Welcome to the CSB!

The Center for Structural Biology is a University Wide Interdisciplinary Research Center

Mission

The Center for Structural Biology (CSB) is a university-wide center responsible for coordination of a number of structural biology-related activities across the UAB campus  including: 1) sponsorship of Invited Speaker Seminar Series addressing a broad range of exciting structural biology topics, 2) sponsorship of a monthly Student Colloquium where graduate and post-graduate students present their research projects and an open discussion between faculty and students regarding program changes or improvements, desired new courses in structual biology, suggestions for external invited speakers, 3) provide Pilot Funding to UAB faculty members to support new or existing structural biology-related research projects, 4) support Recruitment of Structural Biology Faculty in various UAB departments, 5) support Maintenance of UAB's Structural Biology Facilities (i.e. x-ray crystallography, electron microscopy, surface plasmon resonance, calorimetry, etc.), 6) provide UAB investigators and regional scientists Access to UAB's Premiere Facilities.  

Facility Description

Major facilities/capabilities include X-ray Crystallography, High-field NMR Spectroscopy, Cryo-electron Microscopy, Mass Spectrometry, Analytical Ultracentrifugation and Computational Modeling. Details for each facility are provided via the Services and and Facilites link at the top of this page.

Research Information

A common theme of the structural biology faculty members is recognition of the central importance of obtaining and utilizing structural information to understand biological function at the molecular level. Systems under study include proteins involved in immune response, ion and metabolite transport, cell-cell recognition, multi-drug-resistance, virus-host interactions, signal transduction, protein folding, protein-nucleic acid interactions and more. Current drug development programs focus on cancer, infectious diseases, parkinson's disease, cystic fibrosis, cardiovascular disease, bacterial infections, diabetes and immune response.  The CSB has extensive expertise in structure determination of both aqueous and membrane proteins, large macromolecular complexes and whole viruses. Detailed descriptions of individual research projects can be found by clicking on the faculty week at the top of this page.