UnitBar
ClinicalFormThe Clinical Core has been a cornerstone of the UAB CFAR for over two decades, enhancing all aspects of human HIV research. The importance and future direction of the Clinical Core is as dynamic as it has ever been, meeting changing investigator needs, addressing new knowledge gaps and accompanying shifts in the scientific agenda, and studying the evolving HIV epidemic. Enhanced synergies within the Core allows for more timely and seamless service delivery, and for service expansion to allow for “on demand” specimen capture and prospective research recruitment, study coordination and protocol implementation to a record number of investigators.

We provide easy access to comprehensive clinical services, resources and expertise supporting basic science, behavioral, epidemiological, translational, clinical and public health research. Clinical Research Training Services are provided at all levels including the 1917 Clinic Cohort which is an opportunity for investigators from across campus to meet to discuss HIV research. The Clinical Core is rapidly adapting and instituting innovative and expanded services in response to user needs and to support the overarching UAB CFAR scientific mission and pillars of prevention, drug discovery, pathogenesis, and the natural history of HIV in the modern treatment era.

Aims

Clinical Core Aims

Aim 1: To provide Computerized Database and Informatics Services along with expertise in management and quality assurance of complex, interactive data derived from multiple electronic data sources, generation of analysis-ready datasets, and development of health informatics software.

Aim 2: To provide a comprehensive and efficient Specimen Repository obtained from well-characterized patients along with expertise in identification of study participants to achieve investigator objectives, and ready provision and processing of existing and ad hoc biological samples.

Aim 3. To provide Study Coordination, Recruitment, and Implementation Services along with the expertise to properly staff and prepare logistics for successful performance of prospective observational and point-of-care interventional studies within the UAB 1917 HIV Clinic.

Aim 4. To provide and coordinate Clinical and Research Education and Training Services along with expertise in matching trainee needs with available services and resources offered by Core C.


Database & Informatics


Database & Informatics Services

The Clinical Core provides a Computerized Database and Informatics Service to store and access complex, interactive data to assist with study design and to conduct appropriate data analysis.
• Assists young and established UAB investigators as well as outside researchers to provide data queries and identification of potential research subjects who meet clinical or scientific criteria for retrospective or prospective translational research studies.
• Collaborates with other CFARs and institutions in the form of computerized informatics and biostatistics expertise to assist with launching their own databases.
• Consults on design of database management plans for individual projects.
• Consults on the operation of project-specific systems.
• Assists or consults in design and creation of data collection instruments and forms.
• Database coordination with other Cores and Centers.
• Prepares datasets suitable for statistical analysis.


Specimen Repository


Specimen Repository Services

The Clinical Core maintains and provides patient samples from a comprehensive and efficient Specimen Repository obtained from well-characterized patients for collaborative investigations involving multiple research disciplines. Contact the Clinical Core to have samples processed or obtain samples for research purposes. The Core also provides samples to other CFARs and outside investigators to aid scientific research.

Types of existing specimens available: :
• Fresh blood,
• Plasma
• Serum
• Peripheral blood mononuclear cells
• Mucosal secretions
• Mucosal biopsies, lymph node biopsies, skin biopsies

Types of services available:
• Provides Identification and collection of clinical samples.
• Provides access to stored samples from well characterized patients..
• Provides access to expertise in the development and implementation of HIV vaccine trials.
• Provides plasmaphoresis and leukophoresis to CFAR members and network organizations in order to provide a greater volume of samples from a few patients with unique characteristics (e.g., long term nonprogressors).


Research Coordination


Research Coordination Services

The Clinical Core offers Research Coordination, Recruitment and Implementation Services including support with recruitment, enrollment, protocol design development and implementation. Core personnel are available to assist with regulatory and study coordinator support, data and specimen collection, web-based tracking and data entry, database design and data management. Ongoing collaborations exist with the CFAR Network of Integrated Clinical Systems and other national and international cohort studies.
• Reviews and critiques existing / draft protocols.
• Collaborates in development of study design (experimental and observational).
• Assists with IRB application.
• Facilitates access to expertise in multiple sub-disciplines of HIV research including hepatology, cardiology, neurology, nephrology, hematology/oncology, obstetrics and gynecology, and psychiatry.
• Consults on study implementation, operations, and monitoring adherence to protocol.
• Assists with data collection or identification and assessment of appropriateness to research hypotheses.
• Develops clinically appropriate analysis plans and strategies.
• Assists with budget planning for grant proposals, estimation of costs.
• Provides letters of support, biosketch, background information, other-support pages.
• Assists with clinical epidemiologic analytic computations.
• Provides interpretive analyses of clinical, laboratory and basic science results.
• Provides collaborative preparation of publications and presentations.
• Progress report check ins with investigators (proactive tracking form)


Education


Education and Training Services

The Clinical Core provides Clinical and Research Education and Training Services providing coordination of training sessions including 1917 Clinic Cohort Meetings and 1917 Clinic Provider meetings. Additional services including research consultation and regulatory training are provided to a wide range of trainees.
• Training ID Fellows
• IPE (inter-professional education)
• Weekly Cohort Research Roundtable Interactive Discussions
• Monthly Provider meetings
• Monthly 1917 Clinic meetings
• 1917 CQI and AL Regional Quality Group
• Community Partner Collaborative Education
• Clinical Care Team Education Services

