After several decades of development, computer-aided engineering (CAE) is now a mature discipline playing an important role in design, analyses, and performance predictions. Computational technologies can benefit the biological and medical communities in understanding the dynamics and mechanics of human biological systems. However, the problem is how to represent complex, realistic 3D geometries which need to be reconstructed from medical images. The technical objectives of this task are to: a) develop a set of algorithms for automatic generation of quadrilateral and hexahedral elements; b) develop FE meshes of children aged 3, 6 and 10 years based on surface geometry provided by WSU; and c) assure mesh quality. UAB scientists have extensive experience in computational mesh generation for complex geometries such as human brains and skulls to undertake this task. Further, UAB has obtained an example skeletal system of an adult and used it as a platform for algorithm development and testing, while collaborators at WSU are obtaining the children’s geometry.