Judy R. Creighton, Ph.D.
Dr. Judy R. Creighton is an assistant professor and a member of the research faculty in the UAB Department of Anesthesiology.
Dr. Creighton's research focuses on the discovery of endogenous repair mechanisms situated in the lung’s vascular lining, the endothelium. Her current projects include: the function of Adenosine Monophosphate-activated Protein Kinase (AMPK) with respect to sub-cellular localization and tissue specific expression. Areas of interest related to this central theme include: metabolic mechanisms controlling endothelial permeability; endothelial cell-cell adhesion: cadherin expression and adherens junction composition; calcium channel regulation by vascular protective mechanisms; and endothelial phenotype specific response to stimuli.
Education and Degrees
- University of West Florida, Pensacola, FL, B.S., 1994
- University of South Alabama, Mobile, AL, Ph.D., 2006
Awards and Honors
- Outstanding Scholar, University of West Florida, 1994
- Member Phi Kappa Phi Honor Society, 1994
- American Physiological Society, Respiration Section: New Investigator Award, 2011
- Star Reviewer, American Physiological Society, 2012
- American Association for the Advancement of Science
- American Physiological Society
- Society for Experimental Biology and Medicine
- American Thoracic Society
Jian M-Y, Alexeyev MF, Wolkowicz PE, Zmijewski JW and Creighton J. “Metformin stimulated AMPKα1 promotes microvascular repair in acute lung injury” AJP-Lung. 2013. Epub Oct 4. PMID:24097562.
Jiang S, Park DW, Stigler WS, Creighton J, Ravi S, Darley-Usmar V, Zmijewski, JW. “Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis” J Biol Chem. 2013 Sep 6;288(36):26013-26. Epub 21013 Jul 29. PMID:23897815.
Creighton J. Transmitting mechanical signals. Focus on "Mechanical induction of GroupV phospholipase A2 causes lung inflammation and acute lung injury" Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L279-81. E pub Jun 28. PMID:23812631.
Creighton J. Targeting therapeutic effects: sub-cellular location matters. Focus on “Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology” Am J Physiol Cell Physiol., Dec; 301(6): C1293-C1295. Epub Sep 28, 2011. PMID:21956167.
Creighton J, Jian MY, Sayner S, Alexeyev M, and Insel P. AMPK α1 promotes endothelial barrier repair. FASEBJ, Oct; 25(10):3356-65. Epub Jun 16, 2011. PMID: 21680893.
Zhu B, Creighton J, and Stevens T. Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier Accepted: Am. J. Physiol Lung Cell Mol Physiol., 2010.
Creighton J, Zhu B, Alexyev M, and Stevens T. Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci. 121 (Pt 1):110-9, 2008.
Wu S, Cioffi E, Alvarez D, Sayner S, Chen H, Cioffi D, King J, Creighton J, Townsley M, Goodman S, and Stevens T. Essential role of a Ca2+ selective, store operated current (ISOC) in endothelial cell permeability. Determinants of the vascular leak site. Circ Res. 96:856-863, 2005.
King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, and Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc. Research, 67: 139-151, 2004.
Creighton J, Masada N, Cooper DMF, and Stevens T. Coordinate regulation of membrane cAMP by Ca2+-inhibited adenylyl cyclase and phosphodiesterase activities. Am. J. Physiol Lung Cell Mol Physiol., 284 (1): L100-7, 2003.
Cioffi DL, Moore TM, Schaack J, Creighton JR, Cooper DM, and Stevens T. Dominant regulation of interendothelial cell gap formation by calcium inhibited type 6 adenylyl cyclase. J. Cell Biol. 157 (7):1267-78, 2002
Moore T, Norwood N, Creighton J, Babal P, Brough G, Shasby D, and Stevens T. Receptor dependent activation of store-operated Ca2+ entry increases endothelial cell permeability. Am. J. Physiol., 279: L691-L698, 2000.
Norwood N, Moore T, Dean D, Bhattacharjee R, Creighton J, Babal P, and Stevens T. Store operated Ca2+ entry and endothelial cell permeability. Am. J. Physiol Lung Cell Mol Physiol., 279: L815-L824, 2000.
Stevens T, Creighton J, and Thompson, WJ. Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function. Am. J. Physiol., 277 (1 Pt 1), L119-26, 1999.