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UAB is one of the seven inaugural NIH-designated Centers for AIDS Research established in 1988 and a world leader in HIV/AIDS research and patient care. UAB has been among the first to make the newest, most effective treatments available to patients, including the three-drug combination that today is the standard of care. From the field, a UAB-led team discovered the simian virus linked to all major HIV-1 variants and traced the exact route of HIV's spread to humans. U.S. News & World Report ranks the AIDS program No. 8 among "America's Best Graduate Schools," and the journal Science recently highlighted Birmingham and UAB's 1917 Clinic among 10 cities nationally excelling in efforts to combat the disease.