by localized double quantum filter technique at 4.1T. J Magn Reson Imaging 22:103-108, 2004.

•  Fabian CJ, Kimler BF , Anderson J, Tawfik OW, Mayo MS, Burak WE Jr, O'Shaughnessy JA, Albain KS, Hyams DM, Budd GT, Ganz PA, Sauter ER, Beenken SW , Grizzle WE , Fruehauf JP, Arneson DW, Bacus JW, Lagios MD, Johnson KA, Browne D: Breast cancer chemoprevention phase I evaluation of biomarker modulation arzoxifene, a third generation selective estrogen receptor modulator. Clin Cancer Res 10:5403-5417, 2004.

•  Harms JF, Welch DR , Samant RS , Shevde-Samant LR , Miele ME, Babu GR, Goldberg SF, Gilman VR, Sosnowski DM, Campo DA, et al.: A small molecule antagonist of the alpha-v-beta-3 integrin suppresses MDA-435 skeletal metastasis. Clin Exp Metastasis 21:119-128, 2004.

•  Jaeger EB, Chekmareva MA, Tennant TR, Luu HH, Hickson JA, Chen SL, Samant RS , Sokoloff MH, Rinker-Schaeffer CW: Inhibition of prostate cancer metastatic colonization by approximately 4.2 Mb of human chromosome 12. Int J Cancer 108:15-22, 2004.

•  Meehan WJ, Samant RS , Hopper JE, Carrozza MJ, Shevde LA, Workman JL, Eckert KA, Verderame MF, Welch DR : Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. J Biol Chem 279:1562-1569, 2004.

•  Mittal A, Pate MS, Wylie RC, Tollefsbol TO , Katiyar SK : EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int J Oncol 24:703-710, 2004.

•  Muminova Z, Strong TV , Shaw DR : Characterization of human mesothelin transcripts in pancreatic and ovarian cancer. BMC Cancer 4:19, 2004.

•  Pandya A, Talley LI , Frost AR , Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng CF , Grizzle WE , Krontiras H , Bland KI , LoBuglio AF , Ruppert SM , Ruppert J : Nuclear localization of KLF4 is associated with an aggressive phenotype in early stage breast cancer. Clinical Cancer Res 10:2709-2719, 2004.

•  Ponnazhagan S, Mahendra G, Lima J, Aldrich W, Jenkins C, Ren C, Kumar S, Kallman L, Strong TV , Shaw DR, Triozzi PL: Augmentation of anti-tumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvants. Human Gene Ther 15:856-864, 2004.

•  Qu Z, Thottassery JV , Van Ginkel S, Manuvakhova M, Westbrook L, Roland-Lazenby C, Hays S, Kern FG: Homogenieity and long-term stability of tetracycline-regulated gene expression with low basal activity by using the rtTA2S-M2 transactivator and insulator-flanked reporter vectors. Gene 327:61-73, 2004.

•  Samant RS , Meehan WJ, Hopper JE, Workman JL, Carrozza MJ, Shevde-Samant LR , Verderame MF, Eckert KE, Welch DR : Interaction of the BRMS1 metastasis suppressor with RBP1 and mSin3 histone deacetylase complex. J Biol Chem 279:1562-1569, 2004.

•  Straughn JM, Shaw DR, Guerrero A, Bhoola SM, Racelis A, Wang Z, Chiriva-Internati M, Grizzle WE , Alvarez RD, Lim SH, Strong TV : Expression of sperm protein 17 (Sp17) in ovarian cancer. International J Cancer 108:805-811, 2004.

•  Thottassery JV , Sun Y, Westbrook L, Rentz S, Manuvakhova M, Qu Z, Samuel S, Upshaw R, Poe A, Kern FG: Prolonged ERK1/2 activation during FGF-1 or heregulin b 1 induced antiestrogen-resistant growth of breast cancer cells is resistant to MEK inhibitors. Cancer Res 64:4637-4647, 2004.

2004 In Press

•  Bland KI , Krontiras H : Wound care and complications of mastectomy. In: Bland KI (ed), Breast 3 rd Ed, W.B. Saunders, 2004, In Press.

•  Fabian CJ, Kimler BF , Mayo SM, Grizzle WE , Masood S, Ursin G: Clinical approaches to the discovery and testing of new breast cancer prevention drugs. Cancer Chemoprevention 2: Strategies for Chemoprevention, 2004, In Press.

•  Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, Krendelshchikova V, Pereboev A, Kotov A, Kotova O, Triozzi PL , Aldrich WA , Banerjee P, Curiel DT, Krasnykh VN : Targeting of adenovirus via a protein bridge approach combined with genetic modification of the viral capsid. J Virol, 2004, In Press.

•  Krontiras H , De Los Santos JF, Bland KI : Breast conservation therapy in invasive breast cancer. In: Bland KI (ed), Breast 3 rd Edition, W.B. Saunders, 2004, In Press.

•  Lima J, Jenkins C, Hamilton N, Triozzi PL, Shaw DR, Strong TV : A DNA vaccine encoding genetic fusions of CEA and GM-CSF. J Immunother, 2004, In Press.

•  Serra R , Crowley M: TGF-betas in mammary gland development and breast cancer. Breast Disease, 2004, In Press.

•  Straughn JM, Shaw DR , Strong TV : Some remarks the somatic expression of Sperm Protein 17. Letter to the Editor: Response to the Letter to the Editor, Int J Cancer, 2004, In Press.

•  Timares L, Pustilnik TB, Hemminki A , Perebeov A, Krasnykh VN , Tillman B, Alvarez RD, Curiel DT: Adenovirus-modified dendritic cell-based vaccines. Mol Cancer Therapy, 2004, In Press.