To meet the challenges of HIV/AIDS research in prevention, pathogenesis, drug discovery and the natural history in the treatment era, it has been necessary to create a new CFAR Genomics Core. The overall goal of the core is to provide investigators access to cutting-edge genomics resources and methodologies designed to facilitate and strengthen the quality of genetic, genomic, and molecular studies in HIV/AIDS related research. The Genomics Core emphasis on new genomic services, coupled with the microbiome resource and the companion bioinformatics services, provides CFAR investigators with unique resources that will allow for avenues of research in alignment with the 4 pillars of the CFAR scientific mission of prevention, pathogenesis, drug discovery and the natural history in the treatment area era.
CFAR investigators will now have access to genome genotyping, gene expression, and methylation arrays, low and high throughput custom genotyping and gene expression, and both standard and next generation sequencing (NGS). A new component has been developed by the core that will provide microbiome analytical capabilities. This component currently provides 16S rRNA gene microbiome analysis and in the future its services will include microbial metagenome, transcriptome and possibly virome analysis. The Core provides guidance for microbiome analysis and the selection of genomic assays and analyses. The specialized knowledge of the core leadership makes this Genomics Core unique in providing not only methodological but also content expertise. The provision of bioinformatics resources and support to help investigators analyze and understand the datagenerated by the genomics core will continue to be a priority through the CFAR Molecular and Genetics Bioinformatics Facility (MGBF).
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Pictured: Drs. Michael Crowley, Casey Morrow and Elliot Lefkowitz
Casey Morrow, PhD
Casey Morrow, PhD
Contact for Next Generation Sequencing and Microarrays
Michael Crowley, PhD
Contact for the CFAR Molecular and Genetic Bioinformatics Facility (MGBF)
Elliot Lefkowitz, PhD
Contact for CFAR DNA Sequencing:
University of Alabama at Birmingham
720 20th Street South
Kaul Human Genetics Building, Rooms 406-412
Birmingham, AL 35233