The Ness Lab is led by Timothy J. Ness, MD, PhD, the Simon Gelman Endowed Professor of Anesthesiology. To learn more about Dr. Ness, please visit his faculty profile.
The precise interplay between excitatory and inhibitory influences that exist at a spinal level are being dissected out using behavioral, neurophysiological (spinal dorsal horn, medullary and thalamic extracellular neuronal studies) and immunohistochemical (c-fos induction) studies in this programmatic line of research. Psychophysical studies have identified deficiencies in endogenous pain control systems related to counterirritation - similar deficits have been identified in preclinical experimental models.
A secondary area of research investigation is examining the mechanisms of pain sensation related to exposure to toxic inhalants – specifically the gas chlorine. With collaborator, Sadis Matalon, potential therapeutics for chlorine-induced pain are being examined and tested using locomotor activity as experimental endpoints.
Another area of research interest involves spinal cord injury-related pain. With collaborators in the Department of Physical Medicine and Rehabilitation, the epidemiology, features and treatment of SCI-related pain are being probed.