The Clinical Core has been a cornerstone of the UAB CFAR for over two decades. Iterative expansion of the depth and breadth of core services have been implemented to meet changing investigator needs, to address new knowledge gaps and accompanying shifts in the scientific agenda, and to study the evolving HIV epidemic. Building upon a long-standing history of successful service provision resulting in high impact scientific discovery, the importance and future direction of the Clinical Core is as dynamic as it has ever been. Clinical and behavioral scientists need novel data elements that are not historically captured and housed in the expansive clinical database maintained by the Core. There is also an emerging need for research coordination and health informatics services to implement prospective research studies that are in keeping with the US National HIV/AIDS Strategy. Basic and translational scientists increasingly require biological specimens that are not routinely captured and banked, often from unique patient phenotypes, requiring targeted identification and sample collection. Accordingly, the Clinical Core is rapidly adapting and instituting innovative and expanded services in response to user needs and to support the overarching UAB CFAR scientific mission and pillars of prevention, drug discovery, pathogenesis, and the natural history of HIV in the modern treatment era.
Patient Samples and Data Services
The Clinical Core maintains and provides patient samples from a comprehensive and efficient Specimen Repository obtained from well-characterized patients for collaborative investigations involving multiple research disciplines. Contact the Clinical Core to have samples processed or obtain samples for research purposes. The Core also provides samples to other CFARs and outside investigators to aid scientific research.
- Fresh blood
- Peripheral blood mononuclear cells
- Mucosal secretions
- Mucosal biopsies
- Lymph node biopsies
- Skin biopsies
The Core also provides plasmaphoresis and leukophoresis to CFAR members and network organizations in order to provide a greater volume of samples from a few patients with unique characteristics (e.g., long term nonprogressors).
The Clinical Core also provides a Computerized Database and Informatics Service to store and access complex, interactive data to assist with study design and to conduct appropriate data analysis. For more information, visit the UAB 1917 Clinic Cohort website.
- The Core works with young and established UAB investigators as well as outside researchers to provide data queries and identification of potential research subjects who meet clinical or scientific criteria for retrospective or prospective translational research studies.
- The Clinical Core will collaborate with other CFARs and institutions in the form of computerized informatics and biostatistics expertise to assist with launching their own databases.
Clinical Research Training Services are provided at all levels (from students to research staff representing a variety of disciplines to seasoned faculty updating their skills).
- Provide training for a variety of domestic health care workers and students with potential HIV research career interests.
- Collaborate with the Biostatistical Core to provide research methods, database, and statistical training of local and international investigators.
- Coordinate with the Developmental Core to match trainees or new researchers to appropriate mentors and projects.
- Collaborate with the International Core to provide leadership and expertise to build research capacity in international sites, including the long-distance exchange of information as well as on-site research training and advice.
Publications Describing New Work Supported by the Core
1. Achenbach CJ, Buchanan AL, Cole SR, Hou L, Mugavero MJ, Crane HM, Moore RD, Haubrich RH, Gopal S, Eron JJ, Hunt PW, Rodriguez B, Mayer K, Saag MS, Kitahata MM. HIV viremia and incidence of non-Hodgkin lymphoma in patients successfully treated with antiretroviral therapy. Clin Infect Dis 2014;58(11):1599-606.
PMID number: 24523217
PMCID number: PMC4017888
2. Aweeka F, Hu C, Huang L, Best B, Stek A, Lizak P, Burchett S, Read J, Watts H, Mirochnick M, Capparelli E. Alteration in cytochrome p450 3a4 activity as measured by a urine cortisol assay in HIV-1-infected pregnant women and relationship to antiretroviral pharmacokinetics. HIV Med 2015;16(3):176-83.
PMID number: 25407158
PMCID number: PMC4320673
3. Bachmann LH, Grimley DM, Gao H, Aban I, Chen H, Raper JL, Saag MS, Rhodes SD, Hook EW, 3rd. Impact of a computer-assisted, provider-delivered intervention on sexual risk behaviors in HIV-positive men who have sex with men (MSM) in a primary care setting. AIDS Educ Prev 2013;25(2):87-101.
PMID number: 23514077
4. Baheti G, King JR, Acosta EP, Fletcher CV. Age-related differences in plasma and intracellular tenofovir concentrations in HIV-1-infected children, adolescents and adults. AIDS 2013;27(2):221-25.
PMID number: 23032419
PMCID number: PMC3586236
5. Bengtson AM, Pence BW, O'Donnell J, Thielman N, Heine A, Zinski A, Modi R, McGuinness T, Gaynes B. Improvements in depression and changes in quality of life among HIV-infected adults. AIDS Care 2015;27(1):47-53.
