Professor of Medicine


Zeigler Research Building, Room 1008
703 19th Street South
Birmingham, Alabama 35294-0007





Doctor of Philosophy, Physiology & Biophysics 
University of Illinois, Champaign-Urbana

Master of Science,  Physiology & Biophysics    (Neuroendocrinology)
University of Illinois, Champaign-Urbana

Master of Science, Zoology 
National Taiwan University,  Taipei

Bachelor of Science, Zoology
(Life Science)
National Taiwan University,  Taipei  

Society Memberships

American Association for the Advancement of Science
American Federation for Clinical Research
American Heart Association
American Physiological Society
American Society of Hypertension
Endocrine Society
North American Vascular Biology Organization
Society of Experimental Biology and Medicine
Society for Neuroscience



Research Interests

The role of atrial natriuretic peptide (ANP) and ANP receptors in hypoxia-induced pulmonary hypertension and remodeling and the control of pulmonary artery pressure in normal subjects
The mechanisms by which hypoxic exposure during neonatal lung development leads to increased transforming growth fact (TGF)-beta activation and subsequent pulmonary arterial remodeling and inhibition of alveolar development
ANP's anti-growth and anti-fibrogenic effects that oppose the pro-fibrogenic actions of TGF-beta and angiotensin II
New strategies for targeted delivery of endothelial cells to sites of blood vessel with endoluminal injury

Selected Journal


Xing D, Li P, Gong K, Yang Z, Yu H, Hage FG, Oparil S, Chen YF. Endothelial Cells Overexpressing Interleukin-8 (IL8) Receptors Reduce Inflammatory and Neointimal Responses to Arterial Injury. Circulation. 2012 Feb 23. [Epub ahead of print]
PMID: 22361324 

Olave N, Nicola T, Zhang W, Bulger A, James ML, Oparil S, Chen YF, Ambalavanan N. Transforming growth factor-beta regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 27. [Epub ahead of print]
PMID: 22287612 

Gong K, Xing D, Li P, Aksut B, Ambalavanan N, Yang Q, Nozell SE, Oparil S, Chen YF. Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling. Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L899-907. Epub 2011 Sep 16.
PMID: 21926264

Xing D, Gong K, Feng W, Nozell SE, Chen YF, Chatham JC, Oparil S. O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells. PLoS One. 2011;6(8):e24021. Epub 2011 Aug 31.
PMID: 21904602

Gong K, Xing D, Li P, Hilgers RH, Hage FG, Oparil S, Chen YF. cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells. Mol Endocrinol. 2011 Oct;25(10):1794-803. Epub 2011 Aug 25.
PMID: 21868450

PubMed Listings

Yiu-Fai Chen, PhD