Berry, Joel, Ph.D
Research Associate Professor
1825 University Blvd. Birmingham, AL 35294-2182
PhD, Biomedical Engineering, Wake Forest University, 2001
MS, Mechanical Engineering, University of Alabama at Birmingham (UAB), 1992
BS, Mechanical Engineering, University of Alabama at Birmingham (UAB), 1989
BS, Biology, University of Alabama at Birmingham (UAB), 1985
BME 350 - Biological Transport Phenomena
BME 313- Bioinstrumentation
Dr. Berry’s major interests lie in two areas: cardiovascular biomechanics and tissue engineering. His research has focused largely on modeling the fluid and solid mechanical effects of metallic stents placed into normal and diseased arteries. His group has published more than 10 papers on this subject and received 4 patents for metallic stent designs as well created a startup company around 2 of the patents. In addition to theoretical and experimental in vitro modeling of stents, he has designed and conducted several pre-clinical studies in swine and primate peripheral arteries, the outcome of which have demonstrated that the stent structure has a profound influence on the arterial response. It is from this base of knowledge and experience that his research has led to the concept of perfused, cell-seeded, prevascularized scaffolds for the purpose of overcoming oxygen diffusion limitations in engineered tissues. Dr. Berry has developed a technique for prevascularizing scaffold materials with 250 micron channels and shown that these channels also support a layer of endothelial cells under pulsatile flow conditions. This work is aimed at resolving some important limitations that currently exist 2D in vitro and in vivo animal studies that are current paradigm in anti-cancer drug development.
RECENT PUBLICATIONS (2011-2013)
Andukuri A., Kushwaha1 M., Tambralli A, B.S., Anderson J., Dean D.R., Berry J.L., Young D.S., Yoon Y.S., Brigitta B.C., Jun H.W.. A hybridbiomimetic nanomatrix composed of electrospun polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants. Acta Biomaterialia 7;225–233, 2011.
Baker S., Sigley J., Helms C.C., Stitzel J., Berry J., Bonin K., Guthold M.. The mechanical properties of dry, electrospun fibrinogen fibers. Materials Science and Engineering C 32; 215–221, 2012.
Fee T.J., Dean D.R., Eberhardt A.E., Berry, J.L. A Novel Device to Quantify the Mechanical Properties of Electrospun Nanofibers. J Biomech Eng. 134(10), 2012.
Sorace A.G., Robbin M.L., Umphrey H., Abts C.A., Berry J.L., Lockhart M.E., Allon M., Hoyt K.. Ultrasound Measurement of Brachial Artery Elasticity Prior to Hemodialysis Access Placement- A Pilot Study. J Ultrasound Med. 31(10):1581-8, 2012.
Kuppler C.S., Christie J.W., Newton W.B. 3rd, Ghanami R.J., Craven T.E., Berry J..L, Hansen K.J.J Surg Res. 183(1):457-61, 2013.
Goldstein A.S., Bashur C.A., Berry J. Chapter 15, Strategies to Engineer Electrospun Scaffold Architecture and Function. The Handbook of Intelligent Scaffold for Regenerative Medicine. Ed. Gilson Khang, Pan Stanford, Singapore, 2009.
Berry J.L., Rojas A., Sano M., Davalos R., Johnson K., O´Rourke L., and Gatenholm P. BNC-biomaterials with controlled architecture for tissue engineering scaffolds and customizable implants. Taylor and Francis (2012).
RESEARCH FUNDING (2012-2013)
Development of a Hybrid Dynamic Stent (2012) - National Institutes of Health SBIR, $150,000.
The fibrotic matrix fiber topology and myofibroblast differentiation (2013) – UAB Biomatrix Engineering and Regenerative Medicine Center, $45,000
Microvascularized 3D Breast Cancer Constructs for Drug Testing and Development (2012) –Department of Defense (DoD) office of the Congressionally Directed Medical Research Programs (CDMRP), $533,112.
Berry J.L., Newman V.S., Ferrario C.M., Dean R.H.: “Expandable Intraluminal Stents,” Patent number 5,702,419.
Berry J.L., Newman V.S., Ferrario C.M., Dean R.H.: “Expandable Intraluminal Stents,” Patent number 6,248,128,131.
Berry J.L., Moore, J.E.: “Compliant Intraluminal Stents,” Patent number 6,206,910,131.
Berry J.L., Moore, J.E.: “Compliant Intraluminal Stents,” Patent number 6,572,649.
Berry J.L., Reynolds J.E., Branch C.L.: “Surgical Head Support Adapter,” Patent number D603967.
American Society of Mechanical Engineers
Biomedical Engineering Society