Noah_D Diana Noah, Ph.D.

Research Virologist, Viral Biochemistry
Division of Drug Discovery (Southern Research Institute)

Areas of Focus: Virus evasion of the cellular immune response and both viral and cellular factors involved in determining virus pathogenesis

Publications

Contact Information
Southern Research Institute
2000 9th Ave. S
Birmingham, AL 35205
(205) 581-2586
Email
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RESEARCH DESCRIPTION

     Dr. Noah is currently working in the Infectious Disease area to further the understanding of influenza virus pathogenesis, including the mechanisms utilized by the highly pathogenic avian influenza strains causing deaths throughout Asia. Influenza Virus is a member of the Orthomyxo virus family and causes a highly contagious respiratory disease that kills approximately 36,000 people in the United States annually. Worldwide epidemics cause many more deaths. The 1918 pandemic resulted in 20 to 40 million deaths worldwide. Current forecasters predict that antigenic shifts in the avian influenza viruses will cause outbreaks in Asia and result in the next pandemic. Dr. Noah's research focuses on the virus evasion of the cellular immune response and both viral and cellular factors involved in determining virus pathogenesis. Her lab utilizes reverse genetics to generate mutant recombinant influenza viruses which are then analyzed for increases and decreases in replication rate, cytokine production, and virulence in mice.

     The ultimate goal is to identify targets for the development of antiviral therapeutics.

BIOGRAPHY

     Dr. Diana Noah is a Research Virologist, Emerging Infectious Disease Research, Department of Biochemistry and Molecular Biology, at Southern Research Institute in Birmingham.  She received her B.S. degree from Ohio Sate University in Columbus, Ohio in 1992, and her Ph.D. degree from North Carolina State University in Raleigh, NC in 2000. Dr. Noah completed her postdoctoral studies at the University of Texas at Austin from 2000-2005.  She joined UAB as an Adjunct Assistant Professor in the Department of Biochemistry and Molecular Genetics in 2007.