The mission of CNICS is to provide access to the specimen and data repository to any investigator who submits an approved concept proposal. In this fashion, CNICS is a 'peer-reviewed open access' research platform available to investigators world-wide. Currently, CNICS has the following approved concept studies ongoing.  Projects are identified by the approved study number, title, lead investigator and institution. Contact us for more information on any of these projects.

001:  Impact of HAART and Metabolic Complications on Myocardial Infarction and Survival among HIV-infected Patients / Heidi Crane UW

002:  Incidence and Risk Factors for Triple Class Antiretroviral Regimen (ARV) Exposure and Failure in the CNICS Cohort / Richard Haubrich UCSD

003:  Biological and behavioral correlates of ART adherence and depression across diverse patients in the CNICS cohorts / Steven Safren Fenway

004:  The incidence and correlates of HIV superinfection before starting and after stopping antiretroviral therapy / Davey Smith UCSD

009:  Predictors of Severe Liver Enzyme Elevation and Immunologic Response to Initial HAART in Patients with HIV and Hepatitis Co-Infection /     Chad Achenbach Northwestern

010:  Eligibility for Early Initiation of Highly Active Antiretroviral Therapy (HAART) to Decrease HIV Transmission / Julie Dombrowski UW

011:  Durability and Effectiveness of First-line ARV Regimens in treatment-naïve Patients Initiating Therapy in a Clinical Practice Setting / Michael Mugavero UAB

012:  Association of cellular immune function and phenotype with severe liver enzyme elevation (LEE) after Highly Active Antiretroviral Therapy (HAART) among HIV and viral hepatitis co-infected patients / Chad Achenbach Northwestern

013:  Long-term virologic outcomes of HIV-infected patients coinfected with hepatitis B on tenofovir-containing HAART / Nina Kim UW

014:  Prevalence and associations of unprotected sex and substance use in the CNICS cohort / Matthew Mimiaga Fenway

015:  Dynamic Assessment of Virologic Response and Mortality Among HIV-infected Patients Initiating Antiretroviral Therapy / Michael Mugavero UAB

016:  An Analysis of Renal Function Before and After the Initiation of Highly Antiretroviral Therapy (HAART) to Examine Correlates of Renal Function Preservation and Decline / Robert Kalayjian CWRU

017:  HIV Pathogenesis and Immunity in Viremic Non-Progressors / David Camerini UC Irvine

018:  The Predictors of HIV+ smokers and investigation of smoking recognition and intervention by providers in two HIV ambulatory clinics / Karen Cropsey UAB

019:  Molecular Epidemiology of HIV Transmission and Transmitted Resistance in Women and Minorities in the CNICS Cohort / Jeannette Aldous UCSD

020:  HIV infection in Sickle Cell Disease / Michael Lederman CWRU

022:  Comparison of plasma HIV RNA with CD4+ T cell count-based strategies for detection of first line treatment failure and initiation of regimen modification / Maya Peterson UC Berkeley

023:  Measuring HIV transmission risk among HIV+ patients at CNICS sites / Joseph Schumacher UAB

024:  AIDS-defining and non-AIDS defining malignancies  among the CFAR Network of Integrated Clinical Systems (CNICS) / Michael Saag UAB

025:  Effects of Hepatitis B co-infection on HIV Antiretroviral Therapy Response and Long-term Outcomes / Sarah Radke UNC

027:   Methods to migrate from the 9-item Patient Health Questionnaire (PHQ-9) to computerized adaptive administration of the Patient Reported Outcomes Measurement Information System (PROMIS) depression measure / Heidi Crane UW

028:   HIV Infection and Response to Initial Therapy for Type 2 Diabetes / Jennifer Han UPENN

029:   Contribution of enzyme (protease) and substrate (gag) mutations to protease inhibitor resistance / David Looney UCSD

030:   Epidemiology & Outcomes of HIV-2 in the United States / Geoffrey Gottlieb UW

031:   Adherence to Clinical Care and Survival among HIV-infected Patients Initiating Antiretroviral Therapy / Michael Mugavero UAB

032:   HIV in the Elderly: Evaluating Indoleamine 2,3 dioxygenase as a marker for disease status / Stephanie Baer Medical College of GA

033:   HIV-associated Obstructive Pulmonary Disease Examinations (HOPE): Risk, Exacerbations, and Outcomes / Kristina Crothers UW

034:   Prognosis of incidence and progression risk of AIDS-defining and non-AIDS-defining malignancies in HIV/AIDS patients / Julia Krauchanka Duke

