The Clinical Core has been a cornerstone of the UAB CFAR for over two decades. Iterative expansion of the depth and breadth of core services have been implemented to meet changing investigator needs, to address new knowledge gaps and accompanying shifts in the scientific agenda, and to study the evolving HIV epidemic. Building upon a long-standing history of successful service provision resulting in high impact scientific discovery, the importance and future direction of the Clinical Core is as dynamic as it has ever been. Clinical and behavioral scientists need novel data elements that are not historically captured and housed in the expansive clinical database maintained by the Core. There is also an emerging need for research coordination and health informatics services to implement prospective research studies that are in keeping with the US National HIV/AIDS Strategy. Basic and translational scientists increasingly require biological specimens that are not routinely captured and banked, often from unique patient phenotypes, requiring targeted identification and sample collection. Accordingly, the Clinical Core is rapidly adapting and instituting innovative and expanded services in response to user needs and to support the overarching UAB CFAR scientific mission and pillars of prevention, drug discovery, pathogenesis, and the natural history of HIV in the modern treatment era.
Patient Samples and Data Services
The Clinical Core maintains and provides patient samples from a comprehensive and efficient Specimen Repository obtained from well-characterized patients for collaborative investigations involving multiple research disciplines. Contact the Clinical Core to have samples processed or obtain samples for research purposes. The Core also provides samples to other CFARs and outside investigators to aid scientific research.
- Fresh blood
- Peripheral blood mononuclear cells
- Mucosal secretions
- Mucosal biopsies
- Lymph node biopsies
- Skin biopsies
The Core also provides plasmaphoresis and leukophoresis to CFAR members and network organizations in order to provide a greater volume of samples from a few patients with unique characteristics (e.g., long term nonprogressors).
The Clinical Core also provides a Computerized Database and Informatics Service to store and access complex, interactive data to assist with study design and to conduct appropriate data analysis. For more information, visit the UAB 1917 Clinic Cohort website or review the Database and Informatics Data Collection information.
- The Core works with young and established UAB investigators as well as outside researchers to provide data queries and identification of potential research subjects who meet clinical or scientific criteria for retrospective or prospective translational research studies.
- The Clinical Core will collaborate with other CFARs and institutions in the form of computerized informatics and biostatistics expertise to assist with launching their own databases.
Clinical Research Training Services are provided at all levels (from students to research staff representing a variety of disciplines to seasoned faculty updating their skills).
- Provide training for a variety of domestic health care workers and students with potential HIV research career interests.
- Collaborate with the Biostatistical Core to provide research methods, database, and statistical training of local and international investigators.
- Coordinate with the Developmental Core to match trainees or new researchers to appropriate mentors and projects.
- Collaborate with the International Core to provide leadership and expertise to build research capacity in international sites, including the long-distance exchange of information as well as on-site research training and advice.
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Michael Mugavero, MD, MHSC
Greer A. Burkholder, MD, MSPH (Database and Informatics)
Sonya L. Heath, MD (Specimen Repository)
E. Turner Overton, MD (Education and Training)
University of Alabama at Birmingham
Community Care Building (CCB)
908 20th Street South
Birmingham AL 35294-2050