Received initial funding in 2011
Xu Feng, PhD (UAB, Department of Molecular & Cellular Pathology)
Identification of Anti-RANK Signaling Compounds via HTS of Cell-Based Assays for Preventing and Treating Cancer Bone Metastases
David Schneider, PhD (UAB, Department of Biochemistry and Molecular Genetics)
Developing a fully-reconstituted human RNA Polymerase I transcription assay for drug screening
Corinne Griguer, PhD (UAB, Department of Surgery)
Cytochrome c oxidase inhibitors: Novel therapeutic approach to prevent / reverse cancer chemoresistance
*Louise Hecker, PhD (UAB, Department of Medicine)
Identification of Small Molecule Inhibitors Targeting NOX4
Joanne Murphy-Ullrich, PhD (UAB, Department of Molecular & Cellular Pathology)
Development of small molecule antagonists for blockade of TSP1-dependent TGFbeta activation for treatment of multiple myeloma
Erik Roberson, MD, PhD (UAB, Department of Neurology)
Targeting the Tau–Fyn Interaction in Alzheimer’s Disease
*William Parker, PhD (Southern Research) and Jaideep Thottassery, PhD (Southern Research)
Novel DNA Demethylating Nucleosides: T-dCyd, 5F- T-dCyd and 5-Aza-T-dCyd
Received initial funding in 2010
Stephen Aller, PhD (UAB, Department of Pharmacology & Toxicology)
In silico screening and structure-based drug design for inhibitors of a multi-drug resistance transporter
*John Chatham, PhD (UAB, Department of Medicine) and Richard Marchase, PhD (UAB, Department of Cell Biology)
Prevention of stress-induced cellular calcium overload by inhibition of STIM1 mediated calcium entry pathways: A new therapy for ischemic injury
*Olaf Kutsch, PhD (UAB, Department of Medicine)
Hit & run stimulation to reactivate latent HIV-1 infection
Robert van Waardenburg, PhD (UAB, Department of Pharmacology & Toxicology)
Identification of small molecule poisons of the DNA repair protein Tyrosyl-DNA Phosphodiesterase I (TDP1)
Talene Yacoubian, MD, PhD (UAB, Department of Neurology)
Screening for inducers of 14-3-3theta expression for treatment of Parkinson’s Disease
Received initial funding in 2009
*W. Timothy Garvey, MD (UAB, Department of Nutrition Sciences) and Yuchang Fu, PhD (UAB, Department of Nutrition Sciences)
NR4A3 Orphan Nuclear Receptor as a Target for the Treatment of Insulin Resistance
*Krister Wennerberg, PhD (Southern Research Institute)
Discovery and Development of Ect2 Inhibitors as Anti-Cancer Drugs
*Andrew West, PhD (UAB, Department of Neurology)
Discovery of LRRK2 kinase inhibitors for treatment of Parkinson’s Disease
Sadanandan Velu, PhD (UAB, Department of Chemistry)
Novel Marine Alkaloid Analogs for Breast Cancer Therapy
Received initial funding in 2008
Scott Blume, PhD (UAB, Department of Medicine; Division of Hematology & Oncology)
A Strategy to Specifically Modulate the Translation of Individual Cancer-Relevant Genes
Lawrence J. DeLucas, OD, PhD (UAB, Department of Optometry)
USP2a, a Deubiquitinating Protein Implicated in Prostate Cancer
*L. Burt Nabors, MD (UAB, Department of Neurology)
The Post-transcriptional Regulator, HuR, as a Novel Therapeutic Target in Malignant Glioma