NO modulation of Cl- secretion

Charles Falany, Ph.D., Pharmacology

Induction of SULT1E1 in CF Hepatocytes: Is there a role in the regulation of ß-Estradiol?

Laura Vogtle, Ph.D., Occupational Therapy

Challenges for adolescents with cystic fibrosis - the transition to adult care providers

Rafal Bartoszewski, Ph.D., Cell Biology

Misfolding of the human ΔF508 CFTR mRNA decreases translation rate

Hector Gutierrez, M.D., Pediatrics

The science of process management and scientific knowledge: comparing their impact on clinical outcomes in cystic fibrosis. The UAB experience.

Steven Rowe, M.D., Medicine

Detecting rescued CFTR - Lessons from clinical trials

Bakhrom Berdiev, M.D., Ph.D., Cell Biology

CFTR and ENaC: From single channel to single cell

James F. Collawn, Ph.D., Cell Biology

Chemical chaperones and low temperature correction of ΔF508 CFTR

Amit Gaggar, M.D., Ph.D., Medicine

A Possible Role of Matrix-Derived Neutrophil Chemoattractants in Chronic Allograft Rejection Post-Lung Transplantation

Gang Liu, Ph.D., Medicine

MicroRNA, innate immunity, and macrophage function

Brad Woodworth, M.D., Surgery

Primary nasal epithelial cell culture for CF research

Chad Steele, Ph.D., Microbiology

Aspergillus fumigatus: an emerging pathogen in CF lung disease?

Edward Postlethwait, Ph.D., Environmental Health Sciences

Lung surface antioxidant biochemistry: potential paradoxes during oxidant stress and effects on lung development

Wook Joon Chung, Ph.D., Neurobiology

Detection of surface CFTR by affinity labeling

Jingyu Guo, Genetics

Genome-wide screening and characterization of modifiers of CFTR trafficking and function in yeast cell model

Michele Kong, M.D., Pediatrics

Neutrophil derived matrix metalloproteinases and their inhibitors in pediatric viral respiratory infection

Mary Ann Accavitti-Loper, Ph.D., Genetics

Production of Monoclonal Reagents to CFTR:  A Work in Progress

Karen Bernard, Ph.D., Physiology & Biophysics

Inhibition of CFTR Mediated Cl- Current by Neutrophil Elastase

Percy Wang, Ph.D.

Southern Research Institute

Lung sound study using wavelet analysis

Michelle V. Fanucchi, Ph.D., Environmental Health Sciences

Effects of Environmental Toxicants on Postnatal Lung Development

Lacrecia Britton, RN

UAB/CHS Cystic Fibrosis Center

Self-Management Support: How to Help Patients Help Themselves

John Hartman, M.D., Genetics

Genome-wide epistasis analysis in S. cerevisiae to identify regulators of ABC-transporter biogenesis

John Lowman, Ph.D., Physical Therapy

Aerobic and resistive exercise training for an acute CF exacerbation

Erik Schwiebert, Ph.D.

Discovery BioMed

Novel CF Drug Discovery Programs based upon First Principles of Scientific Inquiry

John Paul Clancy, M.D., Pediatrics

Development of Intestinal Current Measurements for studies of CFTR in native human tissue

John C. Kappes, Ph.D., Medicine, Hematology & Oncology

Large Scale Production of CFTR in Mammalian Cells

Stephen Barnes, Ph.D., Pharmacology

Mass spectrometry in the study of the biochemistry of membrane proteins

Louisa Pyle, Genetics

Developing CFTR Modulator Signatures

Chiquito Crasto, Ph.D., Genetics          

Managing the research knowledge of Cystic Fibrosis

Meredith Preuss, Ph.D., Medicine, Gene Therapy

Helper Dependent Adenovirus for Long-term Gene Expression

Tom Harris, M.D., Pediatric Pulmonology

TGF-b1 in CF lung disease: More questions than answers

Larry DeLucas, O.D., Ph.D., Optometry

CFTR Crystallization: Challenges and Future Strategies

Marilyn Crain, M.D., Pediatrics

Mucoid Streptococcus pneumoniae in the CF Lung

Carol Dashiff, Ph.D., Nursing

Middle Adolescents with CFRD and their Parents: Self-Management and Implications for Care

