Recent Publications:

Kin, N.W., Stefanov, E.K., Dizon, B.L.P., Kearney, J.F.  Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.  J Immunol: 2012 Sep 1; 189 (5), 2246-2256.  Summary

Kearney, J.F. (2012), "Innate-like B cells", in Gordon, S. (ed.), Cells of the Innate Immune System: Roles in health and disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.  Online

Foote, J.B., Mahmoud, T.I., Vale, A.M., Kearney, J.F.  Long-term maintenance of polysaccharide-specific antibodies by IgM-secreting cells.  J Immunol: 2012 Jan 1; 188(1): 57-67. Epub 2011 Nov 23.  Summary

Kin, N.W., Chen, Y., Stefanov, E.K., Gallo, R.L., Kearney, J.F.  Cathelin-related antimicrobial peptide differentially regulates T- and B-cell function.  Eur J Immunol: 2011 Oct; 41(10): 3006-16.  Epub 2011 Aug 31.  Summary

Mahmoud, T.I., Schroeder, H.W., Jr., Kearney, J.F.  Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide alpha-1,3 dextran.  J Immunol: 2011 Jul 15; 187(2): 879-86.  Epub 2011 Jun 15.  Summary

You, Y., Myers, R.C., Freeberg, L., Foote, J., Kearney, J.F., Justement, L.B., Carter, R.H.  Marginal zone B cells regulate antigen capture by marginal zone macrophages.  J Immunol: 2011 Feb 15;186(4):2172-81. Epub 2011 Jan 21.  Summary

McPherson, S.A., Li, M., Kearney, J.F., Turnbough, C.L., Jr.  ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracis. Mol Microbiol: 2010 Jun;76(6):1527-38. Epub 2010 Apr 23.  Summary

Foote, J.B., and Kearney, J.F. Generation of B Cell memory to the bacterial polysaccharide alpha 1-3 dextran. J Immunol: 183:6359-6368, 2009.  Summary

Mahmoud, T.I., Kearney, J.F.
Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide alpha-1,3 dextran.  J Immunol: 2010 Jan 15;184(2):851-8. Epub 2009 Dec 16.  Summary

Oliva, C., Turnbough, C. L. , Jr., and Kearney, J. F. 2009. CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages. Proc Natl Acad Sci U S A: 106:13957-13962, 2009.  Summary

Kin, N.W., Crawford, D.M., Liu, J., Behrens, T.W., and Kearney, J.F.  DNA Microarray  Gene Expression Profile of Marginal Zone versus Follicular B Cells and Idiotype     Positive Marginal Zone B Cells before and after Immunization with Streptococcus pneumoniae.  J. Immunol: 180:6663-74, 2008. 
Summary

Lisanby, N., Swiecki M.K., Dizon, B., Pflughoeft. K., Koehler T., Kearney J.F. Cathelicidin administration protects mice from Bacillus anthracis spore challenge. J. Immunol: 181:4989-5000, 2008.  Summary

Oliva, C., Swiecki, M.
K, Griguer, C., Lisanby, M., Bullard, D., Turnbough, C.T., Jr., and Kearney, J.F. 
The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes., PNAS: 105:1261-1266, 2008. 
Summary

Won W-Jai., Bachman, M.F., and Kearney, J.F.  Expression of CD36 by developing B cell subsets and during their responses to antigen., J.Immunol: 180, 230-237, 2008. 
Summary

Steichen, C.T, Kearney,  J. F., and Turnbough, C.L. Jr.  Non-uniform assembly of the Bacillus anthracis exosporium and a bottle cap model for spore germination and outgrowth: Mol. Microbiol. 64:359-367, 2007. 
Summary

Berland, R., Fernandez, L., Kari, E., Han, J.H., Lomakin, I., Akira, S., Wortis, H.H., Kearney, J.F., Ucci, A.A., Imanishi-Kari, T.  Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity 25: 429-440, 2006. 
Summary

Boydston, J.A., Yue, L., Kearney, J.F., and Turnbough. C.T., Jr.  The ExsY protein is required for complete formation of the exosporium of Bacillus anthracis. J. Bacteriol.: 188: 7440-7448, 2006. 
Summary

Huang, H, Kearney, JF, Grusby MJ, Benoist, C., and Mathis, D.  Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc. Natl. Acad. Sci. USA 103:3734-3739, 2006.  Summary

Swiecki, MK, Lisanby, M.W, Turnbough, CL, Jr., and Kearney, JF.  Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowth. J. Immunol.:15;176: 6076-84, 2006. 
Summary

Won, W-Jai., Foote, J.B., Odom, M., Pan, J., Kearney, J.F., and Davis , R.S.  FcHR3 is a novel immunoregulatory marker  of marginal zone and B1 B cells: J. Immunol. 177: 6815-23, 2006Summary

Attanavanich, K. and Kearney, J. F.  Marginal zone but not follicular B cells are potent activators of na´ve CD4 T cells. J. Immunol. 172:803-811, 2004. Summary

Thai, To-Ha and Kearney, J. F.  Distinct and opposite activities of human terminal deoxynucleotidyl transferase splice variants. J. Immunol. 173:4009-4919, 2004. Summary

Balazs, M., Martin, F., Zhou, T., and Kearney, J.F. Blood dendritic cells interact with splenic mariginal zone B cells to initiate T-independent immune responses. Immunity 17(3):341-52, Sep, 2002. Summary

Martin, F. and Kearney, J.F. Marginal-zone B cells. Nature Reviews Immunology 2(5):323-35, May 2002. Summary

Thai, T.H., Purugganan, M.M., Roth, D.B., and Kearney, J.F. Distinct and opposite diversifying activities of terminal transferase splice variants. Nat. Immunol. 3(5):457-62, May 2002. Summary

Won, W.J. and Kearney, J.F. CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice. J. Immunol. 168(11):5605-11, Jun 1, 2002. Summary

Benedict, C.L., Gilfillan, S., and Kearney, J.F. The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoform. J. Exp. Med. 193:89-99, 2001. Summary

Martin, F. and Kearney, J.F. B1 cells: Similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13:195-201, 2001. Summary

Martin, F., Oliver, A.M., and Kearney, J.F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14:617-629, 2001. Summary

Martin, F. and Kearney, J.F. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12(1):39-49, 2000. Summary

Benedict, C.L. and Kearney, J.F. Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Immunity 10:607-617, 1999. Summary


 

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