Publications



Publications Describing New Work Supported by the Core

1.     Althoff KN, Rebeiro PF, Hanna DB, Padgett D, Horberg MA, Grinsztejn B, Abraham AG, Hogg R, Gill MJ, Wolff MJ, Mayor A, Rachlis A, Williams C, Sterling TR, Kitahata MM, Buchacz K, Thorne JE, Cesar C, Cordero FM, Rourke SB, Sierra-Madero J, Pape JW, Cahn P, McGowan C, Kirk GD, Benson CA, Bosch RJ, Boswell S, Mayer KH, Grasso C, Harrigan P, Montaner JS, Cescon A, Samji H, Brooks JT, Gebo KA, Moore RD, Rodriguez B, Silverberg MJ, Goedert JJ, Jacobson LP, D'Souza G, Klein MB, Burchell AN, Hunter-Mellado RF, Deeks SG, Martin JN, Patel P, Saag MS, Mugavero MJ, Willig J, Eron JJ, Napravnik S, Crane HM, Drozd DR, Haas D, Bebawy S, Turner M, Justice AC, Dubrow R, Fiellin D, Gange SJ, Anastos K, McKaig RG, Freeman AM, Lent C, Van Rompaey SE, Crane HM, Drozd DR, Morton L, McReynolds J, Lober WB, Lau B, Zhang J, Jing J, Golub E, Modur S, Wong C, Hogan B, Tong W, Lin B, Reyes MW, Madero JS, Gotuzzo E; North American Aids Cohort Collaboration on Research and Design (NA-ACCORD) and Caribbean, Central and South America Network for Hiv Epidemiology (CCASAnet). A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts. J Int AIDS Soc. 2016 Apr 4;19(1):20707. doi: 10.7448/IAS.19.1.20707. PMID: 27049052 PMCID: PMC4821890

2.     Antiretroviral Therapy Cohort Collaboration (ART-CC); Canadian Observational Cohort Collaboration (CANOC); UK Collaborative HIV Cohort Study (UK CHIC); Collaboration of Observational HIV Epidemiological Research in Europe (COHERE). Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis. AIDS. 2016 Jan 28;30(3):503-13. doi: 10.1097/QAD.0000000000000941.  PMID: 26562844 PMCID: PMC4711384

3.     Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016 Nov 24;375(21):2037-2050. Epub 2016 Nov 9. doi: 10.1056/NEJMoa1608243  PMID: 27959728 PMCID: not found in PMC

4.     Batey DS, Whitfield S, Mulla M, Stringer KL, Durojaiye M, McCormick L, Turan B, Nyblade L, Kempf MC, Turan JM. Adaptation and Implementation of an Intervention to Reduce HIV-Related Stigma Among Healthcare Workers in the United States: Piloting of the FRESH Workshop. AIDS Patient Care STDS. 2016 Nov;30(11):519-527. doi: 10.1089/apc.2016.0223 PMID: 27849373 PMCID: PMC5116658

5.     Becker WC, Merlin JS, Manhapra A, Edens EL. Management of patients with issues related to opioid safety, efficacy and/or misuse: a case series from an integrated, interdisciplinary clinic. Addict Sci Clin Pract. 2016 Jan 28;11(1):3. doi: 10.1186/s13722-016-0050-0. PMID: 26818474  PMCID: PMC4730605

6.     Bengtson AM, Pence BW, Crane HM, Christopoulos K, Fredericksen RJ, Gaynes BN, Heine A, Mathews WC, Moore R, Napravnik S, Safren S, Mugavero MJ. Disparities in depressive symptoms and antidepressant treatment by gender and race/ethnicity among people living with HIV in the United States. PLoS One. 2016;11(8):e0160738. doi: 10.1371/journal.pone.0160738 PMID: 27513328 PMCID: PMC4981370

7.     Bengtson AM, Pence BW, Gaynes BN, Quinlivan EB, Heine AD, O’Donnell JK, Crane HM, Mathews WC, Moore RD, Westreich D, O’Cleirigh C, Christopoulos K, Mimiaga MJ, Mugavero MJ. Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care. J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):482-488. doi: 10.1097/QAI.0000000000001131.  PMID: 27668804 PMCID: PMC5085843

8.     Buchacz K, Lau B, Jing Y, Bosch R, Abraham AG, Gill MJ, Silverberg MJ, Goedert JJ, Sterling TR, Althoff KN, Martin JN, Burkholder G, Gandhi N, Samji H, Patel P, Rachlis A, Thorne JE, Napravnik S, Henry K, Mayor A, Gebo K, Gange SJ, Moore RD, Brooks JT, Kirk GD, Benson CA, Boswell S, Mayer KH, Grasso C, Hogg RS, Harrigan PR, Montaner JS, Cescon A, Carey JT, Rodriguez B, Horberg MA, Jacobson LP, D'Souza G, Klein MB, Rourke SB, Burchell AN, Hunter-Mellado RF, Deeks SG, Saag MS, Mugavero MJ, Willig J, Eron JJ, Kitahata MM, Crane HM, Drozd DR, Rebeiro PF, Haas D, Bebawy S, Turner M, Justice AC, Dubrow R, Fiellin D, Anastos K; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. J Infect Dis. 2016 Sep 15;214(6):862-72. doi: 10.1093/infdis/jiw085.  PMID: 27559122 PMCID: PMC4996145

9.     Butterfield TR, Hanna DB, Kaplan RC, Kizer JR, Durkin HG, Young MA, Nowicki MJ, Tien PC, Golub ET, Floris-Moore MA, Titanji K, Fischl MA, Heath SL, Martinson J, Crowe SM, Palmer CS, Landay AL, Anzinger JJ. Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease. AIDS. 2017 Jan 14;31(2):199-205. doi: 10.1097/QAD.0000000000001320.

