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Technology is available to perform cutting-edge IMAGING & CELL ANALYSIS in addition to molecular characterization and animal phenotyping. Imaging capacities include 7T MRI, fluorescence microscopy, confocal laser microscopy, time lapse, live cell, FRET, FRAP, EM, Cryo-EM, super-resolution/spectral imaging, and light microscopy. Immunoreagent development and advanced cytometry is also available.
Cell and Microscopic Analysis
Cellular and Biomolecular Imaging Facility (USA)
This Facility provides a broad platform of technologies for imaging fixed or living cells and tissues. The technologies offered include sub-diffraction limit super-resolution imaging via Structured Illumination (SIM) or Stochastic Optical Reconstruction (STORM) microscopy; spectral, confocal and widefield fluorescence imaging; color imaging for histology; and an MMI CellCut Plus laser micro-dissection system. Some of our microscope systems are equipped with environmental chambers and perfect focus systems allowing for extended time-lapse imaging of living cells. We also support a range of microscope-based experimental techniques, including simultaneous photostimulation and imaging for use withphotoactivatable proteins or in FRAP (Fluorescent Recovery after Photobleaching) experiments, as well as fluorescent techniques for detecting protein-protein interactions in living cells such as FRET (Foerster resonance energy transfer) or BIFC (bi-molecular fluorescent complementation).
Comprehensive Flow Cytometry Core (UAB)
The mission of this Core is to provide state-of-the-art cell sorting and analytical flow cytometry services to support research programs. The Core encourages collaborations and synergy. A variety of services and equipment is available at two locations - the Bevill Biomedical Research Building and the Shelby Biomedical Research Building.
Epitope Recognition and Immunoreagent Core (UAB)
This Core consists of a hybridoma lab and phage display labs. In addition to supplying traditional hybridoma services, it provides investigators with novel approaches for monoclonal antibody (mAb) development as well as expertise in immunoassay design, epitope characterzation, and phage display technology. The Core produces and distributes a variety of frequently used monoclonal reagents (i.e., anti-tag reagent, anti-mouse, or human CD antigens) at highly economical prices.
High Resolution Imaging Facility (UAB)
This Facility provides a variety of cutting-edge microscopy services. Investigators conducting experiments that require the use of high end digital microscopes can benefit from the facility’s diverse applications. Fluorescence Microscopy, Confocal Laser Microscopy, Time Lapse, FRET, FRAP, Electron Microscopy, Cryo-EM Microscopy and Light Microscopy are just a few examples of techniques available. Consultation and training are also available.
Histomorphometry and Molecular Analysis Core (UAB)
This Core provides state-of-the-art histology and histomorphometric analysis of bone samples. Processing bone tissue requires highly specialized techniques, unique equipment, and technical expertise. Histological sections may be obtained on fresh frozen bones, decalcified and paraffin-embedded bones, or on non-decalcified, plastic-embedded bones. We also process all types of biomaterials, including engineering scaffolds.
Imaging of Animals
Small Animal Imaging Shared Facility (UAB)
This facility was established so researchers could apply non-invasive, molecular imaging technologies in animal models. A range of imaging modalities are used, including gamma camera imaging, X-ray CT, microPET/CT, microSPECT/CT, bioluminescence, fluorescence, magnetic resonance (MR) imaging, and ultrasound imaging.
Small Animal In Vivo Imaging (Auburn)
This Laboratory provides consultation and resources for studies involving the fine structure of cells, tissues, small animals, and non-biological materials using state-of-the-art microscopic, x-ray, luminescent, and fluorescent imaging and image analysis tools. It offers access to a laser capture microdissection workstation, Nuance FX multispectral analyzer, dissecting microscope, and IVIS Lumina XR small animal imaging system.
Small Animal Phenotyping (UAB)
The Core provides in vivo body composition assessment for a variety of small animals using dual-energy X-ray absorptiometry, quantitative magnetic resonance and micro-computed tomography. Direct analysis of carcasses can also be performed on mice and rats using chemical extraction. The Core has a mouse phenotyping set up for the measurement of oxygen consumption, carbon dioxide production, locomotor activity, and food intake. It has recently established an Aquatic Animal Research Core to facilitate research using important aquatic animal models, including zebrafish and killifish.
Imaging of Humans
Advanced PET Imaging Facility (UAB)
The Facility houses the most innovative, cutting-edge PET imaging equipment and expands UAB’s capability for clinical and experimental PET. The Facility has two time-of-flight GE Discovery 710 PET CT scanners and plans to add at least two more. The core of the Facility is the 61,000-lb. cyclotron, the most powerful at any academic medical center in the United States. UAB’s TR24 cyclotron is a type of particle accelerator that moves protons along a spiral path to strike a target.
Functional Neuroimaging Laboratory (UAB)
The Laboratory houses a 3T head-only Siemens Magnetom Allegra Magnetic Resonance Imaging and Spectroscopy scanner, optimized for neuroimaging applications. This scanner is a dedicated system for examination of the human brain, making it uniquely suited to psychiatric imaging applications. The magnet is a lightweight (4t) and short-bore (1.25m) actively-shielded superconducting magnet with external interference shielding and provides excellent homogeneity by extended passive shimming methods.
MRI Research Center (7Tesla, Auburn)
The Auburn MRI Research Center seeks to leverage existing expertise in engineering, sciences and veterinary medicine to improve healthcare through advanced magnetic resonance imaging. It features a Siemens Verio open-bore 3T MRI scanner for clinical and research use and one of the first actively-shielded whole-body 7T MRI scanners in the US for research use.
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The UAB CCTS is supported through the
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