Dr. Creighton's research focuses on the discovery of endogenous repair mechanisms situated in the lung’s vascular lining, the endothelium. Her current projects include: the function of Adenosine Monophosphate-activated Protein Kinase (AMPK) with respect to sub-cellular localization and tissue specific expression. Areas of interest related to this central theme include: metabolic mechanisms controlling endothelial permeability; endothelial cell-cell adhesion: cadherin expression and adherens junction composition; calcium channel regulation by vascular protective mechanisms; and endothelial phenotype specific response to stimuli.
Dr. Creighton can be reached at 205.934.7707 (office), 205.975.2757 (lab) or via email at firstname.lastname@example.org. To learn more about her lab, please visit her lab page.
Education and Degrees
- University of West Florida, Pensacola, FL, B.S., 1994
- University of South Alabama, Mobile, AL, Ph.D., 2006
Awards and Honors
- Outstanding Scholar, University of West Florida, 1994
- Member Phi Kappa Phi Honor Society, 1994
- American Physiological Society, Respiration Section: New Investigator Award, 2011
- Star Reviewer, American Physiological Society, 2012
- American Association for the Advancement of Science
- American Physiological Society
- Society for Experimental Biology and Medicine
- American Thoracic Society
Jian M-Y, Alexeyev MF, Wolkowicz PE, Zmijewski JW and Creighton J. “Metformin stimulated AMPKα1 promotes microvascular repair in acute lung injury” AJP-Lung. 2013. Epub Oct 4. PMID:24097562.
Jiang S, Park DW, Stigler WS, Creighton J, Ravi S, Darley-Usmar V, Zmijewski, JW. “Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis” J Biol Chem. 2013 Sep 6;288(36):26013-26. Epub 21013 Jul 29. PMID:23897815.
Creighton J. Transmitting mechanical signals. Focus on "Mechanical induction of GroupV phospholipase A2 causes lung inflammation and acute lung injury" Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L279-81. E pub Jun 28. PMID:23812631.
Creighton J. Targeting therapeutic effects: sub-cellular location matters. Focus on “Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology” Am J Physiol Cell Physiol., Dec; 301(6): C1293-C1295. Epub Sep 28, 2011. PMID:21956167.
Creighton J, Jian MY, Sayner S, Alexeyev M, and Insel P. AMPK α1 promotes endothelial barrier repair. FASEBJ, Oct; 25(10):3356-65. Epub Jun 16, 2011. PMID: 21680893.
Zhu B, Creighton J, and Stevens T. Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier Accepted: Am. J. Physiol Lung Cell Mol Physiol., 2010.
Creighton J, Zhu B, Alexyev M, and Stevens T. Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci. 121 (Pt 1):110-9, 2008.
Wu S, Cioffi E, Alvarez D, Sayner S, Chen H, Cioffi D, King J, Creighton J, Townsley M, Goodman S, and Stevens T. Essential role of a Ca2+ selective, store operated current (ISOC) in endothelial cell permeability. Determinants of the vascular leak site. Circ Res. 96:856-863, 2005.
King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, and Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc. Research, 67: 139-151, 2004.
Creighton J, Masada N, Cooper DMF, and Stevens T. Coordinate regulation of membrane cAMP by Ca2+-inhibited adenylyl cyclase and phosphodiesterase activities. Am. J. Physiol Lung Cell Mol Physiol., 284 (1): L100-7, 2003.
Cioffi DL, Moore TM, Schaack J, Creighton JR, Cooper DM, and Stevens T. Dominant regulation of interendothelial cell gap formation by calcium inhibited type 6 adenylyl cyclase. J. Cell Biol. 157 (7):1267-78, 2002
Moore T, Norwood N, Creighton J, Babal P, Brough G, Shasby D, and Stevens T. Receptor dependent activation of store-operated Ca2+ entry increases endothelial cell permeability. Am. J. Physiol., 279: L691-L698, 2000.
Norwood N, Moore T, Dean D, Bhattacharjee R, Creighton J, Babal P, and Stevens T. Store operated Ca2+ entry and endothelial cell permeability. Am. J. Physiol Lung Cell Mol Physiol., 279: L815-L824, 2000.
Stevens T, Creighton J, and Thompson, WJ. Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function. Am. J. Physiol., 277 (1 Pt 1), L119-26, 1999.