PMID number: 25105320
6. Bess KD, Adams J, Watt MH, O'Donnell JK, Gaynes BN, Thielman NM, Heine A, Zinski A, Raper JL, Pence BW. Providers' attitudes towards treating depression and self-reported depression treatment practices in HIV outpatient care. AIDS Patient Care STDS 2013;27(3):171-80.
PMID number: 23442030
PMCID number: PMC3595951
7. Bet A, Sterrett S, Sato A, Bansal A, Goepfert PA. Characterization of t-cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 vaccine. J Acquir Immune Defic Syndr 2014;65(2):142-50.
PMID number: 24442221
PMCID number: PMC3896890
8. Bharaj P, Chahar HS, Alozie OK, Rodarte L, Bansal A, Goepfert PA, Dwivedi A, Manjunath N, Shankar P. Characterization of programmed death-1 homologue-1 (pd-1h) expression and function in normal and HIV infected individuals. PLoS One 2014;9(10):e109103.
PMID number: 25279955
PMCID number: PMC4184823
9. Blashill AJ, Mayer KH, Crane HM, Baker JS, Willig JH, Willig AL, Grasso C, O'Cleirigh C, Safren SA. Body mass index, depression, and condom use among HIV-infected men who have sex with men: A longitudinal moderation analysis. Arch Sex Behav 2014;43(4):729-34.
PMID number: 23979782
PMCID number: PMC3933471
10. Boehme AK, Davies SL, Moneyham L, Shrestha S, Schumacher J, Kempf MC. A qualitative study on factors impacting HIV care adherence among postpartum HIV-infected women in the rural southeastern USA. AIDS Care 2014;26(5):574-81.
PMID number: 24116662
11. Bowers NL, Helton ES, Huijbregts RP, Goepfert PA, Heath SL, Hel Z. Immune suppression by neutrophils in HIV-1 infection: Role of PD-L1/PD-1 pathway. PLoS Pathog 2014;10(3):e1003993.
PMID number: 24626392
PMCID number: 3953441
12. Burkholder GA, Tamhane AR, Appell LE, Willig JH, Saag MS, Raper JL, Westfall AO, Mugavero MJ. Viral suppression is associated with increased likelihood of colorectal cancer screening among persons living with HIV/AIDS. AIDS Res Hum Retroviruses 2014. [Epub ahead of print]
PMID number: 25435340
13. Buscher A, Mugavero M, Westfall AO, Keruly J, Moore R, Drainoni ML, Sullivan M, Wilson TE, Rodriguez A, Metsch L, Gardner L, Marks G, Malitz F, Giordano TP. The association of clinical follow-up intervals in HIV-infected persons with viral suppression on subsequent viral suppression. AIDS Patient Care STDS 2013;27(8):459-66.
PMID number: 23886048
PMCID number: PMC3739946
14. Cole SR, Lau B, Eron JJ, Brookhart MA, Kitahata MM, Martin JN, Mathews WC, Mugavero MJ. Estimation of the standardized risk difference and ratio in a competing risks framework: Application to injection drug use and progression to AIDS after initiation of antiretroviral therapy. Am J Epidemiol 2015;181(4):238-45.
PMID number: 24966220
PMCID number: PMC4325676
15. Cressey TR, Best BM, Achalapong J, Stek A, Wang J, Chotivanich N, Yuthavisuthi P, Suriyachai P, Prommas S, Shapiro DE, Watts DH, Smith E, Capparelli E, Kreitchmann R, Mirochnick M. Reduced indinavir exposure during pregnancy. Br J Clin Pharmacol 2013;76(3):475-83.
PMID number: 23305215
PMCID number: PMC3769674
16. Cropsey KL, Hendricks PS, Jardin B, Clark CB, Katiyar N, Willig J, Mugavero M, Raper JL, Saag M, Carpenter MJ. A pilot study of screening, brief intervention, and referral for treatment (SBIRT) in non-treatment seeking smokers with HIV. Addict Behav 2013;38(10):2541-46.
PMID number: 23787030
PMCID number: PMC3725186
17. Crowell CS, Huo Y, Tassiopoulos K, Malee KM, Yogev R, Hazra R, Rutstein RM, Nichols SL, Smith RA, Williams PL, Oleske J, Muller WJ. Early viral suppression improves neurocognitive outcomes in HIV-infected children. AIDS 2015;29(3):295-304.
