Jean-Francois Pittet, MD
Professor, Vice Chair and Director
Division of Critical Care Anesthesiology

Dr. Pittet can be reached at 205.996.4755 or This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

Clinical Subspeciality and Area(s) of Interest

• Anesthesiology
• Critical Care
• Perioperative Medicine

Education and Degrees

• University of Lausanne, Lausanne, Switzerland, M.D., 1977
• Champittet College, Lausanne, Switzerland, B.A., 1970

Awards and Honors

• 3rd Award, Swiss Society of Surgery, 1989
• 2nd Award, 3rd International Steglitzer Symposium, 1989
• 1st Award, Swiss Society of Critical Care Medicine, 1990
• Elected to American Thoracic Society, 1994
• Elected to American Physiological Society, 1994
• Prospective Award, International Anesthesia Trauma and Critical Care Society, 1995

Professional Societies

• International Anesthesia Trauma and Critical Care Society
• American Society of Critical Care Medicine
• American Physiological Society
• International Anesthesia Trauma and Critical Care Society
• American Society of Critical Care Medicine
• American Physiological Society
• American Thoracic Society
• American Society of Anesthesiologists
• International Anesthesia Research Society
• European Society of Intensive Care Medicine
• California Thoracic Society
• European Surgical Infection Society
• California Society of Anesthesiologists
• Swiss Society of Anesthesologists
• Swiss Society of Critical Care Medicine
• Swiss Society of Enteral and Parenteral Nutrition

 Recent Publications

• Lee H, M Pespeni, J Roux, PA Dennery, MA Matthay, JF Pittet.  HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats.  FASEB J 19:287-9, 2005.
• Roux J, H Kawakatsu, B Gartland, M Pespeni, D Sheppard, MA Matthay, C Canessa, JT Pittet.  Interleukin-1beta decreases expression of the epithelial sodium channel alphs-ENaC in lung epithelial cells via a P38 MAP kinase-dependent mechanism. J Biol Chem 280:18579-89, 2005.
• Dehority W, K Lu, J Clements, J Goerke, JF Pittet, HW Taeusch.  Polyethylene glycol-surfactant for lavage lung injury in rats.  J Pediatr Res 58:913-8, 2005.
• Ganter MT, LB Ware, M Howard, MA Matthay, M Fleshner, JF Pittet.  Extracellular heat shock protein 72 in acute lung injury.  Am J Physiol Lung 291:L354-361, 2006.
• Godzich M,M Hodnett, JA Frank, G Su, M Pespeni, A Angel, MB Howard, MA Matthay, JF Pittet.  Activation of the stress protein response inhibits VEGF-dependent increase in vascular permeability in a model of lung ischemia-reperfusion injury in rats.  FASEB J 20:1519-21, 2006.
• Su G, M Hodnett, N Wu, A Atakilit, C Kosinski, M Godzich, XZ Huang, JA Frank, Ma Matthay, D Sheppard, JF Pittet.  Inegrin {alpha}v{beta}5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol 36:377-386, 2007.
• Pespeni M, M Hodnett, KS Abaysiriwardana, J Roux, M Howard, VC Broaddus, JF Pittet.  Sensitization of malignant cells to TRAIL-induced apoptosis by heat stress via the inhibition of the PDK-1/Akt pathway.  Cancer Res 67:2865-2871, 2007.
• Frank JA, JF Pittet, C Wray, MA Matthay.  Protection from experimental ventilator-induced lung injury by IL-1 receptor blockade. Thorax 63:147-153, 2008.
• Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, SU G, Sheppard D, Violette SM, Weinreb PH, HOran GS, Matthay MA, Pittet JF.  Interleukin-1beta causes acute lung injury via alphav-beta5 and alphavbeta6 integrin-dependent mechanisms.  Circ Res 102:804-812, 2008.
• *Song Y, *Pittet JF, Huang X, HE H, Lynch SV, Violette SM, Weinred PH, Horan GS, Carmago A, Sawa Y, Bernstein XL, Wiener-Kronish JP.  Infect Immun. 2008. June; 76(6):2325-32. Epub 2008. * These authors contributed equally to the work (co-first authors of the manuscript).
• Ganter MT, Roux J, G SU, SV Lynch, Frank JA, SU CS Deutschman, YG Weiss, S Christiaans, B Myasawa, E Kipnix, JP Wiener-Kronishm, MB Howard, JF Pittet.  Role of small GTPases and alphav-beta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothehelial permeability.  Am J Respir Cell Mol Biol (in press).