Assistant Professor of Medicine


Biomedical Research Building II, Room 442
1530 3rd Avenue South
Birmingham Alabama 35294-2180




Society Memberships

American Heart Association
The American Physiology Society
The American Society of Biochemistry and Molecular Biology



Research Interests

Myocardial infarction
Pressure overloded
Volume overloaded induced heart failure

Selected Journal

Gladden JD, Zelickson BR, Wei CC, Ulasova E, Zheng J, Ahmed MI, Chen Y, Bamman M, Ballinger S, Darley-Usmar V, Dell'Italia LJ. Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload. Free Radic Biol Med. 2011 Dec 1;51(11):1975-84. Epub 2011 Aug 30.
PMID: 21925594

Chen YW, Pat B, Gladden JD, Zheng J, Powell P, Wei CC, Cui X, Husain A, Dell'italia LJ. Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2251-60. Epub 2011 Mar 18.
PMID: 21421827

Pat B, Chen Y, Killingsworth C, Gladden JD, Shi K, Zheng J, Powell PC, Walcott G, Ahmed MI, Gupta H, Desai R, Wei CC, Hase N, Kobayashi T, Sabri A, Granzier H, Denney T, Tillson M, Dillon AR, Husain A, Dell'italia LJ. Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation. Circulation. 2010 Oct 12;122(15):1488-95. Epub 2010 Sep 27.
PMID: 20876440

Wei CC, Hase N, Inoue Y, Bradley EW, Yahiro E, Li M, Naqvi N, Powell PC, Shi K, Takahashi Y, Saku K, Urata H, Dell'italia LJ, Husain A. Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest. 2010 Apr;120(4):1229-39. doi: 10.1172/JCI39345. Epub 2010 Mar 24.
PMID: 20335663

Belmadani S, Bernal J, Wei CC, Pallero MA, Dell'italia L, Murphy-Ullrich JE, Berecek KH. A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Pathol. 2007 Sep;171(3):777-89. Epub 2007 Jul 19.
PMID: 17640965

PubMed Listings

Chih-Chang Wei, PhD