Clinical trials are studies, managed by government agencies, educational institutions, private not-for-profit organizations, or commercial businesses, to develop, produce, and evaluate the effectiveness of new treatments and therapies for diseases.

Faculty with Ongoing
Clinical Trials

Vera Bittner, MD, MSPH
Robert Bourge, MD
Brigitta Brott, MD
David Calhoun, MD
Harish Doppalapudi, MD
Jaekyeong Heo, MD
Ami Iskandrian, MD, MACC
Steven Lloyd, MD, PhD
H. Thomas McElderry, MD
Suzanne Oparil, MD
Salpy Pamboukian, MD
Vance Plumb, MD
William Rogers, MD
Jose Tallaj, MD

Vera Bittner, MD
  • Drug trials:

    • Darapladib (Chronic Coronary Heart Disease) - MACE Trial
    • R04607381 (Acute coronary syndroms) - Phase 3
  • Atherothrombosis Intervention
  • Chronic Angina in Women
  • Coronary Outcome by Respiratory Stress Examination - SCORE
  • Gender & Myocardial Infarction - --VIRGO study

Robert Bourge, MD
  • Drug trials:
    • ACT-064992 (Pulmonary Arterial Hypertension/PAH) - SERAPHIN-OL Trial
    • Aliskiren Monotherapy & Aliskiren/Enalapril combination therapy compared to Enalapril Monotherapy (Chronic Heart Failure/CHF) - multiple studes: ATMOSPHERE Trial, CHEST 1 Trial, PATENT 1 & PATENT-2 Trials
    • BAY 63 2521 (Chronic Thromboembolic Pulmonary Hypertension) - CHEST 2 Trial
    • Bosentan and/or Sildenafil (PAH)
    • KW-3902 Injectable Emulsion (HF)
    • Iloprost Inhalation Solution as De Novo or Add-On Therapy with Sitaxsentan Sodium (PAH)
    • Phosphodiesterase Type 5 (PDE5) Inhibitor Tadalafil (PAH)
    • QTI571/Imatinib (PAH) - IMPRES Trial Extension
    • Sitaxsentan Sodium (Pulmonary Arterial Hypertension) - multiple studies
    • Treprostinil Sodium following transition from inhaled Ventavis (iloprost)  (PAH)
    • UT-15C and / or a Phosphodiesterase-5 Inhibitor (PAH)
    • Zp 120 (CHF) - Phase II
  • Advanced Heart Failure/Pulmonary Vascular Disease Research & Training Program Grant
  • Cardiopulmonary Hemodynamics  (PAH)
  • Implantable Hemodynamic Monitor (IHM) - multiple studies, including COMPASS-HF Study
  • Implantable Hemodynamic Monitor (PAH)
  • Management to Patients with Advanced Signs & Symptoms of Heart Failure
  • Multi-Center Retrospective Chart Review of Transition From Long Term Parenteral Prostacyclin Therapy to Oral Therapy - MUST Study
  • Targeted 6-MWT distance threshold approach to Guide Bosentan-Based Therapy
  • Term Parenteral Prostacyclin Therapy to Oral Therapy

Brigitta Brott, MD
  • Drug trials:
    • Ad5FGF-4 in female patients with stable Angina Pectoris - AWARE Trial
    • Alogliptin (Type 2 Diabetes and Acute Coronary Syndrome)
    • Apixaban (Acute Coronary Syndrome) - APPRAISE-2 Phase 3 Trial
    • Cobalt Chromium Stent with Antiproliferative for Restenosis II - COSTAR II Trial
  • Human Recombinant Fibroblast Growth Factor-1 (Severe Coronary Heart Disease)
  • The Sirius Trial

David Calhoun, MD

Drug trials:

  • Aliskiren in combination with Valsartan vs.Valsartan alone (Stage 2 Systolic Hypertension & Type 2 Diabetes Mellitus
  • LY2189265 -  effects on blood pressure & heart rate (Type 2 Diabetes Melllitus)

Harish Doppalapudi, MD
  • Drug trials:
    • PromoteQ® CRT-D and Quartet™ Left Ventricular Heart Lead Trial
    • SAECG (with M2 Risk Stratification)
  • Long-Term Evaluation of the Linox Family ICD Leads Registry
  • Longitudinal Surveillance Registry of the ACUITY Spiral Lead
  • REPLACE Registry
  • Risk Stratification in MADIT II Type Subjects

Jaekyeong Heo, MD

Phase III ASPECT Trial: use of Apadenoson for the detection of Myocardial Perfusion Defects using Single-Photon Emission Computed Tomography/Myocardial Perfusion Imaging - ASPECT Trial

