Heflin Center for Genomic Sciences Presents 

GENETICS AND GENOMICS IN CLINICAL RESEARCH

An Immersion Course for Clinical Investigators at UAB

September 30 - October 4, 2013

8:00 AM – 12:00 Noon

Finley Conference Room 

Background

UAB investigators have access to a broad range of resources to help them incorporate genetics and genomics into their research. Although many investigators on campus are using genetics and genomics in their research, there are others who would benefit from an introduction or intensive review of the principles, major technologies, and experimental approaches in genetics and genomics. This immersion course is intended to provide that opportunity over a period of one week of morning lectures and workshops, with a goal of preparing investigators to quickly come up to speed in incorporating genetics and genomics in their research.

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Learning Objectives

Upon completion of this course, participants should be able to establish collaborations with experts in genetics, genomics,and bioinformatics to accomplish the following:

1.     Design an approach to identify of a gene responsible for a phenotype in a family that segregates in a Mendelian manner.

2.     Devise an appropriately powered case-control or transmission disequilibrium study to identify single nucleotide polymorphisms in linkage disequilibrium with a multifactorial disorder.

3.     Develop a study comparing patterns of gene expression or methylation levels in normal vs. pathological tissue.

4.     Formulate a protocol involving human research subjects for a genetic or genomic study to be submitted for IRB review.

5.     Choose between alternative genotyping or next generation sequencing platforms appropriate for specific applications.

6.     Utilize major bioinformatic databases to analyze genomic data.

Approach

The course will take place over a one-week period from August 20-24, 2012, from 8 a.m. to noon each day.  Each day will consist of two hours of lecture followed by two hours of small group discussion, including case studies, laboratory demonstrations, problem solving, and use of bioinformatic databases. Exams will be given at the start and end of the course to help assess participant progress. 

Continuing Education

The University of Alabama School of Medicine designates this live activity for a maximum of 18.25 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Registration

The course is open to any UAB faculty member at any of the schools in the University. There is no charge for participation.  Registration is on a first-come first-served basis and will be limited to 30 participants.  Please contact Michelle Amaral if interested in registering for this course.

Course Schedule

 

  Monday

9/30/13

Tuesday

10/1/13

Wednesday

10/2/13

Thursday

10/3/13

Friday

10/4/13

7:30 - 8:00

Breakfast

Breakfast

Breakfast

Breakfast

Breakfast

8:00  - 9:00

Introduction 

Genotyping
Technologies and
Copy Number
Variation Analysis 

Next-
Generation Sequencing

Approaches to
Bioinformatic Data
Analysis 

Genetic Linkage
Analysis

9:15 - 10:15

Approaches to
Gene Discovery

 

Microarray Based
Approaches for Gene
Expression and 
Methylation Status

Whole Genome
Functional
Assays

Bioinformatic
Pathway and
Ontology Analysis

Design and Analysis
of Genetic
Association Studies

10:30 - 11:30

Case Studies in
Translational Genomics

 

Analysis of
Microarray Data
Functional Genomics Use of 
Bioinformatic 
Databases
 

 

Speakers

Dr. Bruce Korf Dr. Mike Crowley Dr. David Crossman
Dr. Hemant Tiwari Dr. Fady Mikhail Dr. Michelle Amaral

 

The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

The University of Alabama School of Medicine designates this live activity for a maximum of 18.25 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family‐friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of ethnicity, gender, faith, gender identity and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.