PMID: 27835618

PMCID: not found in PMC

10.  Caniglia EC, Sabin C, Robins JM, Logan R, Cain LE, Abgrall S, Mugavero MJ, Hernandez-Diaz S, Meyer L, Seng R, Drozd DR, Seage GR 3rd, Bonnet F, Dabis F, Moore RR, Reiss P, van Sighem A, Mathews WC, Del Amo J, Moreno S, Deeks SG, Muga R, Boswell SL, Ferrer E, Eron JJ, Napravnik S, Jose S, Phillips A, Olson A, Justice AC, Tate JP, Bucher HC, Egger M, Touloumi G, Sterne JA, Costagliola D, Saag M, Hernán MA; Center for AIDS Research Network of Integrated Clinical Systems and the HIV-CAUSAL Collaboration. When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study. J Acquir Immune Defic Syndr. 2016 Jun 1;72(2):214-21. doi: 10.1097/QAI.0000000000000956. PMID: 26895294 PMCID: PMC4866894

11.  Cesar C, Koethe JR, Giganti MJ, Rebeiro P, Althoff KN, Napravnik S, Mayor A, Grinsztejn B, Wolff M, Padgett D, Sierra-Madero J, Gotuzzo E, Sterling TR, Willig J, Levison J, Kitahata M, Rodriguez-Barradas MC, Moore RD, McGowan C, Shepherd BE, Cahn P, Kirk GD, Benson CA, Bosch RJ, Boswell S, Grasso C, Mayer KH, Hogg RS, Harrigan PR, Montaner JS, Cescon A, Samji H, Brooks JT, Buchacz K, Gebo KA, Rodriguez B, D'Souza G, Horberg MA, Silverberg MJ, Thorne JE, Goedert JJ, Jacobson LP, Klein MB, Rourke SB, Burchell AN, Rachlis AR, Hunter-Mellado RF, Gill MJ, Deeks SG, Martin JN, Patel P, Saag MS, Mugavero MJ, Eron JJ, Crane HM, Drozd DR, Justice AC, Dubrow R, Fiellin D, Haas D, Bebawy S, Turner M, Gange SJ, Anastos K, McKaig RG, Justice AC, Freeman AM, Lent C, Van Rompaey SE, Crane HM, Drozd DR, Morton L, McReynolds J, Lober WB, Abraham AG, Lau B, Zhang J, Jing Y, Golub E, Modur S, Wong C, Liu B, Tong W, Hogan B, Reyes MW, Pape JW, Madero JS; Caribbean, Central and South America Network for HIV epidemiology (CCASAnet) and North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Health outcomes among HIV-positive Latinos initiating antiretroviral therapy in North America versus Central and South America. J Int AIDS Soc. 2016 Mar 18;19(1):20684. doi: 10.7448/IAS.19.1.20684. PMID: 26996992 PMCID: PMC4800379

12.  Chander G, Monroe AK, Crane HM, Hutton HE, Saag MS, Cropsey K, Eron JJ, Quinlivan EB, Geng E, Mathews WC, Boswell S, Rodriquez B, Ellison M, Kitahata MM, Moore RD, McCaul ME. HIV primary care providers--Screening, knowledge, attitudes and behaviors related to alcohol interventions. Drug Alcohol Depend. 2016 Apr 1;161:59-66. doi: 10.1016/j.drugalcdep.2016.01.015. PMID: 26857898  PMCID: PMC4841449

13.  Cholera R, Pence BW, Bengtson AM, Crane HM, Christopoulos K, Cole SR, Fredericksen R, Gaynes BN, Heine A, Mathews WC, Mimiaga MJ, Moore R, Napravnik S, O'Clerigh C, Safren S, Mugavero MJ. Mind the Gap: Gaps in Antidepressant Treatment, Treatment Adjustments, and Outcomes among Patients in Routine HIV Care in a Multisite U.S. Clinical Cohort. PLoS One. 2017 Jan 26;12(1):e0166435. doi: 10.1371/journal.pone.0166435. PMID: 28125593 PMCID: PMC5268441

14.  Cooper C, Naggie S, Saag M, Yang JC, Stamm LM, Dvory-Sobol H, Han L, Pang PS, McHutchison JG, Dieterich D, Sulkowski M. Successful Re-treatment of Hepatitis C Virus in Patients Coinfected With HIV Who Relapsed After 12 Weeks of Ledipasvir/Sofosbuvir. Clin Infect Dis. 2016 Aug 15;63(4):528-31. doi: 10.1093/cid/ciw349.  PMID: 27225242  PMCID: PMC4967607

15.  Crane HM, Fredericksen RJ, Church A, Harrington A, Ciechanowski P, Magnani J, Nasby K, Brown T, Dhanireddy S, Harrington RD, Lober WB, Simoni J, Safren SA, Edwards TC, Patrick DL, Saag MS, Crane PK, Kitahata MM. A Randomized Controlled Trial Protocol to Evaluate the Effectiveness of an Integrated Care Management Approach to Improve Adherence Among HIV-Infected Patients in Routine Clinical Care: Rationale and Design. JMIR Res Protoc. 2016 Oct 5;5(4):e156. doi: 10.2196/resprot.5492.  PMID: 27707688 PMCID: not found in PMC

16.  Crane HM, McCaul ME, Chander G, Hutton H, Nance RM, Delaney JA, Merrill JO, Lau B, Mayer KH, Mugavero MJ, Mimiaga M, Willig JH, Burkholder GA, Drozd DR, Fredericksen RJ, Cropsey K, Moore RD, Simoni JM, Christopher Mathews W, Eron JJ, Napravnik S, Christopoulos K, Geng E, Saag MS, Kitahata MM. Prevalence and Factors Associated with Hazardous Alcohol Use Among Persons Living with HIV Across the US in the Current Era of Antiretroviral Treatment. AIDS Behav. 2017 Mar 11. [Epub ahead of print] doi: 10.1007/s10461-017-1740-7. PMID: 28285434 PMCID: not found in PMC

17.  Crane HM, Nance RM, Delaney JA, Fredericksen RJ, Church A, Simoni JM, Harrington RD, Dhanireddy S, Safren SA, McCaul ME, Lober WB, Crane PK, Wilson IB, Mugavero MJ, Kitahata MM. A comparison of adherence timeframes using missed dose items and their associations with viral load in routine clinical care: Is longer better? AIDS Behav. 2017 Feb;21(2):470-480. doi: 10.1007/s10461-016-1566-8. PMID: 27714525 PMCID: PMC5290185

