Recent and Selected Publications:

New, J.S., King, R.G., and Kearney, J.F.  Manipulation of the glycan-specific natural antibody repertoire for immunotherapy.  Immunological Reviews: 2016; 270(1): 32-50.  Abstract

Patel, P.S. and Kearney, J.F.  Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult life.  Journal of Immunology: 2015; 194(12): 5838-50.  Abstract

Wharton, R.E., Stefanov, E.K., King, R.G., and Kearney, J.F.  Antibodies generated against Streptococci protect in a mouse model of disemminated aspergillosis.  Journal of Immunology: 2015; 194(9): 4387-96.  Abstract

Honjo, K., Kubagawa, Y., Kearney, J.F., Kubagawa, H.  Unique ligand-binding property of the human IgM Fc receptor.  Journal of Immunology: 2015; 194(4):1975-82.  Abstract

Vale, A.M., Kearney, J.F., Nobrega, A., and Schroeder, H.W.  Molecular Biology of B cells. Second Edition.  Honjo, T., Reth, M., Radbruch, A., and Alt, F. editors.  New York: Elsevier; 2015.  Development and Function of B Cell Subsets.  p. 99-113.

Kearney, J.F., Patel, P., Stefanov, E.K., King, R.G.  Natural antibody repertoires: development and functional role in inhibiting allergic airway disease.  Annual Review of Immunology: 2015; 33:475-504.  Abstract

Vale, A.M., Kapoor, P., Skibinski, G.A., Elgavish, A., Mahmoud, T.I., Zemlin, C., Zemlin, M., Burrows, P.D., Nobrega, A., Kearney, J.F., Briles, D.E., Schroeder, H.W., Jr.  The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.  The Journal of Experimental Medicine: 2013; 210(5):875-90.  Abstract

Honjo, K., Kubagawa, Y., Jones, D.M., Dizon, B., Zhu, Z., Ohno, H., Izui, S., Kearney,J.F., and Kubagawa, H. Altered Ig levels and antibody reponses in mice deficient for the Fc receptor for IgM (FcuR).  Proceeedings of the National Academy of Sciences of the USA: 2012; 109(39):15882-7.  Abstract

Kin, N.W., Stefanov, E.K., Dizon, B.L.P., Kearney, J.F.  Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.  J Immunol: 2012 Sep 1; 189 (5), 2246-2256.  Abstract

Kearney, J.F. (2012), "Innate-like B cells", in Gordon, S. (ed.), Cells of the Innate Immune System: Roles in health and disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.  Online

Foote, J.B., Mahmoud, T.I., Vale, A.M., Kearney, J.F.  Long-term maintenance of polysaccharide-specific antibodies by IgM-secreting cells.  J Immunol: 2012 Jan 1; 188(1): 57-67. Epub 2011 Nov 23.  Abstract

Mahmoud, T.I., Schroeder, H.W., Jr., Kearney, J.F.  Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide alpha-1,3 dextran.  J Immunol: 2011 Jul 15; 187(2): 879-86.  Epub 2011 Jun 15.  Abstract

You, Y., Myers, R.C., Freeberg, L., Foote, J., Kearney, J.F., Justement, L.B., Carter, R.H.  Marginal zone B cells regulate antigen capture by marginal zone macrophages.  J Immunol: 2011 Feb 15;186(4):2172-81. Epub 2011 Jan 21.  Abstract

Foote, J.B., and Kearney, J.F. Generation of B Cell memory to the bacterial polysaccharide alpha 1-3 dextran. J Immunol: 183:6359-6368, 2009.  Abstract

Mahmoud, T.I., Kearney, J.F.
Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide alpha-1,3 dextran.  J Immunol: 2010 Jan 15;184(2):851-8. Epub 2009 Dec 16.  Abstract

Kin, N.W., Crawford, D.M., Liu, J., Behrens, T.W., and Kearney, J.F.  DNA Microarray  Gene Expression Profile of Marginal Zone versus Follicular B Cells and Idiotype     Positive Marginal Zone B Cells before and after Immunization with Streptococcus pneumoniae.  J. Immunol: 180:6663-74, 2008.  Abstract

Won W-Jai., Bachman, M.F., and Kearney, J.F.  Expression of CD36 by developing B cell subsets and during their responses to antigen., J.Immunol: 180, 230-237, 2008.  Abstract

Won, W-Jai., Foote, J.B., Odom, M., Pan, J., Kearney, J.F., and Davis , R.S.  FcHR3 is a novel immunoregulatory marker  of marginal zone and B1 B cells: J. Immunol. 177: 6815-23, 2006Abstract

Balazs, M., Martin, F., Zhou, T., and Kearney, J.F. Blood dendritic cells interact with splenic mariginal zone B cells to initiate T-independent immune responses. Immunity 17(3):341-52, Sep, 2002. Abstract

Martin, F. and Kearney, J.F. Marginal-zone B cells. Nature Reviews Immunology 2(5):323-35, May 2002. Abstract

Thai, T.H., Purugganan, M.M., Roth, D.B., and Kearney, J.F. Distinct and opposite diversifying activities of terminal transferase splice variants. Nat. Immunol. 3(5):457-62, May 2002. Abstract

Benedict, C.L., Gilfillan, S., and Kearney, J.F. The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoform. J. Exp. Med. 193:89-99, 2001. Abstract

Martin, F. and Kearney, J.F. B1 cells: Similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13:195-201, 2001. Abstract

Martin, F., Oliver, A.M., and Kearney, J.F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14:617-629, 2001. Abstract

Martin, F. and Kearney, J.F. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12(1):39-49, 2000. Abstract

Benedict, C.L. and Kearney, J.F. Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Immunity 10:607-617, 1999. Abstract


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