Martin Young, DPhil


Associate Professor of Medicine

Young-martin

Contact Information

Zeigler Building, Room 308
1530 3rd Avenue South
Birmingham, Alabama 35294-0006

Email Address: meyoung@uab.edu  
Office Phone: (205) 934-2328
Office Fax: (205) 975-5150



Professional


Training

Postdoctoral Training
University of Texas-Houston
Boston University


Doctor of Philosophy (Biochemistry)
University of Oxford


Master of Science
University of Oxford


Bachelor or Science
University of Oxford 


Research


Research Interests

Pathogenesis of myocardial contractile dysfunction observed during obesity and diabetes mellitus
Influence of environmental factors (time-of-day & nutrition) on cardiovascular health and disease 
Cardiomyocytes and the circadian clock
Humoral factors: nutrients (glucose & fatty acids)
Increased fatty acid availability and the accumulation of intramyocellular fatty acid derivatives


Selected Journal

Articles

Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR. Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 2012 Feb;32(4):740-50. Epub 2011 Dec 12.
PMID: 22158969


Durgan DJ, Pat BM, Laczy B, Bradley JA, Tsai JY, Grenett MH, Ratcliffe WF, Brewer RA, Nagendran J, Villegas-Montoya C, Zou C, Zou L, Johnson RL Jr, Dyck JR, Bray MS, Gamble KL, Chatham JC, Young ME. O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. J Biol Chem. 2011  Dec 30;286(52):44606-19. Epub 2011 Nov 8.
PMID: 22069332


Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY. Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms. J Biol Rhythms. 2011 Oct;26(5):412-22.
PMID: 21921295


Durgan DJ, Tsai JY, Grenett MH, Pat BM, Ratcliffe WF, Villegas-Montoya C, Garvey ME, Nagendran J, Dyck JR, Bray MS, Gamble KL, Gimble JM, Young ME. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int. 2011 Apr;28(3):187-203.
PMID: 21452915


Bray MS, Young ME. Regulation of fatty acid metabolism by cell autonomous circadian clocks: time to fatten up on information? J Biol Chem. 2011 Apr 8;286(14):11883-9. Epub 2011 Feb 4. Review.
PMID: 21296875


 PubMed Listings

 Martin E. Young, DPhil

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