Cystic Fibrosis Workshop Series
Examples of interdisciplinary workshop presentations given during the past 2 years include the following:
Kevin Kirk, Ph.D., Cellular, Developmental, and Integrative Biology
"Gain of function mutations as tools to study CFTR channel gating"
Nancy Wooldridge, Associate Prof, Pediatrics
"Nutritional status and disease severity in pre-adolescent patients with Cystic Fibrosis"
Steve Rowe, M.D., Pulmonary Medicine
"Functional anatomic defects of the CF airway"
Christie Brouillette, Ph.D., Chemistry
"P-glycoprotein, and CFTR domain studies: What we have learned about interdomain cooperativity, responses
to ligand binding and inferences for CFTR"
Wook Joon Chung, Ph.D., Neurobiology
"Availability of F508del CFTR for small molecule correction"
Jim Collawn, Ph.D., Cellular, Developmental, and Integrative Biology
"Disabled-2 (Dab2), CHIP, and c-Cbl facilitate the down-regulation of cell surface ΔF508 CFTR in human
airway epithelial cells"
John Lowman, Ph.D., Physical Therapy
"Exercise testing and prescription for persons with CF"
Zsuzsa Bebok, M.D., Cellular, Developmental, and Integrative Biology
"Highlights of the 2013 ECFS basic science conference"
J. Edwin Blalock, Ph.D., Pulmonary Medicine
"An abberant Leukotriene A4 Hydrylase-PGP pathway in the pathogenesis of COPD"
Karen Bernard, Ph.D., Pulmonary Medicine
"Clusterin control of lung fibroblast phenotypes and matrix remodeling"
Chris Mueller, Ph.D., Pediatrics
"CFTR dysfunction and its immune consequences"
Tom Harris, M.D., Pulmonary Medicine
"Peribronchiolar and parenchymal remodeling in CF lung disease"
Susan Birket, Postdoctoral Fellow, Pulmonary Medicine
"The mucociliary clearance defect of the cystic fibrosis rat"
Dave Bedwell, Ph.D., Microbiology
"Nonsense suppression approaches to treat genetic diseases"
Sylvie Mrug, Ph.D., Psychology
"Spiritual coping, well-being and health in youth with CF"
Tomasz Szul, Postdoctoral Fellow, Pulmonary Medicine
"Toll-Like receptor 4 mediates Prolyl Endopeptidase (PE) release from airway epithelia via exosomes"
Lianwu Fu, Ph.D., Cellular, Developmental, and Integrative Biology
"Regulation of ΔF508 CFTR stability on the cell surface"
Michael Stalvey, M.D., Pediatrics
"Use of anabolic agents in cystic fibrosis: Effects on growth, puberty and quality of life. Where are we now?"
Eugene Chang, M.D., Otolaryngology, University of Iowa
"Translational research - what we can learn from a pig and a patient about CF sinusitis"
Wei Wang, Ph.D., Cellular, Developmental, and Integrative Biology
"Electrostatic interaction between coupling helix 1 and 4 of CFTR promotes channel opening"
James Londino, Ph.D., Post-doctoral Scholar, University of Pittsburgh
"Influenza infection inhibits CFTR expression and activity"
David M. Bedwell, Ph.D., Microbiology
"Why is the validity of PTC124 as a nonsense suppression drug still being questioned?"
Mary Ann Accavitti-Loper, Ph.D., Genetics
"The search for conformationally-dependent Mabs"
S. Vamsee Raju, B.Pharm, PhD, Pulmonary, Allergy and Critical Care Medicine
"Acquired CFTR dysfunction in ferret model of chronic bronchitis"
LaCrecia J. Britton, RN, MSN, CPNP-AC/PC and Hector Gutierrez, M.D., UAB/COA Cystic Fibrosis Center
"Sustained improvement in nutritional outcomes in the COA/UAB Pediatric CF Center after a quality
Venkateshwar Mutyam, Ph.D., Pulmonary Medicine
"A novel screen to identify clinically available agents that promote suppression of CFTR nonsense mutations"
"A review of the 2014 National Cystic Fibrosis Meetings"
Chad Steele, Ph.D., Medicine
"Immunopathogenesis vs. immunoprotection after pulmonary exposure to environmental mold"
Marilyn Crain, M.D., Pediatrics and Microbiology, and Evida Dennis, MD-PhD student
"Streptococcus pneumoniae in CF sputum: serotypes, biofilms and CFTR deficient mice"
Gang Liu, M.D., Ph.D, Pulmonary, Allergy & Critical Care Medicine
"Glycolysis in lung fibrosis and inflammation"
Amit Gaggar, M.D., M.P.H., Pulmonary, Allergy & Critical Care Medicine
"The strange translational tale of MMP-9 in cystic fibrosis"
Marty Solomon, M.D., Pulmonary, Allergy & Critical Care Medicine
"Methods to interrogate mechanisms of altered ciliary dynamics and mucus transport"
Michael Stalvey, M.D., Pediatrics - Endocrinology
"Pathogenesis and mortality of CFRD: yesterday, today and tomorrow"
Namasivayam Ambalavanan, M.D., Pediatrics - Neonatology
"Normal and abnormal lung development and its relevance to adult lung diseases"
Tamas Jilling, M.D., Pediatrics - Neonatology
"Why would you want to study the rold of platelet-activating factor (PAF) in CF pathogenesis?"
Vedrana Bali, M.D., Ph.D., Cellular, Developmental & Integrative Biology
"Synonymous but not the same. A synonymous codon change alters ΔF508 CFTR corrector sensitivity"
Kathryn Oliver, Ph.D. Candidate (Mentor: Eric J. Sorscher)
"Ribosomal P Stalk pertubation rescues F508del CFTR maturational arrest"
Zhengrong (Wendy) Yang, Ph.D., Center for Biophysical Sciences/Engineering
"Interactions and cooperativity between P-glycoprotein structual domains determined by thermal unfolding"
Rui-Ming Liu, M.D., Ph.D., Pulmonary, Allergy & Critical Care Medicine
"Therapeutic potential of a small molecular PAI-1 inhiibitor for chronic asthma"
Note: Other regularly scheduled workshops (not shown above) include 1) rehearsal sessions for UAB talks in preparation for NACFC, 2) CF journal club, 3) review of the European CF meetings (provided by Drs. Bebok and Rowe), and 4) discussions regarding grant opportunities from NIH (RFAs, PAs. etc.).