Song, Yuhua, Ph.D.
- Associate Professor
Shelby Biomedical Research Bldg
1825 University Blvd
- (205) 996-6939
- (205) 975-4919
ACADEMIC BACKGROUND Postdoc training, Computational Biology, Washington University in St. Louis, 2002-2005 Postdoc training, Computational Biomechanics, University of Pittsburgh, 2001-2002 Postdoc training, Computational Materials Science & Engineering, Tsinghua University, 1998-2001 PhD, Materials Science & Engineering, Harbin Institute of Technology, 1998 MS, Materials Science & Engineering, Harbin University of Science and Technology, 1996 BS, Materials Science & Engineering, Jilin University of Technology, 1989 TEACHING BME 333-Biomechanics of Solid BME 480:580-Biomolecular Modeling RESEARCH We use the combined computational and experimental methods, biophysics, biochemistry and biomechanics multidisciplinary approaches to investigate the calmodulin and Fas mediated cancer pathogenesis and develop cancer chemotherapic agents. We also investigate the regulation mechanisms for glycosylated integrin-mediated signaling in cell adhesion, and thrombospondin and calreticulin modulated signaling in cell adhesion disassembly. Designing collagen-mimic biomaterials and understanding the regulation mechanisms of the novel biomaterials with biomembrane are also group interests. Methodology development for multiscale modeling to integrate the atomic-detailed molecular dynamics simulation and continuum finite element method to study the complex biological systems is another focus of the group. RECENT PUBLICATIONS (2008-2010) Di Pan, Yuhua Song. Role of Altered Sialylation of the I-like Domain of β1 Integrin in the Binding of Fibronectin to β1 Integrin: Thermodynamics and Conformational Analyses. Biophys. J. 2010, 99(1) (In press)
Qi Yan, Joanne E. Murphy-Ullrich, Yuhua Song. Structural Insight for the Role of Thrombospondin-1 Binding to Calreticulin in Calreticulin-Induced Focal Adhesion Disassembly. Biochemistry, 2010, 49 (17), pp 3685–3694
Yawar J. Qadri, Yuhua Song, Catherine M. Fuller and Dale J. Benos. Amiloride Docking to Acid-sensing Ion Channel-1. J Biol Chem. 2010 Mar 26;285(13):9627-35. Epub 2010 Jan 4.
Yawar J. Qadri, Bakhrom K. Berdiev, Yuhua Song, Howard L. Lippton, Catherine M. Fuller, and Dale J. Benos. Psalmotoxin-1 docking to human acid sensing ion channel-1. Journal of Biological Chemistry, 284(26), 17625-17633, 2009
Anthony N. Vomund, Sarah Stuhlsatz-Krouper, Yuhua Songand William A. Frazier. Breaking an Extracellular α-β Clasp Activates β3 Integrins. Biochemistry, 2008, 47 (44): 11616-11624
Jonathan Suever, Yabing Chen, Jay M McDonald, Yuhua Song*. Conformation and Free Energy Analyses of the Complex of Ca2+-Bound Calmodulin and the Fas Death Domain. Biophys. J. 2008; 95(12): 5913–5921
Yuemin Liu, Di Pan, Susan L. Bellis, Yuhua Song. Effect of Altered Glycosylation on the Structure of the I-like Domain of beta1 Integrin: A Molecular Dynamics Study. Proteins: Structure, Function, and Bioinformatic, 2008; 73(4): 989-1000
Sun Joo Lee, Yuhua Song, Nathan A. Baker. Molecular dynamics simulations of asymmetric NaCl and KCl solutions separated by phosphatidylcholine bilayers: potential drops and structural changes induced by strong Na+-lipid interactions and finite size effects. Biophys. J. 2008;94 3565-3576
RESEARCH FUNDING (2008-2010) Protein interactions underlying Fas-mediated DISC in Cholangiocarcinoma, Principal Investigator, NIH/NCI, 08/14/2009 – 06/30/2014 SERVICE (current) Professional Service
Editorial Boards: MCB: Molecular & Cellular Biomechanics Manuscript Reviewer Biophysical Journal, Journal of Biomechanics, Biomechanics and Modeling in Mechanobiology, Polymer Engineering and Science, Materials & Design University committees: Graduate Program Committee, Department of Biomedical Engineering, UAB Department Strategy plans Committee, Department of Biomedical Engineering, UAB Computer and Networking Advisory Committee, School of Engineering, UAB Equity and Diversity Committee, School of Engineering, UAB Committee for mentoring women in Information and Technology, UAB Community Service Outreach activities with UAB CORD program