Kurt R. Zinn, D.V.M., Ph.D.

Professor of Radiology, Electrical and Computer Engineering

DVM, University of Missouri College of Veterinary Medicine
PhD, Biochemistry, University of Missouri

Websites:
http://medicine.uab.edu/radiology/67760/


Dr. Zinn earned his B.A. in Chemistry from the University of Missouri. Remaining at the University of Missouri, he went on to earn a Masters in Chemistry and a D.V.M, followed by a Ph.D. in Biochemistry. In 1995, he relocated to UAB, rising to Professor in the Departments of Medicine, Radiology and Pathology in 2003. Dr. Zinn has received numerous awards for his scientific accomplishments, including the Benadict Cassen Imaging Award (twice) and the Southern Societies Young Faculty Award. He holds an array of patents pertaining to the generation of diagnostic radioisotopes.


Research Interests

Dr. Zinn’s research focus is the development of novel imaging techniques for the screening and precise location of tumors and metastases.  He also has lead efforts to develop reporter systems for the imaging of gene transfer and apoptosis in vivo.  In addition, his laboratory has pioneered non-invasive small animal imaging for the study of biological, infectious and immunological events in vivo.


Recent Publications

Zinn KR, Anderson CA, Bradbury M, Cutler CS, Peterson TE, Morgan DE, Price JC, Graham MM, Contag CH, Wittstrom K, Norenberg JP Components of a Curriculum for Molecular Imaging Scientists. J Nucl Med 52(4): 50-6, 2011.
Kim H, Folks KD, Guo L, Sellers JC, Fineberg NS, Stockard CR, Grizzle WE, Buchsbaum DJ, Morgan DE, George JF, Zinn KR. Early Therapy Evaluation of Combined Cetuximab and Irinotecan in Orthotopic Pancreatic Tumor Xenografts by Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Molecular Imaging 10:153-167, 2011.
Zinn KR, Chaudhuri TR, Szafran AA, O'Quinn D, Weaver C, Dugger K, Lamar D, Kesterson RA, Wang X, Frank SJ. Noninvasive bioluminescence imaging in small animals. ILAR J 49 (1): 103-15, 2008.
Borovjagin AV, McNally LR, Wang M, Curiel DT, MacDougall MJ, and Zinn KR, Noninvasive Monitoring of mRFP1- and mCherry-Labeled Oncolytic Adenoviruses in an Orthotopic Breast Cancer Model by Spectral Imaging. Molecular Imaging 9: 59-75, 2010.
Hoyt K, Warram J, Umphrey H, Belt L, Lockhart M, Robbin M, Zinn, KR. Determination of breast cancer response to antiangiogenic therapy in a murine model using contrast-enhanced ultrasound and artificial neural networks. Journal of Ultrasound in Medicine, 29, 575-583, 2010.
Kim H, Folks KD, Guo L, Stockard CR, Fineberg N, Grizzle WE, George JF, Bachsbaum DJ, Morgan DE, Zinn KR. DCE-MRI Detects Early Vascular Response in Breast Tumor Xenografts Following Anti-DR5 Therapy, Mol Imaging Biol 13(1):94-103, 2011.
Kim H, Chen J, Zinn KR, Hubbard WJ, Fineberg NS, Chaudry IH. Single photon emission computed tomography demonstrated efficacy of 17beta-estadiol therapy in male rats after trauma-hemorrhage and extended hypotension, J Trauma 69(5):1266-73, 2010.
Beck BH, Kim HG, Kim H, Samuel S, Liu Z, Shrestha R, Haines H, Zinn K, Lopez RD. Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. Breast Cancer Res Treat, 122(1):135-144, 2010.
Warram J, Borovjagin A, Zinn KR. A genetic strategy for combined screening and localized imaging of breast cancer, Molecular Imaging & Biology
Helman EE, Newman JR, Dean NR, Zhang W, Zinn KR, Rosenthal EL. Optical imaging predicts tumor response to anti-EGFR therapy, Cancer Biol Ther 10(2):166-71, 2010.
Chacko BK, Reily C, Srivastava A, Johnson MS, Ulasova E, Agarwal A, Zinn K, Murphy MP, Kalyanaraman B, Darley-Usmar V Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy Mito Q., Biochem 432(1):9-19, 2010.
Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Kappes JC, Zinn KR, Prasain JK, Carroll SL. Tamoxifen Inhibits Malignant Peripheral Nerve Sheath Tumorigenesis via an Estrogen Receptor-Independent Mechanism, Neuro Oncol 1:28-41, 2011.