Got Gout contact edited06052017

Gout (metabolic arthritis) is a disease created by a buildup of uric acid. Crystals of uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues.  These crystals cause inflammation and severe pain.  If not treated, the crystals form a tophi (Latin for stone), which can cause tissue damage.  Gout is caused by high concentrations of uric acid (hyperuricemia) combined with overall acidity in the bloodstream.  Separately, high levels of uric acid or acidity do not normally cause gout.

Gout most often occurs in men but it can affect women as well.  It most often attacks the big toe (about 75 % of first attacks) but it can also attack other joints such as the ankle, heel, instep, knee, wrist, elbow, fingers and spine. 

Symptoms

  • Excruciating, sudden unexpected burning pain
  • Swelling of affected joint
  • Redness of the affected joint
  • Warmth of the affected joint
  • Stiffness of the affected joint
  • Low-grade fever

Patients with long standing hyperuricemia may have uric acid crystal deposits in other areas such as the outer part of the ear.  High levels of uric acid in the urine can lead to uric acid kidney stones.


What Causes Gout?

Gout occurs when excess uric acid (a normal waste product) collects in the body, and needle‐like urate crystals deposit in the joints. This may happen because either uric acid production increases or, more often, the kidneys cannot remove uric acid from the body well enough. Certain foods and drugs may raise uric acid levels and lead to gout attacks. These include the following:

  • Foods such as shellfish and red meats
  • Alcohol in excess
  • Sugary drinks and foods that are high in fructose
  • Some medications


How is Gout Diagnosed?

Some other kinds of arthritis can mimic gout, so proper diagnosis (detection) is key. Health care providers suspect gout when a patient has joint swelling and intense pain in one or two joints at first, followed by pain‐free times between attacks. Early gout attacks often start at night. Diagnosis depends on finding the distinguishing crystals.


How Is Gout Treated?
With the use of Colchicine for acute flares. Other medications include non-steroidal anti-inflammatory drugs (NSAIDS) and corticosteroids.  It is important to contact your physician if you notice any of the symptoms above for best treatment.

Source: http://www.rheumatology.org/Practice/Clinical/Patients/Diseases_And_Conditions/Gout/


Gout Trials

Do you frequently have gout flares?

Are you currently experiencing a gout flare?
The purpose of this study is to evaluate how anakinra relieves pain for patients with acute gout that cannot take non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine. The patients will be divided in different treatment groups to compare anakinra to the available drug triamcinolone.
You may qualify for this study if you:

  • Are 18 years old or older
  • Have experienced no pain relief from, or are unable to take, medications commonly used to treat gout
  • Experience gout in four or fewer joints

Are you concerned about bone/joint damage due to gout?

Do you have chronic pain due to gout?
The purpose of this study is to determine safety and effectiveness of Denosumab in patients 30 years and older with erosive gout. It consist of 6 visits, and study medication and compensation for your time are provided by the study.
You may qualify for this study if you:

  • Age 30 or older
  • Have been diagnosed with gout
  • Are interested in taking an FDA-approved medication

Have you had trouble controlling your gout with medication?

Do you have chronic gout?
The main purpose of this research study is to see whether a new dosing regimen of KRYSTEXXA helps to improve gout symptoms, and reduces side effects due to KRYSTEXXA infusions.
You may qualify for this study if you:

  • Are 18 years old or older
  • Have been diagnosed with gout
  • Your gout symptoms are not well-controlled with medications typically used to treat gout

If you are interested in participating in one of our gout studies, please contact Stephanie at (205) 934-1444 or sbiggers@uabmc.edu

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