The success of modern antiretroviral therapy has converted HIV from a near-certain death sentence to a chronic manageable condition that allows the majority of patients in care to live near-Revised Red Ribbon 2017normal life spans.  As a result, scientific agendas have moved from development of more ARV drugs similar to those available now to development of new drugs that have fewer long-term adverse effects, those that can be given at expanded intervals (e.g., monthly), and development of agents that can cure HIV.  Clinical scientific agendas have also morphed into the study of the Behavioral Epidemiology and Intervention Research, with a focus on Basic Sciences to Impact Clinical Outcomes and management of multiple comorbid conditions, long-term ARV toxicities, and issues related to aging, as our patient population grows older. HIV Population Health Prevention and Treatment Research efforts continue to focus on development, testing and identification of novel HIV vaccines, microbicides, and pre-exposure prophylaxis (PrEP).  Community Engagement efforts include novel “Seek, Test and Treat” strategies based on new knowledge about controlling transmission, addressing stigma and the continuum of care through strong community involvement and meaningful partnerships.  Ensuring service to these 4 overarching pillars of scientific research unifies our purpose and aligns our research goals with those of the National AIDS Strategy and the HIV scientific community.

Promoting Collaborative Research at UAB-
Employing Interdisciplinary Research Groups (IRGs) and Scientific Working Groups (SWGs) serves as critical management tools to create new, dynamic programs that align emerging trends in HIV research with our stated mission and research goals. Such groups are initiated by our Leadership Committee and are supported by Core B developmental funding. These groups capitalize on areas of excellence at our institution by encouraging interdisciplinary collaboration among investigators who have not previously worked with each other, or within an area of scientific focus, and may include investigators outside the field of HIV/AIDS research.  Join our mailing list for information on such opportunities.

Access to Unique National Research Networks and Development Opportunities-
The UAB CFAR supports the national CFAR mission through oversight and organization to NIH-funded research networks and faculty development programs including the Alabama Clinical Trials Unit (A-CTU), Women’s Interagency HIV Study (WIHS) site (UAB-UMMC), CNICS, NA-ACCORD, and CNIHR pilot awards program for those new to HIV research.   Contact us for more information about accessing these resources or use the tabs below to learn more. 

1917 Clinic Cohort

The UAB 1917 Clinic Cohort is a prospective cohort study established in 1992 that includes HIV positive individuals who receive primary and subspecialty care at the University of Alabama at Birmingham (UAB) 1917 Clinic. Situated in the US Deep South, the UAB 1917 Clinic Cohort provides unique insights into a region bearing a disproportionate burden of the domestic HIV epidemic. The multidisciplinary investigative team also partners with national and international investigators playing a pivotal role in large-scale, multi-site collaborative cohort studies.
The success of the 1917 Clinic Cohort over the years is directly attributable to the talent and enthusiasm of the Cohort Team that includes individuals from a diverse array of backgrounds who work together on a daily basis to collectively advance the scientific agenda.
For more information:

Alabama Clinical Trials Unit

ACTU21The UAB CFAR is committed to providing the most modern, up to date, therapeutic and prevention interventions to patients and at-risk populations in our State. A hallmark of this work has been collaborative, highly interactive, multidisciplinary research that bridges work from the laboratory to the clinic. In 2005, CFAR formed the Alabama-Clinical Trials Unit (A-CTU), a partnership of UAB investigators dedicated to the conduct of high-impact HIV-related studies in a resource-poor region of the United States. The A-CTU was recently refunded for another 7 years in 2013.  The A-CTU conducts studies associated with three clinical trials networks, including the  HVTN (HIV Vaccine Trials Network), the ACTG (AIDS Clinical Trials Group), and the MTN (Microbicides Trials Network). Trials conducted by the A-CTU are housed on the main campus of the UAB School of Medicine, within the facilities of the UAB 1917 Clinic. For more information on clinical studies, visit the UAB 1917 Clinic website or the Alabama Vaccine Research Clinic (AVRC) website.  


