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Articular cartilage can undergo significant trauma-related changes in response to impact forces, such as those generated in motor vehicle crashes. The purpose of this study is three-fold: First, to shed light on the effects of trauma on articular cartilage immediately following impact. Second, to examine temporally - under explant culture conditions the effects of trauma on articular cartilage; and finally, to identify, describe and define the ameliorating effects of a bioactive agent on impacted articular cartilage.
To establish methodologies for protecting diarthrodial joints from injury following traumatic impact, this study is examining tolerance criteria of articular cartilage in joints in response to impact. Specifically, articular cartilage are being exposed to various impact intensities to identify detrimental biomechanical milieus and their temporal effects in cartilage pathophysiology.
In a later phase, the study will test an intervention strategy using a growth factor in an attempt to reverse the destructive effects of trauma.
