Despite a challenging NIH funding environment, the Center has successfully sustained a very robust extramural portfolio, both in the number and magnitude of interdisciplinary, multi-investigator grants.  As of July 2011, the Center had initiated and currently managed 17 such awards and 5 training programs for a cumulative value of over $20 million total dollars per year (annual total costs).  In each of these, the Center has provided support for the scholarly leadership and intellectual environment, for the integration of fundamental and clinical translation and for planning and management.