18.  Crane HM, Nance RM, Merrill JO, Hutton H, Chander G, McCaul ME, Mathews WC, Fredericksen R, Simoni JM, Mayer K, Mugavero MJ, Willig JH, Burkholder G, Drozd DR, Mimiaga M, Lau B, Kim HN, Cropsey K, Moore RD, Christopoulos K, Geng E, Eron JJ, Napravnik S, Kitahata MM, Saag MS, Delaney JA. Not all non-drinkers with HIV are equal: demographic and clinical comparisons among current non-drinkers with and without a history of prior alcohol use disorders. AIDS Care. 2017 Feb;29(2):177-184. doi: 10.1080/09540121.2016.1204418. PMID: 27482893 PMCID: not found in PMC

19.  Crane HM, Paramsothy P, Drozd DR, Nance RM, Delaney JA, Heckbert SR, Budoff MJ, Burkholder GA, Willig JH, Mugavero MJ, Mathews WC, Crane PK, Moore RD, Eron JJ, Napravnik S, Hunt PW, Geng E, Hsue P, Rodriguez C, Peter I, Barnes GS, McReynolds J, Lober WB, Crothers K, Feinstein M, Grunfeld C, Saag MS, Kitahata MM; Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) Cohort. Types of Myocardial Infarction Among Human Immunodeficiency Virus-Infected Individuals in the United States. JAMA Cardiol. 2017 Jan 4. [Epub ahead of print] doi: 10.1001/jamacardio.2016.5139. PMID: 28052152 PMCID: not found in PMC

20.  Crepaz N, Tang T, Marks G, Mugavero MJ, Espinoza L, Hall HI. Durable viral suppression and transmission risk potential among persons with diagnosed HIV infection: United States, 2012-2013. Clin Infect Dis. 2016 Oct 1;63(7):976-83. doi: 10.1093/cid/ciw418. PMID: 27358354 PMCID: PMC5021630

21.  Cropsey KL, Willig JH, Mugavero MJ, Crane HM, McCullumsmith C, Lawrence S, Raper JL, Mathews WC, Boswell S, Kitahata MM, Schumacher JE, Saag MS; CFAR Network of Integrated Clinical Systems. Cigarette smokers are less likely to have undetectable viral loads: results from four HIV Clinics. J Addict Med. 2016;10(1):13-9. doi: 10.1097/ADM.0000000000000172. PMID: 26656939 PMCID: PMC4733609

22.  Dionne-Odom J, Welty TK, Westfall AO, Chi BH, Ekouevi DK, Kasaro M, Tih PM, Tita AT. Factors Associated with PMTCT Cascade Completion in Four African Countries. AIDS Res Treat. 2016;2016:2403936. Epub 2016 Oct 31. doi: 10.1155/2016/2403936 PMID: 27872760  PMCID: PMC5107823

23.  Du VY, Bansal A, Carlson J, Salazar-Gonzalez JF, Salazar MG, Ladell K, Gras S, Josephs TM, Heath SL, Price DA, Rossjohn J, Hunter E, Goepfert PA. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J Immunol. 2016 Apr 15;196(8):3276-86. doi: 10.4049/jimmunol.1502411. PMID: 26983786 PMCID: PMC4821763

24.  Eaton EF, Tamhane AR, Burkholder GA, Willig JH, Saag MS, Mugavero MJ. Unanticipated Effects of New Drug Availability on Antiretroviral Durability: Implications for Comparative Effectiveness Research. Open Forum Infect Dis. 2016 Jun 16;3(2):ofw109. doi: 10.1093/ofid/ofw109.PMID: 27419181 PMCID: PMC4943538

25.  Eaton EF, Tamhane A, Saag M, Mugavero MJ, Kilgore ML. Cost considerations in the current antiretroviral era. AIDS. 2016 Sep 10;30(14):2115-9. doi: 10.1097/QAD.0000000000001120.PMID: 27088319 PMCID: not found in PMC

26.  Edwards JK, Cole SR, Lesko CR, Mathews WC, Moore RD, Mugavero MJ, Westreich D. An Illustration of Inverse Probability Weighting to Estimate Policy-Relevant Causal Effects. Am J Epidemiol. 2016 Aug 15;184(4):336-44. doi: 10.1093/aje/kwv339. PMID: 27469514 PMCID: PMC4983650

27.  Elopre L, Kudroff K, Westfall AO, Overton ET, Mugavero MJ. The right people, right places, and right practices: disparities in PrEP access among African American men, women and MSM in the deep south. J Acquir Immune Defic Syndr. 2017;74(1):56-59. doi: 10.1097/QAI.0000000000001165. PMID: 27552156 PMCID: not found in PMC

28.  Feinstein MJ, Nance RM, Drozd DR, Ning H, Delaney JA, Heckbert SR, Budoff MJ, Mathews WC, Kitahata MM, Saag MS, Eron JJ, Moore RD, Achenbach CJ, Lloyd-Jones DM, Crane HM. Assessing and Refining Myocardial Infarction Risk Estimation Among Patients With Human Immunodeficiency Virus: A Study by the Centers for AIDS Research Network of Integrated Clinical Systems. JAMA Cardiol. 2017 Feb 1;2(2):155-162. doi: 10.1001/jamacardio.2016.4494.  PMID: 28002550 PMCID: PMC5310962

29.  Fredericksen RJ, Tufano J, Ralston J, McReynolds J, Stewart M, Lober WB, Mayer KH, Mathews WC, Mugavero MJ, Crane PK, Crane HM. Provider perceptions of the value of same-day, electronic patient-reported measures for use in clinical HIV care. AIDS Care. 2016 Nov;28(11):1428-33. doi: 10.1080/09540121.2016.1189501. PMID: 27237187 PMCID: PMC5310959

