Jere Segrest, M.D., Ph.D.
Professor, Department of Medicine
RESEARCH DESCRIPTIONLipid exchange and particle remodeling are critically important processes during metabolism of high density lipoprotein (HDL) particles at every step in the antiatherogenic process of reverse cholesterol transport. Because HDL is a soft form of condensed matter easily deformable by thermal fluctuations, the mechanisms for HDL dynamics and remodeling are not well understood. We are using a computational approach—molecular dynamics (MD) simulations and molecular modeling—to aid in exploring the dynamic structure of both discoidal and spheroidal (circulating) HDL and the mechanisms of HDL particle assembly. Dr. Segrest has a broad background in Chemistry, Physics and Biochemistry, with specific training and experience in proteins, membranes and lipoproteins putting his lab in a unique position to address many of the important issues of HDL structure and function.