Publications

Jian M-Y, Alexeyev MF, Wolkowicz PE, Zmijewski JW and Creighton J.    “Metformin stimulated AMPKα1 promotes microvascular repair in acute lung injury” AJP-Lung. 2013. Epub Oct 4. PMID:24097562.

Jiang S, Park DW, Stigler WS, Creighton J, Ravi S, Darley-Usmar V, Zmijewski, JW. “Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis” J Biol Chem. 2013 Sep 6;288(36):26013-26. Epub 21013 Jul 29. PMID:23897815.

Creighton J. Transmitting mechanical signals. Focus on "Mechanical induction of GroupV phospholipase A2 causes lung inflammation and acute lung injury" Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L279-81. E pub Jun 28. PMID:23812631.

Creighton  J. Targeting therapeutic effects: sub-cellular location matters. Focus on “Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology.” Am J Physiol Cell Physiol., 2011 .Sep 28. [Epub ahead of print] PMID:21956167.

Creighton J, Jian MY, Sayner S, Alexeyev M, and Insel P.  Adenosine monophosphate –activated kinase α1 (AMPK α1) promotes endothelial barrier repair FASEBJ, Oct;25(10):3356-65. Epub Jun 16, 2011. PMID: 21680893.

Zhu B, Creighton J, and Stevens T. Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier Accepted: Am. J. Physiol Lung Cell Mol Physiol., 2010. PMID: 20639351.

Creighton J, Zhu B, Alexyev M, and Stevens T. Spectrin-anchored phosphodiesterase  4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci. 121 (Pt 1):110-9, 2008.   PMID: 18073242.

Wu S, Cioffi E, Alvarez D, Sayner S, Chen H, Cioffi D, King J, Creighton J, Townsley M, Goodman S, and Stevens T. Essential role of a Ca2+ selective, store operated current (ISOC) in endothelial cell permeability. Determinants of the vascular leak site. Circ Res. 96:856-863, 2005. PMID:15790951.

King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, and Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc. Research, 67: 139-151, 2004. PMID:15020205.

Creighton J, Masada N, Cooper DMF, and Stevens T. Coordinate regulation of membrane cAMP by Ca2+-inhibited adenylyl cyclase and phosphodiesterase activities. Am. J. Physiol Lung Cell Mol Physiol., 284 (1): L100-7, 2003. PMID:12471013.

Cioffi DL, Moore TM, Schaack J, Creighton JR, Cooper DM, and Stevens T. Dominant regulation of interendothelial cell gap formation by calcium inhibited type 6 adenylyl cyclase. J. Cell Biol. 157 (7):1267-78, 2002. PMID:12082084.

Moore T, Norwood N, Creighton J, Babal P, Brough G, Shasby D, and Stevens T. Receptor dependent activation of store-operated Ca2+  entry increases endothelial cell permeability. Am. J. Physiol., 279: L691-L698, 2000.

Norwood N, Moore T, Dean D, Bhattacharjee R, Creighton J, Babal P, and Stevens T. Store operated Ca2+ entry and endothelial cell permeability.  Am. J. Physiol Lung Cell Mol Physiol., 279: L815-L824, 2000.

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