The types of research supported spans nearly all areas of HIV investigation. CNICS has focused on many of the emerging questions of high significance in the modern treatment era of the HIV epidemic, including: (i) pathogenesis of HIV infection, focusing on the biological factors that contribute to non-AIDS and AIDS morbidity in the context of long-term ART; (ii) the epidemiology of HIV disease in a diverse and representative group of patients; (iii) the comparative effectiveness of different therapeutic strategies; (iv) the impact of treatment on depression, body morphology, symptoms, and other PRO measures; and, (v) the factors associated with linkage and retention in care. The following publications are a result of studies conducted using the CNICS cohort. Contact us for more information on any of these studies.

2012

Integrating a web-based patient assessment into primary care for HIV-infected adults.

Fredericksen, RJ, Crane, et al.,. Journal of AIDS and HIV Research. 2012, 4(2): 47-55

Early retention in HIV care and viral load suppression: implications for a test and treat approach to HIV prevention.

Kozak M, Mugavero MJ, Ye J, Aban I, Lawrence S, Nevin CR, Raper JL, McCullumsmith C, Schumacher JE, Crane HM, Kitahata MM, Saag MS, Willig JH.   Clin Infect Dis 2011 Clin Infect Dis. 2012 Jan;54(1):141-7. PMCID: PMC3243652

2011

Viremia Copy-Years Predicts Mortality Among Treatment-Naive HIV-Infected Patients Initiating Antiretroviral Therapy.

Mugavero MJ, Napravnik S, Cole SR, Eron JJ, Lau B, Crane HM, Kitahata MM, Willig JH, Moore RD, Deeks SG, Saag MS; on behalf of the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) Cohort Study. Clin Infect Dis. 2011 Nov;53(9):927-935. PMCID: PMC3189165

The Effect of AIDS Clinical Trials Group Protocol 5164 on the Time From Pneumocystis jirovecii Pneumonia Diagnosis to Antiretroviral Initiation in Routine Clinical Practice: A Case Study of Diffusion, Dissemination, and Implementation.

Geng EH, Kahn JS, Chang OC, Hare CB, Christopoulos KA, Jones D, Petersen ML, Deeks SG, Havlir DV, Gandhi M. Clin Infect Dis. 2011 Nov;53(10):1008-14. PMCID: PMC3193829

Mortality among antiretroviral-eligible patients in an urban public clinic.

Transmitted Drug Resistance in the CFAR Network of Integrated Clinical Systems Cohort: Prevalence and Effects on Pre-Therapy CD4 and Viral Load.

Age at cancer diagnosis among persons with AIDS.

Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.

SenGupta D, Tandon R, Vieira RG, Ndhlovu LC, Lown-Hecht R, Ormsby CE, Loh L, Jones RB, Garrison KE, Martin JN, York VA, Spotts G, Reyes-Terán G, Ostrowski MA, Hecht FM, Deeks SG, Nixon DF.J Virol. 2011 Jul;85(14):6977-85.PMCID: PMC3126607

The Role of Toxicity-Related Regimen Changes in the Development of Antiretroviral Resistance.

Comparative Effectiveness and Toxicity of Statins Among HIV-Infected Patients.

Singh S, Willig JH, Mugavero MJ, Crane PK, Harrington RD, Knopp RH, Kosel BW, Saag MS, Kitahata MM, Crane HM.Clin Infect Dis. 2011 Feb 1;52(3):387-95. PMCID: PMC3106249

HIV infection, inflammation, immunosenescence, and aging.

Impact of NRTIs on lipid levels among a large HIV-infected cohort initiating antiretroviral therapy in clinical care.

2010

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Van der Laan, M and Peterson, M. Case study: Analysis of longitudinal HIV cohort data to improve management of antiretroviral treatment failure. Accepted book chapter in Targeted Learning from Data: Estimation for Causal Inference. (eds. Van der Laan and Rose). Springer Series in Statistics.

Mathews WC, Cachay ER, Caperna J, Sitapati A, Cosman B, et al. 2010 Estimating the Accuracy of Anal Cytology in the Presence of an Imperfect Reference Standard. PLoS ONE 5(8): e12284.  

Bedimo R, Westfall A, Mugavero M, Drechsler H, Khana N, Saag M. Hepatitis C Co-Infection and the Risk of Cardiovascular Disease Among HIV-Infected Patients HIV Medicine 2010 Aug;11(7):462-8. 

Cachay, ER, Caperna J, Sitapati, AM, Jafari, H, Kandel, S, Mathews C. Utility of clinical assessment, imaging, and cryptococcal antigen titer to predict AIDS-related complicated forms of cryptococcal meningitis. AIDS Research and Therapy 2010;7:29.