30.  Gakumo CA, Raper JL, Cerice DK, Stand-Gravois MJ, Mugavero MJ. A qualitative study on health numeracy and patient-provider communication of laboratory numbers in older African Americans with HIV. J Assoc Nurses AIDS Care. 2016;27(6):826-834. doi: 10.1016/j.jana.2016.06.003. PMID: 27522144 PMCID: not found in PMC

31.  Gibbons LE, Fredericksen R, Merrill JO, McCaul ME, Chander G, Hutton H, Lober WB, Mathews WC, Mayer K, Burkholder G, Willig JH, Mugavero MJ, Saag MS, Kitahata MM, Edwards TC, Patrick DL, Crane HM, Crane PK. Suitability of the PROMIS alcohol use short form for screening in a HIV clinical care setting. Drug Alcohol Depend. 2016 Jul 1;164:113-9. doi: 10.1016/j.drugalcdep.2016.04.038. PMID: 27209223 PMCID: PMC4896136

32.  Günthard HF, Saag MS, Benson CA, del Rio C, Eron JJ, Gallant JE, Hoy JF, Mugavero MJ, Sax PE, Thompson MA, Gandhi RT, Landovitz RJ, Smith DM, Jacobsen DM, Volberding PA. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2016 Jul 12;316(2):191-210. doi: 10.1001/jama.2016.8900. PMID: 27404187 PMCID: PMC5012643

33.  Hanna DB, Lin J, Post WS, Hodis HN, Xue X, Anastos K, Cohen MH, Gange SJ, Haberlen SA, Heath SL, Lazar JM, Liu C, Mack WJ, Ofotokun I, Palella FJ, Tien PC, Witt MD, Landay AL, Kingsley LA, Tracy RP, Kaplan RC. Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men. J Infect Dis. 2017 Feb 12. [Epub ahead of print] doi: 10.1093/infdis/jix082. PMID: 28199691 PMCID: not found in PMC

34.  Hartzler B, Carlini BH, Newville H, Crane HM, Eron JJ, Geng EH, Mathews WC, Mayer KH, Moore RD, Mugavero MJ, Napravnik S, Rodriguez B, Donovan DM. Identifying HIV care enrollees at-risk for cannabis use disorder. AIDS Care. 2016 Dec 23:1-5. [Epub ahead of print] doi: 10.1080/09540121.2016.1271393.  PMID: 28006972
PMCID: not found in PMC

35.  Hel Z, Xu J, Denning WL, Helton ES, Huijbregts RPH, Heath SL, Overton ET, Christmann BS, Elson CO, Goepfert PA, Mestecky J. Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 Infection. PLoS Pathog. 13(1): e1006087. doi: 10.1371/journal.ppat.1006087.PMID: 28125732PMCID: PMC5268400

36.  Kay ES, Batey DS, Mugavero MJ. The HIV treatment cascade and care continuum: updates, goals, and recommendations for the future. AIDS Res Ther. 2016 Nov 8;13:35. eCollection 2016. doi: 10.1186/s12981-016-0120-0.PMID: 27826353 PMCID: PMC5100316

37.  Kim HN, Crane HM, Rodriguez CV, Van Rompaey S, Mayer KH, Christopoulos K, Napravnik S, Chander G, Hutton H, McCaul ME, Cachay ER, Mugavero MJ, Moore R, Geng E, Eron JJ, Saag MS, Merrill JO, Kitahata MM. The Role of Current and Historical Alcohol Use in Hepatic Fibrosis Among HIV-Infected Individuals. AIDS Behav. 2016 Dec 29. [Epub ahead of print] doi: 10.1007/s10461-016-1665-6.  PMID: 28035496 PMCID: not found in PMC

38.  Klein MB, Althoff KN, Jing Y, Lau B, Kitahata M, Lo Re V 3rd, Kirk GD, Hull M, Kim HN, Sebastiani G, Moodie EE, Silverberg MJ, Sterling TR, Thorne JE, Cescon A, Napravnik S, Eron J, Gill MJ, Justice A, Peters MG, Goedert JJ, Mayor A, Thio CL, Cachay ER, Moore R, Benson CA, Bosch RJ, Boswell S, Mayer KH, Grasso C, Hogg RS, Harrigan PR, Montaner JS, Samji H, Brooks JT, Buchacz K, Gebo KA, Rodriguez B, Horberg MA, Jacobsonc LP, D'Souza G, Rourke SB, Burchell AN, Rachlis AR, Hunter-Mellado RF, Deeks SG, Martin JN, Patel P, Brooks JT, Saag MS, Mugavero MJ, Willig J, Crane HM, Drozd DR, Haas D, Bebawy S, Turner M, Dubrow R, Fiellin D, Gange SJ, Anastos K, McKaig RG, Freeman AM, Lent C, Van Rompaey SE, Drozd DR, Morton L, McReynolds J, Lober WB, Abraham AG, Zhang J, Jing J, Golub E, Modur S, Wong C, Hogan B, Tong W, Liu B.; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Risk of End-Stage Liver Disease in HIV-Viral Hepatitis Coinfected Persons in North America From the Early to Modern Antiretroviral Therapy Eras. Clin Infect Dis. 2016 Nov 1;63(9):1160-1167. doi: 10.1093/cid/ciw531. PMID: 27506682 PMCID: PMC5064164

39.  Koethe JR, Jenkins CA, Lau B, Shepherd BE, Justice AC, Tate JP, Buchacz K, Napravnik S, Mayor AM, Horberg MA, Blashill AJ, Willig A, Wester CW, Silverberg MJ, Gill J, Thorne JE, Klein M, Eron JJ, Kitahata MM, Sterling TR, Moore RD; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada. AIDS Res Hum Retroviruses. 2016 Jan;32(1):50-8. doi: 10.1089/aid.2015.0147.  PMID: 26352511 PMCID: PMC4692122

