Judy R. Creighton, Ph.D.
As a principal investigator, my research focuses on the discovery of endogenous repair mechanisms situated in the lung’s vascular lining, the endothelium. Although this thin layer of cells lines all vascular beds, not all endothelial cells are the same. Endothelium from various organs, and even from different vascular beds within the same organ, is physically and functionally distinct. I aim to understand how endothelium lining specific vascular segments within the lung contributes to overall lung health and to vascular repair following injury or disease.
Current projects include: the function of Adenosine Monophosphate-activated Protein Kinase (AMPK) with respect to sub-cellular localization and tissue specific expression. Areas of interest related to this central theme include: metabolic mechanisms controlling endothelial permeability; endothelial cell-cell adhesion: cadherin expression and adherens junction composition; calcium channel regulation by vascular protective mechanisms; and endothelial phenotype specific response to stimuli. The AMPK kinase project was recently funded by NIH through its R01 granting mechanism.
For additional information, please visit Dr. Creighton's faculty profile.
Ming Yuan Jian, M.D., Ph.D.
Instructor, UAB Department of Anesthesiology
Member, UAB Center for Lung Injury and Repair
Dr. Jian’s research focuses on mechanisms of vascular damage and repair in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). She has two current research interest areas. The first is to determine the function of adenosine monophosphate-activated protein kinase (AMPK) in the lung vasculature. She uses specific measures of endothelial permeability in isolated animal lungs and finds that AMPKα1 promotes endothelial barrier repair. Her second major research area involves an ongoing project, which explores the role of endostatin, an endogenous angiogenesis inhibitor, in molecular pathways that contribute to vascular damage and repair in ALI.
Dr. Jian received her doctoral degree of medicine (M.D.) and practiced as a physician of Anesthesiology at the teaching hospital of Hebei Medical University in Shijiazhuang, China. She obtained her Ph. D. at Shinshu University, Medical School in Japan and completed her postdoctoral fellowship at the University of South Alabama in Mobile.She is a member of the American Physiological Society and the American Thoracic Society. She serves as a reviewer for the American Journal of Respiratory Cell and Molecular Biology. She is regularly invited to present her work at international conferences such as Experimental Biology.