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Core Developmental

Core B red2Since its inception in 1988, the Developmental Core has been an integral part of the UAB CFAR. The goal of the Developmental Core is to act as a mentoring, innovation and research integration platform that serves the CFAR members. As such, the Developmental Core is the primary steering tool for the CFAR to translate its vision into actual research. This is achieved by (i) a strong emphasis on mentoring of junior investigators, (ii) the initiation of targeted research collaborations through pilot awards and (iii), in conjunction with UAB Departments, the recruitment of faculty that support the vision of the CFAR.

The Developmental Core provides assistance, mentoring and funding to junior faculty and investigators new to the HIV/AIDS. Through the CFAR Developmental Grant and mentoring process the Developmental Core provides scientific feedback on proposed research programs to all investigators from experienced faculty. In addition, the Developmental core keeps UAB CFAR members informed of the latest areas of emphasis put forth by the NIH and other funding opportunities. Doing so not only ensures that UAB investigators remain relevant in the emerging areas of HIV research but also enables young investigators to become established in pertinent investigations critical to the future of the field.

Services


  • Research funding assistance to qualified junior investigators and those interested in new HIV research initiatives to fund high quality research proposals each year through the Developmental Grants Awards program.
    • The Request for Applications for the 2013-2014 CNIHR (Creative and Novel Ideas in HIV Research) proposals is now open (deadline for concepts, October 16th, 2013). See www.cnihr.org for more information and to download the RFA
    • The Request for Applications for the 2012-2013 AIDS Malignancy Pilot Awards Program is now closed (effective Dec 2012). Contact the CFAR Administrative Offices or Developmental Core Director for more information.
    • Travel and Pilot funding is available to UAB investigators, students and trainees to conduct projects in Durban, South Africa at the Kwazulu-Natal Research Institute for Tuberculosis and HIV / KRITH. See UAB's Global Health, ID and Vaccines Initiative website for RFAs and more information. A pilot funding RFA is now active with a deadline for proposals of October 7th, 2013.
  • Scientific guidance through a mentoring program to each of the developmental grant awardees.
    • A comprehensive mentoring program is currently under development by the CFAR. Check back for more information as this program develops.
  • Facilitates investigational Research Groups (IRGs) to address new research initiatives by collaborations between researchers across diverse disciplines.
    • IRGs are created at the discretion of the CFAR Executive Committee as emerging areas of research are identified.  Information will be posted as these groups are initiated. Funding is also made available to these groups through a competitive process.
  • Services to facilitate grant submission and review.
    • These services include assistance with grant preparation including financial planning and helping to establish links between the PI and appropriate experts at UAB for Letters of Collaboration (especially Core Directors and facilities available to CFAR members)

Publications


RECENT PUBLICATIONS RESULTING FROM CFAR DEVELOPMENTAL AWARDS:

Merino A, Sabbaj S, Easlick J, Goepfert PA, Kaslow RA and Tang J. HLA-B signal peptides differentially influences HLA-E- and natural killer cell-mediated cytotoxicity against HIV-infected target cells. Clin. Exp. Immunol. 2013; in press.

Bhaskar AM, Mehta M, Parikh P, Kumar A, Bhavesh N, Singh A. Imaging real time redox potential of mycobacterium tuberculosis using redox sensitive green fluorescent protein2013;in preparation.

Vance DE, Fazeli PL, Gakumo CA. The impact of neuropsychological performance on everyday functioning between older and younger adults with and without HIV. J Assoc Nurses AIDS Care. 2013;24(2):112-25. PMID: 22943982; PMCID: PMC3515709.

Koethe JR, Blevins M, Bosire C, Nyirenda C, Kabagambe EK, Mwango A, Kasongo W, Zulu I, Shepherd BE, Heimburger DC. Self-reported dietary intake and appetite predict early treatment outcome among low-BMI adults initiating HIV treatment in sub-Saharan Africa. Public Health Nutr. 2013;16(3):549-58. PMID: 22691872.

Kurundkar D, Srivastava RK, Chaudhary SC, Ballestas ME, Kopelovich L, Elmets CA, Athar M. Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicol Appl Pharmacol. 2013;266(2):233-44. PMID: 23147569; PMCID: PMC3534787.

Vlach J, Saad JS. Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers. Proc Natl Acad Sci U S A. 2013;110(9):3525-30. PMID: 23401539; PMCID: PMC3587261.

Speer A, Shrestha TB, Bossmann SH, Basaraba RJ, Harber GJ, Michalek SM, Niederweis M, Kutsch O, Wolschendorf F. Copper-boosting compounds: a novel concept for antimycobacterial drug discovery. Antimicrob Agents Chemother. 2013;57(2):1089-91. PMID: 23254420; PMCID: PMC3553712.

King DF, Siddiqui AA, Buffa V, Fischetti L, Gao Y, Stieh D, McKay PF, Rogers P, Ochsenbauer C, Kappes JC, Arts EJ, Shattock RJ. Mucosal tissue tropism and dissemination of HIV-1 subtype B acute envelope-expressing chimeric virus. J Virol. 2013;87(2):890-9. PMID: 23135721; PMCID: PMC3554101.

Gakumo CA, Vance D, Moneyham L, Deupree JP, Estrada CA. Health numeracy and health literacy within the context of management of patients with human immunodeficiency virus. Nursing: Research and Reviews. 2013;3:23-31.

Fazeli PL, Ross LA, Vance DE, Ball K. The relationship between computer experience and computerized cognitive test performance among older adults. J Gerontol B Psychol Sci Soc Sci. 2013;68(3):337-46. PMID: 22929395; PMCID: PMC3627654.

Duverger A, Wolschendorf F, Zhang M, Wagner F, Hatcher B, Jones J, Cron RQ, van der Sluis RM, Jeeninga RE, Berkhout B, Kutsch O. An AP-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infection. J Virol. 2013;87(4):2264-77. PMID: 23236059; PMCID: PMC3571467.

Mentoring


Optimal mentoring of young students and faculty is a common goal of a number of UAB organizations. CFAR is currently developing a collaborative program with the UAB Center for Clinical and Translational Science (CCTS) and the Department of Medicine to leverage the existing mentoring resources and programming that provides direct mentoring of new scientists.

The CFAR Mentoring Program will be open to all graduate/medical students, residents, post-docs/fellows and new faculty (Instructors and Assistant Professors) who are working in the area of HIV at UAB. The services provided will include matching mentors with mentees and conflict resolution services, as needed. Mentees will be matched with a research mentor as well as a career mentor. The roles of career mentors will differ in that the research mentor is expected to have expertise within their research area while the career mentor may not be matched based upon similar clinical or research interest but would rather serve as someone who provides guidance in career development (e.g., obtaining the first faculty position, contract negotiation, finding career/life balance, etc.).

The UAB CCTS has developed mentoring tools that provide both mentors and mentees at UAB with access to guidance and tools such as mentoring contracts (viewable on CCTS Training Academy website: www.uab.edu/ccts). We use these mentoring tools, as well as other pertinent resources to facilitate mentoring at UAB as we develop this new resource. 

Contact Information


Core B cropped                                                                            Pictured: Drs. Karen Cropsey and Paul Goepfert


Director
Paul Goepfert, MD
Email:  paulg@uab.edu
205-975-5667

Co-Director
Karen Cropsey, PsyD
Email: kcropsey@uab.edu
205-975-4204

University of Alabama at Birmingham
CCB 328
908 20th Street South
Birmingham, AL 35294

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