The mission of the Center for Clinical and Translational Science (CCTS) is to address disparities in diseases disproportionately represented within the Deep South as we accelerate discovery to improve human health. Through the CCTS Partner Network Multidisciplinary Pilot Program, we seek to foster collaboration, team science and innovative discovery.


The CCTS invites letters of intent that address scientific questions consistent with the Center’s mission at any “stage of research along the path from the biological basis of health and disease to interventions that improve the health of individuals and the public” as described in NCATS’ Translational Science Spectrum. Proposals to investigate the operational principles underlying each step of the translational process are also strongly encouraged. Special consideration will be given to those projects that bring together investigators across two or more partner institutions and to applications that address scientific questions of particular importance to the health of our communities, including health disparities and health challenges across the life course.

Special consideration will be given to those projects that bring together investigators across two or more partner institutions.  Priority will also be given to applications that address scientific questions of particular importance to the health of our communities, including health disparities and health challenges across the life course, as well as applications that involve community-based participatory research (CBPR), medical device development, population health investigation or innovative approaches to promote efficiency in participant recruitment to clinical studies.

KEY DATES:
Posted Date September 6, 2016
Letter of Intent (LOI) Due Date October 17, 2016, 5pm CT
Invitation to Submit Full Application November 21, 2016
Full Application Due Date January 16, 2017, 5pm CT
Award Announcements Expected April 1, 2017

Eligibility: 
This program is primarily intended to support full-time faculty who are early investigators (please see NIH definition). Applications will also be accepted from established investigators with a previous history of funding with justification of eligibility. PIs must be based at any one of the 11 CCTS Partner Institutions.

This program is intended to support investigators with a full-time faculty appointment. Postdocs may be eligible if a faculty appointment at a CCTS Partner institution is on the horizon, with a start date on or before April 1, 2017 – as part of the application, the investigator should include a letter from the Department Chair reflecting such. 

More established investigators must comment on how the proposed research represents the first effort to pursue human subjects research. They are also encouraged to apply if the application advances ongoing research to a later stage of translation.

Funding: Applicants may request up to $60,000 Direct Costs, with the CCTS Hub committing up to half. Cosponsoring funds are expected to match CCTS funds. Awards are limited to 12 months in duration. Applicants are encouraged to identify at least one non-CCTS cosponsor with shared scientific interests. A cosponsor may include a school, a department, a division, a University-wide Interdisciplinary Research Center, etc., or a combination thereof, based at the PI’s home institution. As part of the Letter of Intent (LOI), please list all potential cosponsors in the designated application form – formal letters of support are not required during the LOI phase.  


Study Design Considerations: Special methodology considerations are essential in the design of a pilot study – these are not mini-R01s! We urge all applicants to watch Design of Pilot Studies (video and references).

Two-Phase Application Process


We strongly urge applicants to read the entire Request for Proposal and Application Guidelines before starting the application process. 

(1) 
Letter of Intent (LOI) Phase: An LOI is required by this mechanism. An LOI application form is available only upon request – please contact CCTS Research Commons (205.934.7442 or ccts@uab.edu).

LOIs will be rated on the NIH 9-point scale. The highest rated proposals will be invited to submit a full proposal.

Submission. Submit your LOI form as a single PDF to ccts@uab.edu before the deadline (October 17, 2016, 5pm CT).

(2) Full Application Phase: PIs selected to submit a full proposal will be notified in November 2016 (please see Key Dates). Proposals will be rated on the NIH 9-point scale. The highest rated proposals will be referred to the CCTS Executive Council, which will make final award decisions. Award announcements are anticipated on April 1, 2017.

Consultation.  Applicants invited to the second phase will be expected to engage consultation specific to the proposed aims and related to project design, regulatory considerations, and other expertise. Budgeting of any core service or shared expertise requires sign-off by that facility. Please connect with these groups through CCTS Research Commons (ccts@uab.edu; 205.934.7442). Please use the consultation form in the 2017_CCTSNETWORKPilot_FULLpackage__v20161116-01.pdf to address this requirement.

Submission:  Submit your full application package as a PDF to ccts@uab.edu before the deadline (January 16, 2017 , 5pm CT). The package should be a single PDF, including the components listed above. 

Please address any questions to CCTS Research Commons: 205.934.7442 or ccts@uab.edu.