Crane PK, Gibbons LE, Willig JH, Mugavero MJ, Lawrence ST, Schumacher JE, Saag MS, Kitahata MM, Crane HM. Measuring depression and depressive symptoms in HIV-infected patients as part of routine clinical care using the 9-item patient health questionnaire (PHQ-9) AIDS Care Jul 2010;22(7):874-885. 

Kempf MC, McLeod J, Boehme AK, Walcott MK, Wright L, Seal P, Norton WE, Mugavero M, Moneyham L. A Qualitative Study of the Barriers and Facilitators to Retention-in-Care among HIV-positive Women in the Rural Southeastern U.S.: Implications for Targeted Interventions AIDS Patient Care STDS. 2010 Jul 30 Epub

Pence BW, Raper JL, Reif S, Thielman NM, Leserman J, Mugavero MJ.  Incident Stressful and Traumatic Life Events and HIV Sexual Transmission Risk Behaviors in a Longitudinal, Multisite Cohort. Psychosom Med 2010 Jul 1 Epub.

Reif S, Mugavero M, Raper J, Thielman N, Leserman J, Pence B. Highly Stressed: Stressful and Traumatic Experiences among Individuals with HIV/AIDS in the Deep South AIDS Care 2011 Feb;23(2):152-62.

Moneyham L, McLeod J, Boehme A, Wright L, Mugavero M, Seal P, Norton WE, Kempf MC. Perceived Barriers to Care among HIV+ Women in the Deep South J Assoc Nurses AIDS Care 2010 Epub.

Cole SR, Napravnik S, Mugavero MJ, Lau B, Eron JJ, Saag MS. Copy-years Viremia as a Measure of Cumulative HIV Viral Burden Am J Epidemiology 2010;171:198-205 PMCID: PMC2878100.

Willig JH, Echevarria J, Westfall AO, Iglesias D, Henostroza G, Seas C, Mugavero MJ, Allison J, Paz J, Hernandez F, Tomatis C, Saag MS, Gotuzzo E.  Durability of initial antiretroviral therapy in a resource constrained setting and the potential need for zidovudine weight-based dosing. J Acquir Immune Defic Syndr 2010;53:215-21.

Mimiaga, M. J., S. L. Reisner, H. Goldhammer, A. M. Tetu, C. Belanoff and K. H. Mayer 2010. "Sources of human immunodeficiency virus and sexually transmitted disease information and responses to prevention messages among Massachusetts men who have sex with men." Am J Health Promot 24(3): 170-7.

Gill MJ, May M, Lewden C, Saag M, Mugavero M, Reiss P, Ledergerber B, Mocroft A, Harris R, Fux CA, Justice A, Costagliola D, Casabona J, Hogg RS, Khaykin P, Lampe F, Vehreschild J, Sterne JAC. Causes of Death in HIV-1 Infected Patients Treated with Antiretroviral Therapy 1996-2006: Collaborative Analysis of 13 HIV Cohort Studies Clin Infect Dis 2010;50:1387-96.

Lawrence, ST, Willig, JH, Crane, HM, Ye, J, Aban, I, Lober, W, Nevin, C, Batey, DS, Mugavero, M, McCullumsmith, C, Wright, C, Kitahata, M, Raper, JL, Saag, & MS, Schumacher, J.  Routine self-administered, touch-screen computer based suicidal ideation assessment linked to automated response team notification in an HIV primary care setting.  Clinical Infectious Diseases, 2010 Apr 15;50(8):1165-73. PMCID: PMC2841210.

Safren, S. A., L. Traeger, M. R. Skeer, C. O'Cleirigh, C. S. Meade, C. Covahey and K. H. Mayer 2010. "Testing a social-cognitive model of HIV transmission risk behaviors in HIV-infected MSM with and without depression." Health Psychol 29(2): 215-21. PMC2841316.

2009

O'Cleirigh, C., M. Skeer, K. H. Mayer and S. A. Safren 2009. "Functional impairment and health care utilization among HIV-infected men who have sex with men: the relationship with depression and post-traumatic stress." J Behav Med 32(5): 466-77.

Szumowski, J. D., K. M. Wener, H. S. Gold, M. Wong, L. Venkataraman, C. A. Runde, D. E. Cohen, K. H. Mayer and S. B. Wright (2009). "Methicillin-resistant Staphylococcus aureus colonization, behavioral risk factors, and skin and soft-tissue infection at an ambulatory clinic serving a large population of HIV-infected men who have sex with men." Clin Infect Dis 49(1): 118-21.

