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Core Biostatistics

Core D redDURING THE UPCOMING BUDGET YEAR, CFAR BIOSTATS AND ANALYSIS CORE SERVICES WILL BE MERGED INTO THE CFAR CLINICAL CORE. CHECK BACK FOR INFORMATION REGARDING THESE CHANGES.
The purpose of Biostatistics and Analysis Core is primarily to provide statistical, epidemiologic, health services research and bioinformatics support to CFAR investigators for the development of research proposals including data management and quality control with analyses. This is accomplished by a collaborative team of investigators who provide input on study design and analyses as well as logistical issues and problems impacting the quality and integrity of studies in addition to advice on literature interpretation, assessment of new methodologies and support for studying unique aspects of HIV in the US Deep South. The range of studies include pilot data and phase I clinical trials for drug discovery to pathogenesis, prevention (both primary and secondary) and the "new" natural history of HIV infection in the treatment era. The type of studies include both genetic and non-genetic such as observational designs, clinical research, health services research, health economic modeling and other evaluations such as mixed treatment comparisons, indirect treatment comparisons and causal modeling.

Services


The Biostatistics and Analysis Core serves as the centralized resource to provide access to statistical expertise and data management to support research programs and projects conducted by CFAR members. The value added to the CFAR scientific mission is that the Biostatistics and Analysis Core provides statistical, data management and computing support for a number of purposes: Statistical design of experiments to efficiently address scientific questions; Sample size estimation to assist investigators in determining study feasibility; Data analysis of preliminary data to be used in hypothesis generation; Secondary data analyses of databases; Guidance in structuring databases to ensure that required data to address scientific issues can be easily retrieved and analyzed; Availability of software resources for statistical and data management purposes. Acquisition of some software is costly, but the CFAR Biostatistics and Analysis Core utilizes the software across CFAR members and, in some cases, across other applications, to minimize the cost to the CFAR.


Publications


1.     Dionne-Odom J, Welty TK, Westfall AO, Chi BH, Ekouevi DK, Kasaro M, Tih PM, Tita AT. Factors Associated with PMTCT Cascade Completion in Four African Countries. AIDS Res Treat. 2016; 2016:2403936.
PMID: 27872760
PMCID: PMC5107823


2.     Eaton E, Tamhane A, Burkholder G, Willig J, Saag M, Mugavero M. Unanticipated Effects of New Drug Availability on Antiretroviral Durability: Implications for Comparative Effectiveness Research. Open Forum Infect Dis 2016; 16:3(2). doi: 10.1093/ofid/ofw109
PMID: 27419181
PMCID: PMC4943538


3.     Eaton E, Tamhane A, Saag M, , Mugavero M, Kilgore M. Cost Considerations in the Current ARV Era. AIDS 2016. 30(14): 2115-9. doi: 10.1097/QAD.0000000000001120.
PMID
: 27088319
PMCID: Not assigned


4.     Eaton E, Gravett M, Tamhane A, Mugavero M. ART Initiation, Regardless of Regimen, is Associated with Improvement in Self-reported Depression. Clin Infect Dis 2017 (Accepted).
PMID: Not assigned
PMCID: Not assigned


5.     Elopre L, Westfall AO, Mugavero MJ, Zinski A, Burkholder G, Hook EW, Van Wagoner N. Predictors of HIV Disclosure in Infected Persons Presenting to Establish Care. AIDS Behav. 2016; 20(1):147-54. doi: 10.1007/s10461-015-1060-8.
PMID: 25855046
PMCID: Not assigned


6.     Elopre L, Kudroff K, Westfall AO, Overton E, Mugavero MJ The Right People, Right Places, and Right Practices: Disparities in PrEP Access Among African American Men, Women, and MSM in the Deep South. J Acquir Immune Defic Sundr 2017; 74(1): 56-9.
PMID: 27552156
PMCID: Not assigned


