The addition of a proteomics component to the Heflin Center reflects the opportunities for synergy in studies of genomics and proteomics. Proteomics technologies are advancing rapidly and are expanding our capabilities from the identification of single protein modifications to the discovery of novel diagnostics and disease-specific drug targets. UAB houses substantial proteomics instrumentation and expertise, including high-end technology-generated -omics resources outside of genomics. Several campus-wide collaborative and core laboratories are available to assist UAB researchers.
- UAB MS/Proteomics (MSP) Shared Facility, directed by Dr. James Mobley, greatly expands the capablilties of proteomic research with many cutting-edge technologies. The goal of the MSP Shared Facility is to provide state-of-the-art capabilities and training in mass spectrometry, proteomics, and bioanalytic technologies to support the research needs of UAB Cancer Center members.
- Targeted Metabolics & Proteomics Laboratories (TMPL) provides mass spectrometry-based analytical approaches to the study of biological samples, with a focus on quantitative assays for lipid, peptides, carbohydrates, and proteins. With 1D and 2D gels, the TMPL implements top-down proteomics discovery of differences among mictures of intact (non-digested) proteins using rifference "gel-free" liquid protien fractions separated electrophoretically. The TMPL is co-directed by Drs. Stephen Barnes and Helen Kim.
- The UAB Biomedical FI-ICR Mass Spectrometry Laboratory, led by Dr. Matt Renfrow, seeks to provide a unique research platform for the analysis of basic biomedical problems. The projects supported by the lab represent many areas of biomedical research. They all share the common theme of taking advantage of high resolution mass spectrometry and the versatility of these instruments to uniquely analyze and characterize biological systems.