Ami Iskandrian, MD
  • Drug trials:
    • Ad5FGF-4 (Stable Angina)
    • B-Methyl-P-[123I]-Iodophenyl-Pentadecanoic Acid (Iodofiltic Acid 123) for identifying Ischemic Myocardium usin Single Photon Emission Computed Tomography (Acute Coronary Syndrome)
    • Tc-99m Glucarate (Chest Pain Patients suspected with ACS) - Phase II Trial
  • Coronary Obstruction Detection by Molecular Personalized Gene Expression - COMPASS Study
  • Effect of Caffeine Intake on Single Photon Emission Computed Tomography/Myocardial Perfusion Imaging (MPI) in subjects administered Regadenoson - Phase 3b Study
  • Effect of Exercise Training on Myocardial Perfusion and Function in Heart Failure: A Substudy of the ACTION Trial
  • UAB Multi-Pinhole (MP) SPECT Feasibility Protocol

Steven Lloyd, MD, PhD COMPASS 3 MRI Core Lab

Hugh Thomas McElderry, MD
  • CardioFocus Endoscopic Ablation System (Symptomatic Atrial Fibrillation)
  • QuickFlex u Model 1258T Left Heart Pacing Lead
  • RethinQ: Resynchronization Therapy in Normal QRS

Suzanne Oparil, MD

Drug trials:

  • AMG 145 (Hyperlipidemia) - Phase I Trial
  • Exenatide (Type 2 Diabetes Mellitus) - EXSCEL Trial
  • Febuxostat and Allopurinol (Gout & Cardiovascular Comorbidities) - Phase 3b Trial
  • TAK-491 Plus Chlorthalidone fixed-dose combination vs Benicar HCT (Olmesartan Medoxomil-Hydrochlotothiazide) (Moderate to Severe Essential Hypertension) - Phase 3 Trial
  • Sitagliptin (Type 2 Diabetes Mellitus) - TECOS Trial

Salpy Pamboukian, MD
  • Drug studies:
    • Darbepoetin Alfa (HF/ Symptomatic Left Ventricula Systolic Dysfunction/Anemia)
    • Everolimus (RAD) - RAD Trials in Solid Organ Transplantation
  • CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients - CHAMPION Study
  • C-Pulse Implantable Counterpulsation Pump (ICP)
  • DuraHeart Left Ventricular Assist System in patients awaiting transplantation
  • Paracor Ventricular Support System/HeartNet Ventricular Support System
  • Prospective Evaluation of Elastic Restraint to Lessen the Effects of Heart Failure - PEERLESS HF Trial
  • VentrAssist Left Ventricular Assist Device as a Bridge to Cardiac Transplantation - Pivotal Trial and Destination Therapy
  • Wireless, Intermittent Monitoring of Right Heart Pressures in Adult Heart Failure Subjects

Vance Plumb, MD
  • A Frequent Optimization Study using the QuickOpt Method - FREEDOM Study
  • St. Jude Medical: Detect Fluid Early from Intra-Thoracic Impedance Monitoring - DEFEAT-PE Study

William Rogers, MD
  • Drug trials:
    • Aleglitazar Acute Coronary Syndrome/ACS & Type 2 Diabetes Mellitus) - ALECARDIO Trial
    • 2 Aliskiren (ACS) 
    • Darapladib (ACS) - SOLID TIMI 52 Trial
    • Rosuvastatin (Crestor) for low levels of LDL- Cholesterol & elevated levels of C-Reactive Protein - JUPITER Trial
    • Prasugrel & Clopidogrel (ACS) - The TRILOGY ACS Trial
    • Rivaroxaban  (ACS) - The Atlas ACS 2 TIMI 51 Trial
    • SCH 530348 (Atherosclerotic Disease)
    • Saxagliptin (Cardiovascular Death, Myocardial Infarction or Ischaemic Stoke in Patients with Type 2 Diabetes) - SAVOR Trial
    • Vytorin vs Simvastatin Monotherapy (ACS) - IMPROVE IT Trial
  • Escalating Clopidogrel by Involving a Genetic Strategy - ELEVATE-TIMI 56 Trial
  • Women's Ischemia Syndrome Evaluation National Death Index - WISE NDI Trial

Jose Tallaj, MD
  • Drug studies:
    • Alagebrium (Heart Failure/HF) - BREAK DHF Trial
    • Ambrisentan and Sildenafil (Pulmonary Arterial Hypertension)  - ATHENA-1 Trial
    • Bosentan (Mildly Symptomatic Pulmonary Arterial Hypertension) -  EARLY Trial
    • CXL-1020 (Systolic HF) - Phase 2a Trial
    • Lixivaptan (Hyponatremia) - The BALANCE Study
    • Sitaxsentan Sodium (HF) - Phase 2 Trial
  • Cardiac Patient Evaluation - The BALANCE Study
  • Hypertension Disease Management - REVEAL Registry
  • IMPELLA RECOVER LP 2.5 System Versus Intra Aortic Balloon Pump (IABP) in Patients Undergoing Non-Emergent High Risk PCI - PROTECT II Study
  • Medtronic Chronicle Implantable Cardioverter Defibrillator (ICD)
  • Registry to Evaluate Early and Long-Term Pulmonary Arterial
  • Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV - The BALANCE Study
  • Treatment of Preserved Cardiac Function Heart Failure with an Aldosterine Antagonist  - TOPCAT Study