Dale Parks, Ph.D.

Professor and Director

dalep@uab.edu

205-934-1789

Clinical Subspecialty and Research Area(s) of Interest

·         Cardiovascular Disease

·         Hepatoenteric Ischemia-reperfusion

·         Multiple Organ Dysfunction  

Education and Degrees

·         University of South Alabama, Basic Medical Sciences (First 2 years medical school), 1981

·         University of South Alabama College of Medicine, Basic Medical Sciences and Physiology, Doctor of Philosophy, 1983

Awards and Honors

·         Society for Free Radical Research, Young Investigator Travel Award

·         Microcirculatory Society, Young Investigator Travel Award

·         Postdoctoral Fellowship, NIH Training Grant

·         Fellow of the Cardiovascular Section of the American Physiological

Society

·         Cardiovascular Council of American Heart Association

·         Fellow of the American Heart Association

·         Atherosclerosis, Thrombosis and Vascular Biology Council of the AHA

 Professional Societies

·         American Association for the Advancement of Science

·         American Association for Clinical Chemistry

·         American Gastroenterological Association

·         American Heart Association

·         American Physiological Society

·         American Society of Anesthesiologists

·         International Anesthesia Research Society

·         Microcirculatory Society

·         Research Society on Alcoholism

·         Society for Experimental Biology and Medicine

·         Splanchnic Circulation Group

·         The Oxygen Society

Recent Publications

·         Wallwork CJ, Parks DA, Schmid-Schönbein GW. Xanthine oxidase activity in the dexamethasone-induced hypertensive rat. Microvasc Res. 2003 Jul;66(1):30-7

·         Nielsen VG, Crow JP, Zhou F, Parks DA. Peroxynitrite inactivates tissue plasminogen activator. Anesth Analg. 2004 May;98(5):1312-7,

·         Nielsen VG, Crow JP, Mogal A, Zhou F, Parks DA. Peroxynitrite decreases hemostasis in human plasma in vitro. Anesth Analg. 2004 Jul;99(1):21-6

·         White CR, Parks DA, Patel RP, Shelton J, Tarpey MM, Freeman BA, Darley-Usmar VM. L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia. FEBS Lett. 2004 Mar 12;561(1-3):94-8

·         Chacko BK, Chandler RT, Mundhekar A, Khoo N, Pruitt HM, Kucik DF, Parks DA, Kevil CG, Barnes S, Patel RP. Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions.  Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H908-15.

·         Abou-Agag LH, Khoo NK, Binsack R, White CR, Darley-Usmar V, Grenett HE, Booyse FM, Digerness SB, Zhou F, Parks DA. Evidence of cardiovascular protection by moderate alcohol: role of nitric oxide. Free Radic Biol Med. 2005 Aug 15;39(4):540-8.

·         DeLano FA, Parks DA, Ruedi JM, Babior BM, Schmid-Schönbein GW.  Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation. 2006 Oct-Nov;13(7):551-66.

·          Parks DA, Binsack R, Crapo JD, Fridovich I, Wang Z, Batinic-Haberle I, Day BJ, Chumley PH and Freeman BA.  Manganese-porphyrin complexes are potent inhibitors of ischemia-induced liver injury, Free Radic Res.  41(2): 127-134, 2007.

·         Grenett HE, Abou-Agag LH, Tresnak JK, Parks DA, Benza RL, Booyse FM. Ethanol and red wine polyphenols induce the short-term downregulation of PAI-1 gene expression in vivo in rat thoracic aorta. J Sci Food Agric, 87: 1794-98, 2007.

·         Pasten C, Olave NC, Zhou L, Tabengwa EM, Wolkowicz PE, Grenett HE.  Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection.  Thromb Res. 2007;121(1):59-65.

·          Nielsen VG, Kirklin JK, Holman WL, Steewyk BL, George JF, Zhou F, Parks DA, Ellis TC.  Mechanical Circulatory Device Thrombosis:A New Paradigm Linking Hypercoagulation and Hypofibrinolysis. Am Soc Artific Int Org (ASAIO), in press, 2008.

·         Ulasova, E., Landar, A., Parks, D.A., Dell Italia, L. Ballinger. S., and Darley-Usmar, V.M. Oral Low Dose quercetin reverses concentric left ventricular hypertrophy in The Apo E knockout Mouse and Improves mitochondrial bioenergetics and protein repair.  Cardiovasc. Res., in review, 2008.

·         White CR, Constance C, Zhang C, Keaton A and Parks DA. Modulation of the Vasoconstrictor Response to Biogenic Amines by the Pro-Inflammatory Oxidant Hypochlorous Acid.  Free Radic. Res. In review, 2008.

·         Ellis TC, Nielsen VG, Kirklin JK, Holman WL, Steewyk BL, George JF, Zhou F, Parks DA, Burch TM.  Hypofibrinolytic disorders associated with heart failure and left ventricular assist device placement: a preliminary case series.  J Heart Lung Transplant, in review, 2008.

·         Skinner KA, Skinner HB, Thompson JA, Lebovitz R, Winokur T, Wang Z, Zhou F, Parks DA.  Hepatic ischemia and ethanol result in relocalization of cytosolic oxidases and coincident nitrotyrosine formation.  Prepared for submission to Am J Physiol.

·         Torres JA, Aikens ML, Abou-Agag LH, Grenett HE, Wheeler CG, White CR, Parks DA, Booyse FM. Cardioprotective benefits of red wine components: increased surface-localized fibrinolytic activity in cultured human endothelial cells.  Prepared for submission to Alcohol Clin Exp Res.

·         Iles K, Patel, M, Fisher W, Anantharamaiah GM, Agarwal A, White CR, Parks DA.  Vascular Dysfunction Resulting Hepatic Ischemia-Reperfusion is attenuated by an Apolipoprotein mimetic.  Prepared for Submission to Circulation, 2008.