Questions & Answers about Trauma Research

1. What is the Resuscitation Outcomes Consortium (ROC)?

The Resuscitation Outcomes Consortium (ROC) is a clinical research network of 10 Regional Clinical Centers (RCCs) and a Data Coordinating Center (DCC) that is studying better ways to help people who have cardiac arrest or severe traumatic injury in the out-of-hospital setting. Cardiac arrest is the loss of mechanical activity of the heart, causing the heart to suddenly stop beating effectively. Blood does not circulate, no pulse can be felt, and the patient collapses suddenly into unconsciousness.  Severe traumatic injury is injury with very low blood pressure and altered level of consciousness or brain injury. The studies test if the use of promising drugs, tools, and techniques in real-world settings improves outcomes for these critically ill patients. ROC studies are being done in Emergency Medical Services (EMS) systems in 10 regions or cities in the United States and Canada.

The National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) is the lead sponsor of the ROC studies. Additional funding is provided by the, Institute of Circulatory and Respiratory Health of the Canadian Institutes of Health Research, the US Army Medical Research and Materiel Command, Defense Research and Development Canada, the Heart and Stroke Foundation of Canada, and the American Heart Association.

Current trauma trials:

Prehospital Tranexamic Acid Use for Traumatic Brain Injury (TXA)