Dr. Judy R. Creigton is an assistant professor and a member of the research faculty in the UAB Department of Anesthesiology.

Dr. Creighton's research focuses on the discovery of endogenous repair mechanisms situated in the lung’s vascular lining, the endothelium.  Her current projects include: the function of Adenosine Monophosphate-activated Protein Kinase (AMPK) with respect to sub-cellular localization and tissue specific expression. Areas of interest related to this central theme include: metabolic mechanisms controlling endothelial permeability; endothelial cell-cell adhesion: cadherin expression and adherens junction composition; calcium channel regulation by vascular protective mechanisms; and endothelial phenotype specific response to stimuli.

Dr. Creighton can be reached at 205.934.7707 (office), 205.975.2757 (lab) or via email at This e-mail address is being protected from spambots. You need JavaScript enabled to view it .  To learn more about her lab, please visit her lab page.

Education and Degrees

• University of West Florida, Pensacola, FL, B.S., 1994
• University of South Alabama, Mobile, AL, Ph.D., 2006

Awards and Honors

• Outstanding Scholar, University of West Florida, 1994
• Member Phi Kappa Phi Honor Society, 1994

Professional Societies

• American Association for the Advancement of Science
• American Physiological Society
• Society for Experimental Biology and Medicine
• American Thoracic Society

 
Recent Publications

1.      Zhu B, Creighton J, and Stevens T. Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier Accepted: Am. J. Physiol Lung Cell Mol Physiol., 2010. 

2.      Creighton J, Zhu B, Alexyev M, and Stevens T. Spectrin-anchored phosphodiesterase  4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci. 121 (Pt 1):110-9, 2008.  

3.      Wu S, Cioffi E, Alvarez D, Sayner S, Chen H, Cioffi D, King J, Creighton J, Townsley M, Goodman S, and Stevens T. Essential role of a Ca²⁺ selective, store operated current (I_SOC) in endothelial cell permeability. Determinants of the vascular leak site. Circ Res. 96:856-863, 2005.

4.      King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, and Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc. Research, 67: 139-151, 2004.

5.      Creighton J, Masada N, Cooper DMF, and Stevens T. Coordinate regulation of membrane cAMP by Ca²⁺-inhibited adenylyl cyclase and phosphodiesterase activities. Am. J. Physiol Lung Cell Mol Physiol., 284 (1): L100-7, 2003.

6.      Cioffi DL, Moore TM, Schaack J, Creighton JR, Cooper DM, and Stevens T. Dominant regulation of interendothelial cell gap formation by calcium inhibited type 6 adenylyl cyclase. J. Cell Biol. 157 (7):1267-78, 2002

7.      Moore T, Norwood N, Creighton J, Babal P, Brough G, Shasby D, and Stevens T. Receptor dependent activation of store-operated Ca²⁺ entry increases endothelial cell permeability. Am. J. Physiol., 279: L691-L698, 2000.

8.      Norwood N, Moore T, Dean D, Bhattacharjee R, Creighton J, Babal P, and Stevens T. Store operated Ca²⁺ entry and endothelial cell permeability.  Am. J. Physiol Lung Cell Mol Physiol., 279: L815-L824, 2000.

9.      Stevens T, Creighton J, and Thompson, WJ. Control of cAMP in lung             endothelial cell phenotypes. Implications for control of barrier function.  Am. J.  Physiol., 277 (1 Pt 1), L119-26, 1999.