WelcomeThe University of Alabama (UA) Board of Trustees in their meeting on February 3, 2006 has approved the formation of "Center for Nanoscale Materials and Biointegration (CNMB)". This new center at University of Alabama at Birmingham (UAB) is housed in the Department of Physics with participation of faculty from the College of Arts and Sciences, School of Business, School of Dentistry, School of Engineering, and School of Medicine.
UAB envisions the creation of a world-class interdisciplinary research and student training center focusing on the synthesis and characterization of nanoscale materials and structures with applicability and integration into the biomedical arena that will position the Center to be at the forefront of nanotechnologies and biomaterials for human health.
Congratulations to Sonal Singh and co-authors for their recently accepted manuscript. The paper entitled ”Spatially Controlled Fabrication of Brightly Fluorescent Nanodiamond-Array with Enhanced Far-Red Si-V Luminescence" (by Sonal Singh, Vinoy Thomas, Dmitri Martyshkin, Veronika Kozlovskaya, Eugenia Kharlampieva, and Shane Catledge) will appear in the Journal Nanotechnology. The paper will be available online to readers at http://iopscience.org/. This work demonstrates a novel approach to precisely pattern fluorescent nanodiamond-arrays with enhanced far-red intense photostable luminescence from silicon-vacancy (Si-V) defect centers. The precision-patterned pre-growth seeding of nanodiamonds is achieved by a scanning probe “Dip-Pen” nanolithography technique using electrostatically-driven transfer of nanodiamonds from “inked” cantilevers. The enhanced emission from nanodiamond-dots in the far-red is achieved by incorporating Si-V defect centers in subsequent chemical vapor deposition treatment. The authors anticipate that the far-red intense photostable luminescence (~738 nm) observed from Si-V defect centers integrated in spatially arranged nanodiamonds could be beneficial for the development of the next generation fluorescent based devices and applications.
CNMB Member Dr. Claudiu T Lungu Awarded a National Institute for Occupational Safety & Health Grant (CDC/DHHS R21, Total amount for two years: 09/01/2013 – 08/31/2015: $398,672)
The goal of this study is to develop a new technique that allows accurate sampling of gases and vapors at low levels.
Dr. Lungu is investigating a new process of using pulsed visible light to release chemicals from new substrates based on carbon nanotubes. These substrates will be used in air sampling devices for volatile organic compounds and gases for workplace or environmental monitoring. This research could potential lead to a new generation of air samplers that may be faster, cheaper, and more sensitive than the currently available models.
CNMB Member Dr. Eugenia Kharlampieva Awarded a National Science Foundation Biomaterials Grant
Immunomodulatory Ultrathin Multilayer Coatings for Pancreatic islet Transplantation NSF-DMR1306110, program of Biomaterials (BMAT)
This grant will supports the development of a novel type of cytoprotective material with controlled immunomodulatory and inflammatory responses to be used for cell-based transplantation therapy for diabetic recipients. This project is in collaboration between departments of Chemistry (Eugenia Kharlampieva, PI) and Microbiology (Hubert Tse, coPI). Although transplantation of pancreatic islet cells has emerged as a promising treatment for Type 1 diabetes, its clinical application remains limited due to adverse effects of immunosuppression and declining allograft function. The awarded project will develop a preclinical approach to preserve islet viability and function during culturing and transplantation by protecting pancreatic islets (cell clusters) with a novel polymer coating. These coatings will be designed through hydrogen-bonded assembly of cytocompatible macromolecules with antioxidant and anti-inflammatory characteristics. This project is particularly timely since current islet encapsulation systems are challenging for transplantations due to high cytotoxicity and the requirement for large injection volumes. The design of novel immunoprotective materials will open new prospects for developing biomaterials with unique characteristics having applications in various bio-related areas such as bioengineering and tissue engineering. The awarded project will develop interdisciplinary collaborative research which should stimulate awareness of the needs of the UAB biomedical research community for specialized polymer-based biomaterials as novel platforms for cell transplantation therapy.
CNMB Researchers Build Nanoscale Future – Small World
National Institutes of Health Issues a Small Business Technology Transfer Phase II Award to Vista Engineering and UAB CNMB Scientists
National Institute of Dental and Craniofacial Research (NIDCR) has issued a two-year commercialization award entitled “Nanotechnology Enabled Temporomandibular Joint (TMJ) Prosthesis” to a Birmingham based company Vista Engineering and UAB CNMB researchers (Vista PI Dr. Raymond Thompson and UAB PI Dr. Yogesh Vohra, Dr. Aaron Catledge, and Dr. Patrick Louis). This award of $746,369 is for a two-year period starting August 15th, 2011. It is estimated that over 10 million people in the United States experience pain and dysfunction in and near the TMJ. Typical symptoms include facial and jaw joint pain, neck and shoulder pain, headaches, locking of the jaw, and limited opening or inability to open the mouth comfortably. The vast majority of these patients can be treated with conservative, non-invasive therapies. However, some patients with severe TMJ degeneration may require a prosthetic replacement. Implants have been used primarily to replace the articular disc of the joint and the condylar head of the mandible. However, long-term success and functioning of these implants remains a serious problem. Major factors contributing to the failure of TMJ devices include the choice of the design and materials of the implant, and the production of wear particles that can trigger a cascade of events that ultimately may result in the damage to TMJ structures. CNMB scientists and Vista engineering have been exploring the use of nanostructured diamond coatings on metallic components of TMJ to lower mechanical wear and improve clinical outcomes. The goal of this STTR Phase II program is to design a minimally invasive diamond-on-diamond articulating TMJ device using computational modeling approaches. This next generation of TMJ device will be fabricated and tested in a TMJ wear-simulator to have a service lifetime of more than ten-years of clinical use. The TMJ devices that show lowest mechanical wear in simulator studies will also be tested in an animal model. The clinical translational studies are planned to eventually allow testing of new TMJ devices for human use in the next few years.