035:   Body morphology abnormalities and patient reported outcomes:  depression, adherence, health-related quality of life, substance use, physical activity, and sexual risk behavior / Heidi Crane UW

036:   Routine Laboratory Monitoring During Virologically Suppressive Combination Antiretroviral Therapy in the US / Babafemi Taiwo Northwestern

037:   Fine mapping of MHC susceptibility loci for AIDS-related non-Hodgkin lymphoma / Brahim Aissani UAB

038:   The Timing of Antiretroviral Initiation among ART Naïve HIV Infected patients in routine clinical practice / Elvin Geng UCSF

039:   Cross-walk between commonly used measures of anxiety in patients with HIV and the Patient Reported Outcomes Measurement Information System (PROMIS) anxiety measure / Heidi Crane UW

040:   Determinants of Transmitted Drug Resistance (TDR) and Impact of “Test and Treat” Strategy on Transmission of Drug Resistance Among HIV-1 Infected Treatment-Naïve Patients: Influence of High Risk Behaviors as Determined by Patient Based Metrics (PBM) on TDR Prevalence and Modeled Probability of Transmission / Vi Bowman UCSD

041:   Systematic Characterization of High-Risk HPV Infection in Head and Neck Carcinoma in HIV+ Individuals / Margaret Brandwein-Gensler UAB

042:   Durability of initial compared to subsequent HAART regimens / Eric Sahloff  U of Toledo

043:   Comparing Results from Two Methods for Estimating the Optimal CD4 Threshold for Initiating Antiretroviral Therapy / Bryan Shepherd Vanderbilt

044:   Biological Determinants of Long-term Immune Reconstitution following Combination Antiretroviral Therapy (cART) / Sharon Lewin Monash Univ-Australia

045:   BMI, Depression, and HIV Self-Care Behaviors among MSM /  Aaron Blashill Fenway

046:   Impact of presenting clinical features and subsequent treatment on outcomes after non-CNS HIV-associated lymphoma in the CNICS cohort / Satish Gopal UNC

047:  Time related factors of platelet count reduction in human immunodeficiency virus/HIV and Hepatitis C/HCV co-infected antiretroviral therapy/ARV Naiive patients / Chris Delaney Univ of FL

048:   Structural models for exposure effects in HIV progression cohorts / Steve Cole UNC

049:   Effects of Combination Antiretroviral Therapy on Risk of Non-AIDS-defining Cancers / Elizabeth Yanik UNC

050:  The Causal Effect of Antidepressant Treatment on HIV Outcomes in the CNICS Multi-Site Observational Clinical Cohort: an Application of Marginal Structural Models / Brian Pence Duke

051: Risk factors and microRNA profiles of HIV associated lung cancer / Kristina Crothers & Lynn Schnapp   UW

052: Molecular epidemiology of HIV transmission networks between Rhode Island and Massachusetts / Phillip Chan  Brown Univ

053: Incidence and treatment of prostate cancer in HIV-infected men: do racial disparities exist? / Ramona Bhatia  Northwestern

055: Current practice of screening for incident HCV infection among HIV-infected individuals / Benjamin Linas   Boston Medical Center

056:  Evaluating the relationship between HIV transmission networks in the San Diego-Tijuana cross-Border HIV epidemic and the rest of the United States and the difference between geographically localized and geographically diverse transmission networks / Sanjay Mehta  UCSD

057: The Natural History of Malignancies Developing Among HIV Positive Individuals on Stable Antiretroviral Therapy / Anna Coghill  UW

058: Endothelial dysfunction, antiretroviral therapy, and non-AIDS defining events in the CNICS cohort / Susan Graham UW

059: When to switch cART: A comparison of switching strategies using observational data / Lauren Cain  Harvard

060: Effects of Hepatitis C Co-Infection in HIV Disease Progression and Long Term Outcomes / Jennifer Ling  UW

061: Frailty in HIV-Infected Older Adults / Charles Kamen and Supriya Mohile  U Rochester

062: STI Screening and determinants of infection among HIV-infected patients in primary care / Kenneth Mayer  Fenway

063: Diagnosis and treatment of depression in HIV/AIDS primary care: a comparative analysis of latino and non-latino white patients / Oscar Beltran  UTEP

067: Molecular profiling of HIV-associated lymphoma occurring before and during antiretroviral therapy / Satish Gopal  UNC

068: Alcohol Research Consortium in HIV – Epidemiological Research Arm (ARCH-ERA) U01AA020793 / Heidi Crane UW

071: Factors that influence the response to Hepatitis A vaccine among HIV-infected individuals / Heidi Crane UW