40.  Koethe JR, Jenkins CA, Lau B, Shepherd BE, Wester W, Rebeiro PF, Silverberg MJ, Thorne JE, Gill J, Mayor AM, Willig A, Bosch R, Horberg MA, Justice AC, Sterling TR, Moore RD; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Higher Time-Updated Body Mass Index: Association With Improved CD4+ Cell Recovery on HIV Treatment. J Acquir Immune Defic Syndr. 2016 Oct 1;73(2):197-204. doi: 10.1097/QAI.0000000000001035. PMID: 27116044 PMCID: PMC5023455

41.  Lesko CR, Cole SR, Hall HI, Westreich D, Miller WC, Eron JJ, Li J, Mugavero MJ; CNICS Investigators. The effect of antiretroviral therapy on all-cause mortality, generalized to persons diagnosed with HIV in the USA, 2009-11. Int J Epidemiol. 2016 Feb;45(1):140-50. doi: 10.1093/ije/dyv352.PMID: 26772869 PMCID: PMC5013889

42.  Luo Z, Li Z, Martin L, Hu Z, Wu H, Wan Z, Kilby M, Heath SL, Huang L, Jiang W. Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression. PLoS One. 2017 Jan 11;12(1):e0167640. doi: 10.1371/journal.pone.0167640. PMID: 28076376 PMCID: PMC5226712

43.  Marks G, Patel U, Stirratt MJ, Mugavero MJ, Mathews WC, Giordano TP, Crepaz N, Gardner LI, Grossman C, Davila J, Sullivan M, Rose CE, OʼDaniels C, Rodriguez A, Wawrzyniak AJ, Golden MR, Dhanireddy S, Ellison J, Drainoni ML, Metsch LR, Cachay ER. Single Viral Load Measurements Overestimate Stable Viral Suppression Among HIV Patients in Care: Clinical and Public Health Implications. J Acquir Immune Defic Syndr. 2016 Oct 1;73(2):205-12. doi: 10.1097/QAI.0000000000001036. PMID: 27105049
PMCID: not found in PMC

44.  May MT, Vehreschild JJ, Trickey A, Obel N, Reiss P, Bonnet F, Mary-Krause M, Samji H, Cavassini M, Gill MJ, Shepherd LC, Crane HM, d'Arminio Monforte A, Burkholder GA, Johnson MM, Sobrino-Vegas P, Domingo P, Zangerle R, Justice AC, Sterling TR, Miró JM, Sterne JA, Boulle A, Stephan C, Chêne G, Costagliola D, Dabis F, Monforte AD, Del Amo J, Van Sighem A, Fätkenheuer G, Guest J, Haerry DH, Hogg R, Crane H, Smith C, Saag M, Teira R, Williams M, Ingle S; Antiretroviral Therapy Cohort Collaboration (ART-CC). Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study. Clin Infect Dis. 2016 Jun 15;62(12):1571-7. doi: 10.1093/cid/ciw183. PMID: 27025828 PMCID: PMC4885653

45.  Melvin AJ, Montepiedra G, Aaron L, Meyer WA 3rd, Spiegel HM, Borkowsky W, Abzug MJ, Best BM, Crain MJ, Borum PR, Graham B, Anthony P, Shin K, Siberry GK; P1063 Study Team. Safety and Efficacy of Atorvastatin in Human Immunodeficiency Virus-infected Children, Adolescents and Young Adults With Hyperlipidemia. Pediatr Infect Dis J. 2017 Jan;36(1):53-60. DOI: 10.1097/INF.0000000000001352. PMID: 27749649 PMCID: PMC5154931

46.  Merlin JS, Bulls HW, Vucovich LA, Edelman EJ, Starrels JL. Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: a systematic review. AIDS Care. 2016 Dec;28(12):1506-1515. doi: 10.1080/09540121.2016.1191612 PMID: 27267445  PMCID: PMC5053858

47.  Merlin JS, Young SR, Johnson MO, Saag M, Demonte W, Modi R, Shurbaji S, Anderson WA, Kerns R, Nair MJ, Kertesz S, Davies S, Turan JM. Using Patient Perspectives to Inform the Development of a Behavioral Intervention for Chronic Pain in Patients with HIV: A Qualitative Study. Pain Med. 2016 Jul 17. DOI: 10.1093/pm/pnw150. PMID: 27425186 PMCID: not found in PMC

48.  Metsch LR, Feaster DJ, Gooden L, Matheson T, Stitzer M, Das M, Jain MK, Rodriguez AE, Armstrong WS, Lucas GM, Nijhawan AE, Drainoni ML, Herrera P, Vergara-Rodriguez P, Jacobson JM, Mugavero MJ, Sullivan M, Daar ES, McMahon DK, Ferris DC, Lindblad R, VanVeldhuisen P, Oden N, Castellón PC, Tross S, Haynes LF, Douaihy A, Sorensen JL, Metzger DS, Mandler RN, Colfax GN, del Rio C. Effect of Patient Navigation With or Without Financial Incentives on Viral Suppression Among Hospitalized Patients With HIV Infection and Substance Use: A Randomized Clinical Trial. JAMA. 2016 Jul 12;316(2):156-70. doi: 10.1001/jama.2016.8914.  PMID: 27404184
PMCID: PMC5339876

49.  Monroe AK, Lau B, Mugavero MJ, Mathews WC, Mayer KH, Napravnik S, Hutton HE, Kim HS, Jabour S, Moore RD, McCaul ME, Christopoulos KA, Crane HC, Chander G. Heavy Alcohol Use Is Associated With Worse Retention in HIV Care. J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):419-425. doi: 10.1097/QAI.0000000000001083.  PMID: 27243904 PMCID: PMC5085857