The CFAR Network of Integrated Clinical Systems (CNICS) project is the first electronic medical records-bLogoased resource network poised to integrate clinical data from the large and diverse population of HIV-infected persons in the modern HAART era who are receiving care at one of the US-funded Center for AIDS Research (CFAR) sites.

As a clinic-based research network, CNICS directly reflects the outcomes of clinical decisions and management options made daily in the care of HIV infected individuals. Unlike data collected in structured interviews or through retrospective medical record review, CNICS captures a broader range of information associated with the rapidly changing course of HIV disease management through a collection of data at the point-of-care. A single, fully integrated database links each patient record to a diverse collection of clinical, behavioral, and biological data. The flexibility of this consortium enables CNICS to address scientific questions that cannot be answered through any other collaborative cohorts.  Each CNICS site utilizes a point-of-care electronic health record (EHR) system to organize, record, and plan for the care of all HIV+ patients, including those who would not typically be eligible for clinical trials or more traditional, selective HIV cohorts.  CNICS capitalizes upon these existing EHR systems, which at most sites have captured clinical data since 1995, and combine them into a single research enterprise.  Funded by an R24 infrastructure award in 2006, CNICS has evolved to become a fully mature platform that can support translational, clinical, and behavioral research projects from any investigator who desires to use the platform as part of their funded research projects or as part of a pilot project to gain further research support.

For more information, please check the CNICS website.


Dr. Michael Saag is Co-PI for The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). This network is part of the International Databases to Evaluate AIDS (IEDEA) RFA.

The NA-ACCORD is designed to be widely representative of HIV care in the United States and Canada. The network includes investigators who have a high level of scientific expertise and clinical experience and has an efficient structure for harmonization of data and the conduct of analyses.


WIHS UAB FINALThe Women's Interagency HIV Study, WIHS, began in 1993 to investigate the impact of HIV infection on women in the United States. It is the largest and longest ongoing U.S. study of HIV-infected women.  The study receives support from the National Institute of Allergy and Infectious Diseases, the National Cancer Institute, the National Institute of Child Health and Human Development, the National Center for Research Resources, and the National Institute onWIHS UMMC FINAL Drug Abuse.

The original WIHS clinical sites are located in and around 6 cities in the US: Bronx, NY; Brooklyn, NY; Washington, DC; Los Angeles, CA; San Francisco, CA; and Chicago, IL. Four new southern sites have just been added to the study, including a site in Birmingham AL. This site is a collaborative effort between the University of Alabama at Birmingham (UAB) CFAR and the University of Mississippi Medical Center (UMMC). The WIHS data management and coordinating center are in Baltimore, MD. Each consortium is headed by a principal investigator, is affiliated with local research institutes to see study participants, and has its own Community Advisory Board.


The Creative and Novel Ideas in HIV Research (CNIHR) program is an innovative new pilot program co-sponsored by the International AIDS Society, the Office of AIDS Research and the NIAID.  The intentCNIHR SMALL of this program is to attract both international and U.S.-based early stage investigators from outside the field of HIV as well as researchers involved in other aspects of HIV/AIDS research to help address key scientific questions. The UAB, UW and UCSF CFARs manage this program.  Requests for applications are announced annually in July. Eligible applicants include junior investigators who have either completed their terminal research degree (e.g. PhD, DVM, MMed + Postdoc) or MD or medical residency within the last ten years, and who have a faculty or equivalent position (e.g. assistant professor, senior lecturer, etc.) in good standing at an academic institution or have a comparable position in a not for profit organization or institution with a primary mission of research. Both domestic and international investigators are encouraged to apply. Mentorship by a CFAR investigator is required as a condition of the award. The award terms are up to 2 years in length. Awards are generally funding at up to $150,000 Direct Cost per year, (the amount of the award will vary depending on the proposal).  Funding is also provided for awardees to attend future CROI meetings during the proposed period of research. Visit the program website for more information on open RFAs and to download the program RFA.