The Pittet-Wagener Lab is led by Jean-Francois Pittet, M.D., the David Hill Chestnut Endowed Professor of Anesthesiology and Vice Chair and Director of the Division of Critical Care and Perioperative Medicine, and Brant Wagener, M.D., Ph.D.
The laboratory focuses on the basic, clinical and translational mechanisms of acute respiratory distress syndrome (ARDS), coagulopathy and lung infection after acute trauma. After acute trauma, there is a direct interplay between the onset of coagulopathy and ARDS that increases a patient’s opportunity to acquire a nosocomial lung infection. We study these pathophysiologic and molecular mechanisms using animal models, cellular techniques and human clinical data. Our animal work consists of a trauma-hemorrhage-resuscitation model, a Pseudomonas aeruginosa model of lung infection, a stroke/TIA model and a blunt head-trauma model. Our molecular work entails use of flow cytometry, confocal microscopy, FRET, short-circuit current studies with Ussing chambers, Western blotting, ELISA and much more.
See PubMed for Dr. Pittet's publications.
See PubMed for Dr. Wagener's publications.
Active Research projects