The CFAR Network of Integrated Clinical Systems (CNICS) research network is the first electronic medical records-based resource network poised to integrate clinical data from the large and diverse population of HIV-infected persons in the modern HAART era.  CNICS was funded in 2006 as an R24 award to provide a research infrastructure to support HIV clinical outcomes and comparative effectiveness research using data collected from patients receiving care at one of 8 US-funded Center for AIDS Research (CFAR) sites. As of mid 2014, CNICS contained 29,797 patients; 81% male and 19% female. To download the most recent cohort demographics table, click here. CNICS directly reflects the outcomes of clinical decisions and management options made daily in the care of HIV infected individuals. Unlike data collected in structured interviews or retrospective medical record review, CNICS captures a broader range of information associated with the rapidly changing course of HIV disease management. The flexibility of this consortium enables CNICS to address scientific questions that cannot be answered through other collaborative cohorts. The greatest distinction between CNICS and other cohorts is its ability to provide peer-reviewed-open access to a rich and rapidly evolving clinical platform for research that prospectively collects comprehensive patient data including validated outcomes, longitudinal resistance data, and detailed PROs with readily available biological specimens.  By actively encouraging the use of CNICS data by other investigators, there is enormous potential for significant contributions to emerging clinical, translational, and social-behavioral research over the next decade as the HIV epidemic continues to grow.

Would you like to see if there are enough patients in the cohort that qualify for a particular study? Investigators should submit the Study Feasibility Form to inquire. You will receive aggregate data that will let you know if sufficient numbers of patients qualify for your study. No actual clinical data will be transmitted.

Are you interested in specimens only? If so, submit a Specimen Feasibility Request. CNICS will work with you to optimize your specimen request and determine availability. Shipping and handling costs associated with specimen requests are the responsibility of the requesting investigator. Specimens are not stored at a central repository but maintained at each site. Costs associated with specimen shipments from multiple sites may be incurred, depending on the study.

Acknowledging CNICS
Support the CNICS mission by acknowledging the network in publications, abstracts, grant proposals and presentations.  Wording suggestions include:

This research was supported by the CFAR Network of Integrated Clinical Systems-CNICS, an NIH funded program (R24 AI067039) that was made possible by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Heart, Lung and Blood Institute (NHLBI). The CFAR sites involved in CNICS include: University of Washington (P30 AI027757), University of Alabama at Birmingham (P30 AI027767), University of California at San Diego (P30 AI036214), University of California at San Francisco (P30 AI027763), Case Western Reserve University (P30 AI036219), Johns Hopkins University (P30 AI094189), Fenway Clinic of Harvard University (P30 AI060354), and University of North Carolina Chapel Hill (P30 AI50410).

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