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Mindful of the strengths of a variety of MODEL SYSTEMS relative to scientific goals, a diverse team of investigators have been assembled to provide consultation about experimental design that can leverage several different organisms, not limited to zebrafish, Drosophila, C. elegans, rats, mice, and other mammalian species. In this way, findings in recent genetic and genomic studies have been brought back to models for functional assay, leveraging state-of-the-art methods (e.g., CRISPR) in transgenic animal design. In addition, a broad array of animal facilities is available for high-quality care, imaging, and pathology/phenotyping.
Animal Resource Program (UAB)
This Program is the service unit that provides care for all animals required in research and teaching programs at UAB and affiliated hospitals. Services include animal procurement; daily care; quarantine, testing, health surveillance, and veterinary medical care; provision of facilities and personnel for procedures such as surgery, radiography, postoperative care, necropsy, and diet preparation; assuring compliance with animal use laws and policies; and assisting with research and teaching programs that use animals.
Comparative Pathology Laboratory (UAB)
The Laboratory supports the Animal Resources Program animal care and health surveillance programs, and assists investigators in achieving their specialized animal research objectives. Staffed by two certified histology technicians and two board certified veterinary pathologists, the Laboratory has modern equipment to perform all anatomic and clinical pathologic, microbiologic, parasitologic, and other procedures necessary to fulfill its mission.
Experimental Biomechanics Core (UAB)
The mission of this core is to provide collaborating investigators with state-of-the-art equipment and trained personnel to facilitate mechanical testing and measurement of mechanical properties of biological and man-made materials, structures and constructs.
Gnotobiotic and Genetically-Engineered Mouse Core (UAB)
This Core is composed of a Gnotobiotic Unit and a Genetically-Engineered Mouse Unit. The purposes of the Core are to generate and provide gnotobiotic and genetically engineered mice to research projects and to provide specialized breeding, marker-assisted genotyping, and histopathologic evaluation services for studies using these mice. The Mouse Unit unit provides a designer breeding service to develop unique mouse "reagents" for use in fundamental studies. It also provides consultation with investigators to develop and implement breeding strategies for the generation of unique genotypes.
Human to Model (H2M) Systems (UAB)
The H2M Systems Core provides a variety of educational and consulting forums designed to facilitate the reciprocal exchange of scientific information between the investigator and core personnel. Through this Core, investigators learn about a wide variety of options available to create and study model organisms, and receive input from experts currently using different genetic models. The Core also serves as an advocate for investigators as core personnel become educated on the experimental needs of the investigator.
PKD Engineered Models Resource Core (UAB)
One of the primary objectives of this Core is to develop and disseminate important mouse resources related to cystic kidney disorders. The Core continues to build important mouse resources with six new conditional mutant lines in production. These include three genes known to cause Meckel-Gruber Syndrome (MKS) and one involved in Nephronophthisis (NPHP). Conditional alleles for these genes are not currently available from any other source. Since many of these mutants are generally lethal during early development it is not possible to analyze the role in later development or in postnatal stages without conditional alleles. All together, the core has established 24 different mouse mutants in cilia related genes and has generated several of the corresponding embryonic fibroblast or renal cell lines for in vitro analysis.
Zebrafish Facility Resource (UAB)
This Facility is a core resource with 5,000 net square feet located in the Research Support Building. It includes recirculating aquaria systems with a central water conditioning/purification system supplying 27 racks (>2200 3 L tank capacity). The in vitro manipulation laboratory includes four embryos injection stations, a pipette puller, a fluorescent scope and camera, a cell press, breeding equipment, and support supplies. This resource is open to all researchers using zebrafish as a research model.
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The UAB CCTS is supported through the
National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program
, grant UL1 TR000165.The CTSA program is led by the NIH’s
National Center for Advancing Translational Sciences (NCATS)
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