50.  Moylan DC, Goepfert PA, Kempf MC, Saag MS, Richter HE, Mestecky J, Sabbaj S. Diminished CD103 (αEβ7) Expression on Resident T Cells from the Female Genital Tract of HIV-Positive Women. Pathog Immun. 2016 Fall-Winter;1(2):371-87. doi: 10.20411/pai.v1i2.166. Epub 2017 Jan 16. PMID: 28164171 PMCID: PMC5288734

51.  Mugavero MJ. Elements of the HIV Care Continuum: Improving Engagement and Retention in Care. Top Antivir Med. 2016 Oct/Nov;24(3):115-119. PMID: 27841983
PMCID: not found in PMC

52.  Muzny CA, Burkholder GA, Fry KR, Austin EL, Schwebke JR. Trichomonas vaginalis Nucleic Acid Amplification Testing at an Urban HIV Clinic. Sex Transm Dis. 2016 Aug;43(8):483-8. doi: 10.1097/OLQ.0000000000000479. PMID: 27419815 PMCID: not found in PMC

53.  Nance RM, Delaney JA, Golin CE, Wechsberg WM, Cunningham C, Altice F, Christopoulos K, Knight K, Quan V, Gordon MS, Springer S, Young J, Crane PK, Mayer KH, Mugavero MJ, Del Rio C, Kronmal RA, Crane HM. Co-calibration of two self-reported measures of adherence to antiretroviral therapy. AIDS Care. 2017 Apr;29(4):464-468. Epub 2016 Dec 2. doi: 10.1080/09540121.2016.1263721. PMID: 27910703 PMCID: PMC5291764

54.  Noorhasan M, Drozd D, Grunfeld C, Merrill J, Burkholder G, Mugavero MJ, Willig JH, Willig A, Cropsey KL, Mayer K, Blashill A, Mimiaga M, McCaul ME, Hutton H, Chander G, Matthews WC, Napravnik S, Eron JJ, Christopoulos K, Fredericksen R, Nance R, Delaney JC, Crane P, Saag M, Kitahata MM, Crane H. Associations between at-risk alcohol use, substance use, and smoking with lipohypertrophy and lipoatrophy among patients living with HIV. AIDS Res Hum Retroviruses. 2017 Jan 16. doi: 10.1089/AID.2015.0357. PMID: 28092168 PMCID: not found in PMC

55.  Overton ET, Tebas P, Coate B, Ryan R, Perniciaro A, Dayaram YK, De La Rosa G, Baugh BP. Effects of once-daily darunavir/ritonavir versus atazanavir/ritonavir on insulin sensitivity in HIV-infected persons over 48 weeks: results of an exploratory substudy of METABOLIK, a phase 4, randomized trial. HIV Clin Trials. 2016 Mar;17(2):72-7. doi: 10.1080/15284336.2016.1141468. PMID: 26917112 PMCID: PMC5020348

56.  Patel P, Bush T, Kojic EM, Overton ET, Henry K, Önen N, Rhame F, Conley L, Brooks JT, Fry A. Duration of Influenza Virus Shedding Among HIV-Infected Adults in the cART Era, 2010-2011. AIDS Res Hum Retroviruses. 2016 Dec;32(12):1180-1186. doi: 10.1089/AID.2015.0349. PMID: 27174191 PMCID: PMC5175434

57.  Payne GA, Overton ET. The hidden risk: Incorporating inflammation and HIV serostatus into coronary artery disease screening. J Nucl Cardiol. 2016 Nov 16. [Epub ahead of print] doi: 10.1007/s12350-016-0731-9. PMID: 27853986 PMCID: not found in PMC

58.  Saag MS, Westfall AO, Cole SR, Mathews WC, Drozd DR, Mayer KH, Burkholder GA, Kitahata M, Maiese EM; CFAR Network of Integrated Clinical Systems (CNICS). Brief Report: Factors Associated With the Selection of Initial Antiretroviral Therapy From 2009 to 2012. J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):60-64. doi: 10.1097/QAI.0000000000001168 PMID: 27552153 PMCID: PMC5140679

59.  Sabbaj S, Scanion N, Du VY, Wang Y, Tang J, Hunter E, Goepfert PA. Brief Report: Enhanced Allogeneic Cellular Responses to Mismatched HLA-B Antigens Results in More Efficient Killing of HIV Infected Cells. J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):493-7. doi: 10.1097/QAI.0000000000000901. PMID: 26588705
PMCID: PMC4788531

60.  Salazar-Gonzalez JF, Salazar MG, Tully DC, Ogilvie CB, Learn GH, Allen TM, Heath SL, Goepfert P, Bar KJ. Use of Dried Blood Spots to Elucidate Full-Length Transmitted/Founder HIV-1 Genomes. Pathog Immun. 2016 Spring;1(1):129-153. doi: 10.20411/pai.v1i1.116. PMID: 27819061 PMCID: PMC5096837

61.  Sangarlangkarn A, Merlin JS, Tucker RO, Kelley AS. Advance Care Planning and HIV Infection in the Era of Antiretroviral Therapy: A Review. Top Antivir Med. 2016 Dec-2017 Jan;23(5):174-80. PMID: 27398771 PMCID: not found in PMC

62.  Seghatol-Eslami VC, Dark HE, Raper JL, Mugavero MJ, Turan JM, Turan B. Brief Report: Interpersonal and Intrapersonal Factors as Parallel Independent Mediators in the Association Between Internalized HIV Stigma and ART Adherence. J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):e18-e22. DOI: 10.1097/QAI.0000000000001177.
PMID: 27926668 PMCID: PMC5147512

63.  Shacham E, Önen NF, Donovan MF, Rosenburg N, Overton ET. Psychiatric Diagnoses among an HIV-Infected Outpatient Clinic Population. J Int Assoc Provid AIDS Care. 2016 Mar-Apr;15(2):126-30. doi: 10.1177/2325957414553846. PMID: 25348798 PMCID: not found in PMC

