Welcome to the CSB!
The Center for Structural BiologyMission
The Center for Structural Biology includes a multidisciplinary group of researchers all focused on the structure/function relationships for biomolecules involved in fundamental processes, the elucidation of mechanisms behind infectious and chronic diseases and the pursuit of structural information to support the development of novel pharmaceuticals.
The CSB is responsible for the coordination of a number of structural biology-related activities across the UAB campus including: 1) sponsorship of Invited Speaker Seminar Series addressing a broad range of exciting structural biology topics, 2) sponsorship of a monthly Student Colloquium where graduate and post-graduate students present their research projects and an open discussion between faculty and students regarding program changes or improvements, desired new courses in structual biology, suggestions for external invited speakers, 3) provide Pilot Funding to UAB faculty members to support new or existing structural biology-related research projects, 4) support Recruitment of Structural Biology Faculty in various UAB departments, 5) support Maintenance of UAB's Structural Biology Facilities (i.e. x-ray crystallography, electron microscopy, surface plasmon resonance, calorimetry, etc.), 6) provide UAB investigators and regional scientists Access to UAB's Premiere Facilities.
Major facilities/capabilities include Protein Crystallization, BioCalorimetry, X-ray Crystallography, High-field NMR Spectroscopy, Mass Spectrometry, Analytical Ultracentrifugation and Computational Modeling. Details for each facility are provided via the Services and and Facilites link at the top of this page.
A common theme of the structural biology faculty members is recognition of the central importance of obtaining and utilizing structural information to understand biological function at the molecular level. Systems under study include proteins involved in immune response, ion and metabolite transport, cell-cell recognition, multi-drug-resistance, virus-host interactions, signal transduction, protein folding, protein-nucleic acid interactions and more. Current drug development programs focus on cancer, infectious diseases, parkinson's disease, cystic fibrosis, cardiovascular disease, bacterial infections, diabetes and immune response. The CSB has extensive expertise in structure determination of both aqueous and membrane proteins, large macromolecular complexes and whole viruses. Detailed descriptions of individual research projects can be found by clicking on the faculty link at the top of this page.