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Heflin Center for Genomic Sciences Presents 

GENETICS AND GENOMICS IN CLINICAL RESEARCH

An Immersion Course for Clinical Investigators at UAB

August 20-24, 2012

8:00 AM – 12:00 Noon

Mon, Tues, Wed, and Fri. -- Rm. 302 Volker Hall
Thurs. -- Ireland Rom, 3rd floor Lister Hill Library 

Background

UAB investigators have access to a broad range of resources to help them incorporate genetics and genomics into their research. Although many investigators on campus are using genetics and genomics in their research, there are others who would benefit from an introduction or intensive review of the principles, major technologies, and experimental approaches in genetics and genomics. This immersion course is intended to provide that opportunity over a period of one week of morning lectures and workshops, with a goal of preparing investigators to quickly come up to speed in incorporating genetics and genomics in their research.

                blur      Developmental_Genomics     DNA_and_informatics_blue_background     Stylized_chromosomes     DNA_bases_3d

Learning Objectives

Upon completion of this course, participants should be able to establish collaborations with experts in genetics, genomics,and bioinformatics to accomplish the following:

1.     Design an approach to identify of a gene responsible for a phenotype in a family that segregates in a Mendelian manner.

2.     Devise an appropriately powered case-control or transmission disequilibrium study to identify single nucleotide polymorphisms in linkage disequilibrium with a multifactorial disorder.

3.     Develop a study comparing patterns of gene expression or methylation levels in normal vs. pathological tissue.

4.     Formulate a protocol involving human research subjects for a genetic or genomic study to be submitted for IRB review.

5.     Choose between alternative genotyping or next generation sequencing platforms appropriate for specific applications.

6.     Utilize major bioinformatic databases to analyze genomic data.

Approach

The course will take place over a one-week period from August 20-24, 2012, from 8 a.m. to noon each day.  Each day will consist of two hours of lecture followed by two hours of small group discussion, including case studies, laboratory demonstrations, problem solving, and use of bioinformatic databases. Exams will be given at the start and end of the course to help assess participant progress. 

Continuing Education

The University of Alabama School of Medicine designates this live activity for a maximum of 18.25 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Registration

The course is open to any UAB faculty member at any of the schools in the University. There is no charge for participation.  Registration is on a first-come first-served basis and will be limited to 30 participants.  Complete the online registration form or send the completed registration form below to  This email address is being protected from spambots. You need JavaScript enabled to view it. .

Course Schedule

  Monday

8/20/12

Tuesday

8/21/12

Wednesday

8/22/12

Thursday

8/23/12

Friday

8/24/12
8:00  - 8:50 Introduction
and
Pre-Test  

Genotyping
Technologies and
Copy Number
Variation Analysis 

Next-
Generation Sequencing

Genetic
Linkage Analysis 

 Approaches to
Bioinformatic Data
Analysis
9:00 - 9:50 Approaches
to Gene
Discovery

Analysis of Gene
Expression
and Methylation
Status

Whole Genome
Functional
Assays

Design and
Analysis of
Genetic
Association Studies

 Bioinformtic Pathway
and Ontology Analysis
10:00 - 12:00 Case Studies in
Translational Genomics		 Application of
Genotyping Platforms		 Functional Genomics Linkage Analysis,
PLINK Demo 		 Use of
Bioinformatic
Databases

Speakers

Dr. Molly Bray Dr. MIke Crowley Dr. Nianjun Liu Dr. Hemant Tiwari Jelai Wang
Dr. David Crossman Dr. Bruce Korf Dr. Fady Mikhail Dr. Howard Wiener

The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

The University of Alabama School of Medicine designates this live activity for a maximum of 18.25 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family‐friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of ethnicity, gender, faith, gender identity and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.

    


The CNR's UWIRC Series recently hosted Bruce Korf, MD, PhD who presented his talk titled "Genetics and Genomics in Clinical Research". Dr. Korf discussed the impact and value of using the science of genomics over a patient's lifespan - from newborn genetics screening to predispositional screening as a tool to provide comprehensive and competent healthcare.