Justin Roth, Ph.D., Human Gene Therapy

Lung-targeted gene delivery with a neutrophil-binding adenovirus

Mark Dransfield, M.D., Medicine

Acquired CFTR dysfunction in COPD

Guangyu Wang, Ph.D., Physiology & Biophysics

"Inhibition mechanisms of the R domain in the CFTR channel

Christie Brouillette, Ph.D., Chemistry

Temperature- and chemical chaperone-rescue of (F508del)CFTR - a possible molecular mechanism from biophysical studies on the NBD1 domain

Julie McDougal, RRT, MAE, Pediatrics

Communicating Clearly To CF Patients And Families

Graeme Bolger, M.D., Medicine, Hematology

Regulation of cAMP in the CFTR Local Environment

Greg Clines, M.D., Medicine, Endocrinology

New Role for CFTR in Bone

Akhil Maheshwari, M.D., Pediatrics

Gut Mucosal Inflammation in Cystic Fibrosis

J. Edwin Blalock, Ph.D., Medicine, Pulmonary and Critical Care

 Leukotriene A4 Hydrolase: An Anti-Inflammatory Role for a Pro-Inflammatory Enzyme

Becky Christian, Ph.D., RN, School of Nursing

 An Intervention to Improve Quality of Life in School-age Children with Cystic Fibrosis

Virginia Anderson, MS, RD, Clinical Nutritionist, Children's Hospital and

Nancy Wooldridge, MS, RD, Co-Director, Pediatric Pulmonary Center 

The Relationship between Suboptimal Serum- 25-Hydroxyvitamin D Levels and Cystic Fibrosis Related Diabetes

Elizabeth Sztul, Ph.D., Cell Biology

Preventing protein aggregation as a therapeutic tool

Aubrey E. Hill, Ph.D., Computer & Information Science

Investigating CFTR Introns

Michelle McClure, Genetics

Palmitoylation and Other Post-Translational Modifications of CFTR with Relevance to Gating and Processing

David Bedwell, Ph.D., Microbiology

Approaches to restore protein expression and function from nonsense alleles in CF and other diseases

Zsuzsanna Bebok, M.D., Cell Biology

The Ghost of ΔF508: The silent SNP (Ile507ATT) speaks

Wei Wang, Ph.D., Physiology & Biophysics

Thermal Induced Irreversible Channel Inactivation of ∆F508-CFTR and its prevention by constitutively active cytosolic loop mutations

Tomasz Szul, Ph.D., Medicine, Division of Pulmonary/Allergy/Critical Care

Genetic Regulation and Expression of Leukotriene A4 Hydrolase: Possible Implications to Chronic Neutrophilic Inflammation

Mike Stalvey, M.D., Pediatrics/Cell Biology/Gene Therapy Center

CF Bone Disease: Insights into a Growing Problem

Viktoria Havasi, M.D., Cystic Fibrosis Research Center

Developing a CFTR deficient polycystic kidney mouse model

Trenton Schoeb, DVM, Ph.D., Genetics

Analytical Pathology: Turning Phenotypes into Numbers

Carmel McNicholas-Bevensee, Ph.D., Physiology & Biophysics

Electrophysiological Approaches to Studying CFTR Regulation in Primary and Model Cell Lines

Steve Aller, Ph.D., Pharmacology & Toxicology

Probing a Mechanism for Correcting the Major CF Defect (F508del): Is There an Actual Binding Pocket?

Note:  In addition to the examples shown above, separate CF Workshops to discuss the North American CF Conference (NACFC) are conducted annually by Dr. E. Sorscher. Other regularly scheduled workshops (not shown above) include 1) rehearsal sessions for UAB talks in preparation for NACFC,  2) CF journal club, 3) review of the European CF meetings (provided by Drs. Bebok and Rowe), and 4) discussions regarding grant opportunities from NIH (RFAs, PAs. etc.).