7.     Franco R, Overton T, Tamhane A, Forsythe J, Rodgers J, Schexnayder J, Guthrie D, Thogaripally S, Zinski A, Saag M, Mugavero M, Wang H, Gailbraith J. Characterizing Failure to Establish Hepatitis C Care of Baby Boomers Diagnosed in the Emergency Department. Open Forum Infect Dis 2016: ofw211v1-ofw211. doi: 10.1093/ofid/ofw211
PMID: 28066793
PMCID: PMC5198583


8.     Galbraith JW, Willig JH, Rodgers JB, Donnelly JP, Westfall AO, Ross-Davis KL, Heath SL. Evolution and Escalation of an Emergency Department Routine, Opt-out HIV Screening and Linkage-to-Care Program. Public Health Rep. 2016;131 Suppl 1:96-106.
PMID:26862235
PMCID: PMC4720611


9.     Gundacker N, Carrera J, Castillo M, Abrego L, Diaz Y, Valenzuela J, Tamhane A, Moreno B, Pascale J, Tesh R, Lopez-Verges S. The clinical manifestations of Punta Toro virus group in Panama 2009. Emerg Infect Dis 2017 (Accepted).
PMID: Not assigned
PMCID: Not assigned


10.  Navarro-Millán I, Darrah E, Westfall AO, Mikuls TR, Reynolds RJ, Danila MI, Curtis JR; CLEAR Investigators., Rosen A, Bridges SL Jr. Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans. Arthritis Res Ther. 2016; 18(1):241.
PMID: 27770831
PMCID: PMC5075170


11.  Osborne JD, Wyatt M, Westfall AO, Willig J, Bethard S, Gordon G. Efficient identification of nationally mandated reportable cancer cases using natural language processing and machine learning. J Am Med Inform Assoc. 2016; 23(6):1077-1084. doi: 10.1093/jamia/ocw006.
PMID: 27026618
PMCID: PMC5070519


12.  Saag L, Tamhane A, Batey S, et al. Mental Health Service Utilization and Medication Non-Adherence Among Patients with HIV (AIDS Care: Revise and Resubmit).
PMID: Not assigned
PMCID: Not assigned


13.  Saag MS, Westfall AO, Cole SR, Mathews WC, Drozd DR, Mayer KH, Burkholder GA, Kitahata M, Maiese EM; CFAR Network of Integrated Clinical Systems (CNICS). Factors Associated With the Selection of Initial Antiretroviral Therapy From 2009 to 2012. J Acquir Immune Defic Syndr. 2017; 74(1): 60-4.
PMID: 27552153
PMCID: PMC5140679


14.  Schaff K, Smith S, Duverger A, Wagner F, Wolschendorf F, Westfall AO, Kutsch O, Sun J. Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis. Sci Rep. 2017; 7:42101. doi: 10.1038/srep42101.
PMID: 28176854
PMCID: PMC5296758


15.  Tamhane A, Westfall AO, Burkholder G, Cutter G. Prevalence Odds Ratio Versus Prevalence Ratio: Choice Comes with Consequences. Stat Med 2016. doi: 10.1002/sim.7059.
PMID: 27460748
PMCID: PMC5135596


16.  Van Wagoner N, Elopre L, Westfall AO, Mugavero MJ, Turan J, Hook EW. Reported Church Attendance at the Time of Entry into HIV Care is Associated with Viral Load Suppression at 12 Months. AIDS Behav. 2016;20(8):1706-12. doi: 10.1007/s10461-016-1347-4.
PMID: 26936149
PMCID: Not assigned


Contact Information


Core D.smaller pic                                                    Pictured: Dr. Ashutosh Tamhane, Andy Westfall and Dr. Gary Cutter (no longer affiliated)

Director
Dustin M Long, PhD
Email: dmlong@uab.edu

Other Leadership

Andy Westfall, MS
Email: AndyW@uab.edu 

Ashutosh Tamhane, MD, PhD
Email: tamhane@uab.edu 

University of Alabama at Birmingham
Bevill Biomedical Building
CFAR Offices/RISC Suite
2nd Floor
Rooms 206 & 256