Taylor, L. E. and K. H. Mayer (2009). "Acute hepatitis C virus infection in an HIV clinic and in community settings." Gastroenterology 136(7): 2411-2.

Johnson, C. V., M. J. Mimiaga, S. L. Reisner, A. M. Tetu, K. Cranston, T. Bertrand, D. S. Novak and K. H. Mayer 2009. "Health care access and sexually transmitted infection screening frequency among at-risk Massachusetts men who have sex with men." Am J Public Health 99 Suppl 1: S187-92.

Mayer, K. H., C. O'Cleirigh, M. Skeer, C. Covahey, E. Leidolf, R. Vanderwarker and S. A. Safren 2009. "Which HIV-infected men who have sex with men in care are engaging in risky sex and acquiring sexually transmitted infections: findings from a Boston community health centre." Sex Transm Infect 86(1): 66-70.

Mimiaga, M. J., D. J. Helms, S. L. Reisner, C. Grasso, T. Bertrand, D. J. Mosure, H. Weinstock, C. McLean and K. H. Mayer 2009. "Gonococcal, chlamydia, and syphilis infection positivity among MSM attending a large primary care clinic, Boston, 2003 to 2004." Sex Transm Dis 36(8): 507-11.

McKinnell JA, Lin HY, Nevin CN, Willig JH, McFarland G, Genz M, Raper JL, DeLaitsch LL, Mrus JM, Klaskala W, Mugavero MJ, Saag MS Early Virologic Suppression with Three-Class Experienced Patients: 24-week Effectiveness in the Darunavir Outcomes Study AIDS 2009: 23(12):1539-46.

When to Start Consortium. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies Lancet 2009;373:1352-63.

Antiretroviral Therapy Cohort Collaboration. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal Clin Infect Dis 2009;48:1138-1151

Kelley CF, Kitchen CMR, Hunt PW, Rodriguez B, Hecht FM, Kitahata M, Crane HM, Willig J, Mugavero M, Saag M, Martin JN, Deeks SG. Incomplete Peripheral CD4+ Cell Count Restoration in HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment Clin Infect Dis 2009;48:787-794 PMCID: PMC2720023.

Antiretroviral Therapy Cohort Collaboration. Prognosis of patients treated with cART from 36 months after initiation, according to current and previous CD4 cell count and plasma HIV-1 RNA measurements AIDS 2009;23:2199-2208.

Deeks SG, Gange SJ, Kitahata MM, Saag MS, Justice AC, Hogg RS, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Benson CA, Collier AC, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Kushel MB, Goedert JJ, McKaig RG, Moore RD. Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America Clin Infect Dis 2009;49:1582-90 PMCID: PMC2871149.

Antiretroviral Therapy Cohort Collaboration. Effect of baseline CD4 cell counts on the clinical significance of short-term immunologic response to antiretroviral therapy in individuals with virologic suppression. J Acquir Immune Defic Syndr 2009;52:357-63.

Mugavero MJ, Raper JL, Reif S, Whetten K, Leserman J, Thielman NM, Pence BW. Overload: The Impact of Incident Stressful Events on Antiretroviral Medication Adherence and Virologic Failure in a Longitudinal, Multi-site HIV Cohort Study Psychosom Med 2009;70:921-6.

Antiretroviral Therapy Cohort Collaboration. Mortality of HIV-infected patients starting potent antiretroviral therapy: comparison with the general population in nine industrialized countries. Int J Epidemiol 2009;38:1624-33.

Mugavero MJ, Lin HY, Willig JW, Westfall AO, Ulett KB, Routman JS, Abroms S, Raper JL, Saag MS, Allison JJ. Missed Visits and Mortality in Patients Establishing Initial Outpatient HIV Treatment Clin Infect Dis 2009;48:248-56 PMCID: PMC2737584.

Mugavero MJ, Lin HY, Allison JJ, Giordano TP, Willig JW, Raper JL, Wray NP, Cole SR, Schumacher JE, Davies S, Saag MS. Racial Disparities in HIV Virologic Failure: Do Missed Visits Matter? J Acquir Immune Defic Syndr 2009;50:100-108 PMCID: PMC2766510.

Ulett KB, Willig JH, Lin HY, Routman JS, Abroms S, Allison J, Chatham A, Raper JL, Saag MS, Mugavero MJ.The Therapeutic Implications of Timely Linkage and Early Retention in HIV Care. AIDS Patient Care STDS 2009;23:41-1-49. PMCID: PMC2733237.