64.  Shepherd BE, Liu Q, Mercaldo N, Jenkins CA, Lau B, Cole SR, Saag MS, Sterling TR. Comparing results from multiple imputation and dynamic marginal structural models for estimating when to start antiretroviral therapy. Stat Med. 2016 Oct 30;35(24):4335-4351. doi: 10.1002/sim.7007. PMID: 27264354  PMCID: PMC5048599

65.  Starrels JL, Peyser D, Haughton L, Fox A, Merlin JS, Arnsten JH, Cunningham CO. When human immunodeficiency virus (HIV) treatment goals conflict with guideline-based opioid prescribing: A qualitative study of HIV treatment providers. Subst Abus. 2016;37(1):148-53. doi: 10.1080/08897077.2015.1129391. PMID: 26860130
PMCID: PMC4859811

66.  Thompson M, Heath SL, Sweeton B, Williams K, Cunningham P, Keele BF, Sen S, Palmer BE, Chomont N, Xu Y, Basu R, Hellerstein MS, Kwa S, Robinson HL. DNA/MVA Vaccination of HIV-1 Infected Participants with Viral Suppression on Antiretroviral Therapy, followed by Treatment Interruption: Elicitation of Immune Responses without Control of Re-Emergent Virus. PLoS One. 2016 Oct 6;11(10):e0163164. doi: 10.1371/journal.pone.0163164. PMID: 27711228 PMCID: not found in PMC

67.  Trickey A, May MT, Vehreschild J, Obel N, Gill MJ, Crane H, Boesecke C, Samji H, Grabar S, Cazanave C, Cavassini M, Shepherd L, d'Arminio Monforte A, Smit C, Saag M, Lampe F, Hernando V, Montero M, Zangerle R, Justice AC, Sterling T, Miro J, Ingle S, Sterne JA; Antiretroviral Therapy Cohort Collaboration (ART-CC). Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy. PLoS One. 2016 Aug 15;11(8):e0160460. doi: 10.1371/journal.pone.0160460. PMID: 27525413  PMCID: PMC4985160

68.  Turan B, Budhwani H, Fazeli PL, Browning WR, Raper JL, Mugavero MJ, Turan JM. How Does Stigma Affect People Living with HIV? The Mediating Roles of Internalized and Anticipated HIV Stigma in the Effects of Perceived Community Stigma on Health and Psychosocial Outcomes. AIDS Behav. 2017 Jan;21(1):283-291. doi: 10.1007/s10461-016-1451-5. PMID: 27272742 PMCID: PMC5143223

69.  Turan B, Fazeli PL, Raper JL, Mugavero MJ, Johnson MO. Social support and moment-to-moment changes in treatment self-efficacy in men living with HIV: Psychosocial moderators and clinical outcomes. Health Psychol. 2016 Oct;35(10):1126-34. doi: 10.1037/hea0000356. PMID: 27089459 PMCID: PMC5033657

70.  Valera P, McClernon FJ, Burkholder G, Mugavero MJ, Willig J, O'Cleirigh C, Cropsey KL. A Pilot Trial Examining African American and White Responses to Algorithm-Guided Smoking Cessation Medication Selection in Persons Living with HIV. AIDS Behav. 2016 Dec 9. [Epub ahead of print] doi: 10.1007/s10461-016-1634-0. PMID: 27942999 PMCID: not found in PMC

71.  Van Wagoner N, Elopre L, Westfall AO, Mugavero MJ, Turan J, Hook EW. Reported church attendance at the time of entry into HIV care is associated with viral load suppression at 12 months. AIDS Behav. 2016 Mar 2. [Epub ahead of print] doi: 10.1007/s10461-016-1347-4. PMID: 26936149 PMCID: not found in PMC

72.  Vinikoor MJ, Sinkala E, Chilengi R, Mulenga L, Chi BH, Zyambo Z, Hoffmann CJ, Saag MS, Davies MA, Egger M, Wandeler G. Impact of antiretroviral therapy on liver fibrosis among HIV-infected adults with and without HBV coinfection in Zambia. Clin Infect Dis. 2017 Feb 4. [Epub ahead of print] doi: 10.1093/cid/cix122.  PMID: 28158504 PMCID: not found in PMC

73.  Willig ALOverton ET. Metabolic Complications and Glucose Metabolism in HIV Infection: A Review of the Evidence. Curr HIV/AIDS Rep. 2016 Oct;13(5):289-96. Review. doi: 10.1007/s11904-016-0330-z. PMID: 27541600 PMCID: not found in PMC

74.  Yang C, Crane HM, Cropsey K, Hutton H, Chander G, Saag M, McCaul ME. Implementation of Computer-delivered Brief Alcohol Intervention in HIV Clinical Settings: Who Agrees to Participate? J Addict Res Ther. 2016 Apr;7(2). doi: 10.4172/2155-6105.1000276. PMID: 27274904 PMCID: PMC4890715

*CFAR members are bolded




Contact Information




534A8472-ZF-9919-68082-1-001-003
                                              Pictured: Drs. Turner Overton, Greer Burkholder and Michael Mugavero


Director
Michael Mugavero, MD, MHSC
Email: mmugavero@uab.edu 

Co-Director
Greer A. Burkholder, MD, MSPH (Database and Informatics)
Email: gburkhol@uab.edu

Co-Director
Sonya L. Heath, MD (Specimen Repository)
Email: heaths@uab.edu

Co-Director
E. Turner Overton, MD (Education and Training)
Email: toverton@uab.edu 

Clinical Core Coordinator
Sarah Dougherty
Email: sarahdougherty@uabmc.edu 

University of Alabama at Birmingham
Community Care Building (CCB)
908 20th Street South
Birmingham AL 35294-2050
205-975-5667