PMID number: 25686678
PMCID number: PMC4332557
18. Dombrowski JC, Kitahata MM, Van Rompaey SE, Crane HM, Mugavero MJ, Eron JJ, Boswell SL, Rodriguez B, Mathews WC, Martin JN, Moore RD, Golden MR. High levels of antiretroviral use and viral suppression among persons in HIV care in the United States, 2010. J Acquir Immune Defic Syndr 2013;63(3):299-306.
PMID number: 23572013
PMCID number: PMC3691075
19. Duverger A, Wolschendorf F, Zhang M, Wagner F, Hatcher B, Jones J, Cron RQ, van der Sluis RM, Jeeninga RE, Berkhout B, Kutsch O. An ap-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infection. J Virol 2013;87(4):2264-77.
PMID number: 23236059
PMCID number: PMC3571467
20. Edwards JK, Cole SR, Westreich D, Moore R, Mathews C, Geng E, Eron JJ, Mugavero MJ. Loss to clinic and five-year mortality among HIV-infected antiretroviral therapy initiators. PLoS One 2014;9(7):e102305.
PMID number: 25010739
PMCID number: PMC4092142
21. Edwards M, Quinlivan EB, Bess K, Gaynes BN, Heine A, Zinski A, Modi R, Pence BW. Implementation of phq-9 depression screening for HIV-infected patients in a real-world setting. J Assoc Nurses AIDS Care 2014;25(3):243-52.
PMID number: 24103743
PMCID number: PMC3976873
22. Elias JA, Rossman MD, Zurier RB, Daniele RP. Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process. Am Rev Respir Dis 1985;131(1):94-99.
PMID number: 3966717
23. Engsig FN, Zangerle R, Katsarou O, Dabis F, Reiss P, Gill J, Porter K, Sabin C, Riordan A, Fatkenheuer G, Gutierrez F, Raffi F, Kirk O, Mary-Krause M, Stephan C, de Olalla PG, Guest J, Samji H, Castagna A, d'Arminio Monforte A, Skaletz-Rorowski A, Ramos J, Lapadula G, MUSsini C, Force L, Meyer L, Lampe F, Boufassa F, Bucher HC, De Wit S, Burkholder GA, Teira R, JUStice AC, Sterling TR, H MC, Gerstoft J, Grarup J, May M, Chene G, Ingle SM, Sterne J, Obel N. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery. Clin Infect Dis 2014;58(9):1312-21.
PMID number: 24457342
24. Fletcher FE, Buchberg M, Schover LR, Basen-Engquist K, Kempf MC, Arduino RC, Vidrine DJ. Perceptions of barriers and facilitators to cervical cancer screening among low-income, HIV-infected women from an integrated HIV clinic. AIDS Care 2014;26(10):1229-35.
PMID number: 24635664
PMCID number: PMC4087052
25. Franco RA, Saag MS. When to start antiretroviral therapy: As soon as possible. BMC Med 2013;11:147.
PMID number: 23767762
PMCID number: PMC3682940
26. Franco RA, Tamhane A, Overton ET. Impact of poor retention in HIV medical care on hepatitis b vaccination. J Int Assoc Provid AIDS Care 2014. [Epub ahead of print]
PMID number: 25301284
27. Gakumo CA, Enah CC, Vance DE, Sahinoglu E, Raper JL. "Keep it simple": Older African Americans' preferences for a health literacy intervention in HIV management. Patient Prefer Adherence 2015;9:217-23.
PMID number: 25678780
PMCID number: PMC4319466
28. Galbraith JW, Donnelly JP, Franco RA, Overton ET, Rodgers JB, Wang HE. National estimates of healthcare utilization by individuals with Hepatitis C virus infection in the United States. Clin Infect Dis 2014;59(6):755-64.
PMID number: 24917659
PMCID number: PMC4200046
29. Galbraith JW, Franco RA, Donnelly JP, Rodgers JB, Morgan JM, Viles AF, Overton ET, Saag MS, Wang HE. Unrecognized chronic Hepatitis C virus infection among baby boomers in the emergency department. Hepatology 2015;61(3):776-82.
PMID number: 25179527
30. Goepfert PA, Elizaga ML, Seaton K, Tomaras GD, Montefiori DC, Sato A, Hural J, DeRosa SC, Kalams SA, McElrath MJ, Keefer MC, Baden LR, Lama JR, Sanchez J, Mulligan MJ, Buchbinder SP, Hammer SM, Koblin BA, Pensiero M, Butler C, Moss B, Robinson HL. Specificity and 6-month durability of immune responses induced by DNA and recombinant modified vaccinia ankara vaccines expressing HIV-1 virus-like particles. J Infect Dis 2014;210(1):99-110.