Crane, HM, Grunfeld, C, Harrington, RD, & MM Kitahata. Lipoatrophy and lipohypertrophy are independently associated with hypertension. HIV Medicine: 2009:10(8):496-503. PMCID: PMC2729358

2008

Kitahata MM, Rodriguez B, Haubrich R, Boswell S, Mathews WC, Lederman MM, Lober WB, Rompaey SE, Crane HM, Moore RD, Bertram M, Kahn JO, Saag MS. Cohort profile: the Centers for AIDS Research Network of Integrated Clinical Systems. Int J Epidemiol. 2008; 37(5): 948-55. PMCID: PMC2597168

Robison LS, Westfall AO, Mugavero MJ, Kempf MC, Cole SR, Allison JJ, Willig JH, Raper JL, Wilcox CM, Saag MS. Short-term Discontinuation of HAART Regimens More Common in Vulnerable Patient Populations AIDS Res Hum Retroviruses 2008;24:1347-1355.

Willig JH, Abroms S, Westfall AO, Routman J, Adusumilli S, Varshney M, Allison J, Chatham A, Raper JL, Kaslow RA, Saag MS, Mugavero MJ.   Increased regimen durability in the era of once daily fixed-dose combination antiretroviral therapy AIDS 2008;22:1951-60 PMCID: PMC2828871.

Tan R, Westfall AO, Willig JH, Mugavero MJ, Saag MS, Kaslow RA, Kempf MC. Clinical Outcome of HIV-Infected Antiretroviral-naïve Patients with Discordant Immunologic and Virologic Responses to Highly Active Antiretroviral Therapy J Acquir Immune Defic Syndr 2008;47:553-58

Willig JH, Jackson DA, Westfall AO, Allison JJ, Chang PW, Raper JL, Saag MS, Mugavero MJ. Clinical Inertia in the Management of LDL Abnormalities in an HIV Clinic Clin Infect Dis 2008;46:1315-18

Jiang W, Lederman MM, Mohner RJ, Rodriguez B, Nedrich TM, Harding CV, Sieg SF. Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection. J Virol 82 (16): 7837-45, 2008.

Sieg SF, Bazdar DA, Lederman MM. S-phase entry leads to cell death in circulating T cells from HIV-infected persons. J Leukoc Biol 83 (6): 1382-7, 2008.

Crane, HM, Grunfeld, C, Harrington, RD, Ciechanowski, PS, & MM Kitahata. Lipoatrophy among HIV-infected patients is associated with higher levels of depression than lipohypertrophy. HIV Med. 2008 Oct;9(9):780-6. PMCID: PMC2698046.

2007

Bagchi S, Kempf MC, Westfall AO, Maherya A, Willig J, Saag MS. Can Routine Clinical Markers be used Longitudinally to Monitor Antiretroviral Therapy Success in Resource-Limited Settings? Clin Infect Dis 2007;44(1):135-138.

Chen RY, et al. Complete Blood Cell Count as a Surrogate CD4 Cell Marker for HIV Monitoring in Resource-Limited Settings. J Acquir Immune Defic Syndr 2007;44(5):525-30.

Matthews C, Caperna J, Cachay ER, Cosman B. Early Impact and Performance Characteristics of an Established Anal Dysplasia Screening Program : Program Evaluation Considerations The Open AIDS Journal 2007 1 :11-20.

Crane, HM, Lober, W, Webster, E, Harrington, RD, Crane, PK, Davis, TE, & MM Kitahata. Routine collection of patient-reported outcomes in an HIV clinic setting: the first 100 patients. Current HIV Research, 2007, 5(1): 109-18.

Dion ML, Bordi R, Zeidan J, Asaad R, Boulassel MR, Routy JP, Lederman MM, Sekaly RP, Cheynier R. Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection. Blood 109 (7): 2912-20, 2007

Luciano AA, Lederman MM, Valentin-Torres A, Bazdar DA, Sieg SF. Impaired Induction of CD27 and CD28 Predicts Naive CD4 T Cell Proliferation Defects in HIV Disease. J Immunol 179 (6): 3543-9, 2007.

Rodriguez B, Valdez H, Mijch A, Watson K, Lederman MM, McComsey GA, Loupa CV, Woolley I. Statins Blunt HAART-Induced CD4 T-Cell Gains but Have No Long-Term Effect on Virologic Response to HAART. J Int Assoc Physicians AIDS Care (Chic Ill), 2007.

Yonkers NL, Rodriguez B, Milkovich KA, Asaad R, Lederman MM, Heeger PS, Anthony DD. TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection. J Immunol 178 (7): 4436-44, 2007.