David M. Bedwell, Ph.D.
The mission of the Animal Models Core is to generate and provide murine models for study of cystic fibrosis.
Mouse line generation by both oocyte micro-injection and by embryonic stem cell gene targeting technologies are assisted by the Core. The Animal Models Core also establishes breeding colonies of CF mice, and genotypes and provides these to UAB investigators. In addition, the Core furnishes electrophysiology tests of CFTR activation, including murine nasal potential difference assays and intestinal short circuit current measurements.
The Core was established in 2002 as a result of a P50 award from the National Institute of Diabetes and Digestive and Kidney Diseases. Core users are typically associated with the Cystic Fibrosis Research Center, but there is no limitation on who may access the Core.
Core Director: David M. Bedwell, Ph.D.
Cystic Fibrosis (CF) Animal Models Core