PMID number: 24403557
PMCID number: PMC4072895
31. Gopal S, Patel MR, Achenbach CJ, Yanik EL, Cole SR, Napravnik S, Burkholder GA, Mathews WC, Rodriguez B, Deeks SG, Mayer KH, Moore RD, Kitahata MM, Richards KL, Eron JJ. Lymphoma immune reconstitution inflammatory syndrome in the Center for AIDS Research Network of Integrated Clinical Systems Cohort. Clin Infect Dis 2014;59(2):279-86.
PMID number: 24755860
PMCID number: PMC4102912
32. Gopal S, Patel MR, Yanik EL, Cole SR, Achenbach CJ, Napravnik S, Burkholder GA, Reid EG, Rodriguez B, Deeks SG, Mayer KH, Moore RD, Kitahata MM, Eron JJ, Richards KL. Temporal trends in presentation and survival for HIV-associated lymphoma in the antiretroviral therapy era. J Natl Cancer Inst 2013;105(16):1221-59.
PMID number: 23892362
PMCID number: PMC3748003
33. Gopal S, Patel MR, Yanik EL, Cole SR, Achenbach CJ, Napravnik S, Burkholder GA, Reid EG, Rodriguez B, Deeks SG, Mayer KH, Moore RD, Kitahata MM, Richards KL, Eron JJ. Association of early HIV viremia with mortality after HIV-associated lymphoma. AIDS 2013;27(15):2365-73.
PMID number: 23736149
PMCID number: PMC3773290
34. Grant JS, Vance DE, Keltner NL, White W, Raper JL. Reasons why persons living with HIV include individuals in their chosen families. J Assoc Nurses AIDS Care 2013;24(1):50-60.
PMID number: 22853884
35. Hall HI, Tang T, Westfall AO, Mugavero MJ. HIV care visits and time to viral suppression, 19 U.S. Jurisdictions, and implications for treatment, prevention and the national HIV/AIDS strategy. PLoS One 2013;8(12):e84318.
PMID number: 24391937
PMCID number: PMC3877252
36. Hanna DB, Buchacz K, Gebo KA, Hessol NA, Horberg MA, Jacobson LP, Kirk GD, Kitahata MM, Korthuis PT, Moore RD, Napravnik S, Patel P, Silverberg MJ, Sterling TR, Willig JH, Collier A, Samji H, Thorne JE, Althoff KN, Martin JN, Rodriguez B, Stuart EA, Gange SJ. Association between U.S. State AIDS Drug Assistance Program (ADAP) features and HIV antiretroviral therapy initiation, 2001-2009. PLoS One 2013;8(11):e78952.
PMID number: 24260137
PMCID number: PMC3832515
37. Himes SK, Scheidweiler KB, Tassiopoulos K, Kacanek D, Hazra R, Rich K, Huestis MA. Development and validation of the first liquid chromatography-tandem mass spectrometry assay for simultaneoUS quantification of multiple antiretrovirals in meconium. Anal Chem 2013;85(3):1896-904.
PMID number: 23256731
PMCID number: PMC3638039
38. Horberg MA, Hurley LB, Silverberg MJ, Klein DB, Quesenberry CP, Mugavero MJ. Missed office visits and risk of mortality among HIV-infected subjects in a large healthcare system in the United States. AIDS Patient Care STDS 2013;27(8):442-49.
PMID number: 23869466
PMCID number: PMC3739947
39. Howe CJ, Cole SR, Napravnik S, Kaufman JS, Adimora AA, Elston B, Eron JJ, Jr., Mugavero MJ. The role of at-risk alcohol/drug use and treatment in appointment attendance and virologic suppression among HIV(+) African Americans. AIDS Res Hum Retroviruses 2014;30(3):233-40.
PMID number: 24325326
PMCID number: PMC3938941
40. Howe CJ, Napravnik S, Cole SR, Kaufman JS, Adimora AA, Elston B, Eron JJ, Jr., Mugavero MJ. African american race and HIV virological suppression: Beyond disparities in clinic attendance. Am J Epidemiol 2014;179(12):1484-92.
*CFAR members are bolded
Michael Mugavero, MD, MHSC
Greer A. Burkholder, MD, MSPH (Database and Informatics)
Sonya L. Heath, MD (Specimen Repository)
E. Turner Overton, MD (Education and Training)
University of Alabama at Birmingham
Community Care Building (CCB)
908 20th Street South
Birmingham AL 35294-2050