Cystic Fibrosis Workshop Series
Examples of interdisciplinary workshop presentations given during the past 2 years include the following:
Carmel McNicholas-Bevensee, Ph.D., Cellular, Developmental, and Integrative Biology
"Electrophysiological approaches to studying CFTR regulation in primary and model cell lines"
Steve Aller, Ph.D., Pharmacology & Toxicology
"Proving a mechanism for correcting the major CF defect (F508del): Is there an actual binding pocket?"
Xin Xu, M.D., Ph.D., Pulmonary Medicine
"Prolyl endopeptidase expression in human CF airway epithelial cells and its regulation by LPS"
Ahmed Lazrak, Ph.D., Anesthesiology
"A look at how ENaC might exacerbate cystic fibrosis pathogenesis in the lung"
Katherine Tuggle, Graduate Trainee, Environmental Health Sciences
"Lifetime episodic ozone exposure alters pulmonary development in wild-type and CFTR-/- mice"
Rui-Ming Liu, D.A.B.T., Ph.D., Pulmonary Medicine
"Oxidative stress, plasminogen activator inhibitor-1, and lung fibrosis"
Graeme Bolger, M.D., Medicine
"Mechanisms of action of the CFTR Activator VX770"
Chad Steele, Ph.D., Pulmonary Medicine
"Dectin-1 and immunopathogenesis during fungal allergy"
Tom Broker, Ph.D., Biochemistry & Molecular Genetics
"Recurrent respiratory papillomatosis: Cause, characterization, control, challenges"
James Londino, Graduate Trainee, Cellular, Developmental, and Integrative Biology
"Influenza Matrix protein 2 alters CFTR expression and activity"
S. Vamsee Raju, Ph.D., Pulmonary Medicine
"Acquired systemic CFTR defects in cigarette smokers"
Michele Kong, M.D., Pediatrics
"Matrix metalloproteinase dysregulation in pediatric RSV-induced respiratory failure"
Tomasz Szul, Ph.D., Postdoctoral Fellow, Pulmonary Medicine
"Unconventional secretion of prolyl endopeptidase from airway epithelial cells upon LPS stimulation"
Sarah Ingersoll, Ph.D. and Julie Laval, Ph.D. Candidate, Children's Center for Research, Emory University
"Metabolic and functional plasticity of neutrophils in CF patients"
Venkateshwar Mutyam, Postdoctoral Candidate, University of Dayton
"Aquaporin water channels: A cell's version of indoor plumbing"
Kevin Kirk, Ph.D., Cellular, Developmental, and Integrative Biology
"Gain of function mutations as tools to study CFTR channel gating"
Nancy Wooldridge, Associate Prof, Pediatrics
"Nutritional status and disease severity in pre-adolescent patients with Cystic Fibrosis"
Steve Rowe, M.D., Pulmonary Medicine
"Functional anatomic defects of the CF airway"
Christie Brouillette, Ph.D., Chemistry
"P-glycoprotein, and CFTR domain studies: What we have learned about interdomain cooperativity, responses to ligand binding and inferences for CFTR"
Wook Joon Chung, Ph.D., Neurobiology
"Availability of F508del CFTR for small molecule correction"
Jim Collawn, Ph.D., Cellular, Developmental, and Integrative Biology
"Disabled-2 (Dab2), CHIP, and c-Cbl facilitate the down-regulation of cell surface ΔF508 CFTR in human airway epithelial cells"
John Lowman, Ph.D., Physical Therapy
"Exercise testing and prescription for persons with CF"
Zsuzsa Bebok, M.D., Cellular, Developmental, and Integrative Biology
"Highlights of the 2013 ECFS basic science conference"
J. Edwin Blalock, Ph.D., Pulmonary Medicine
"An abberant Leukotriene A4 Hydrylase-PGP pathway in the pathogenesis of COPD"
Karen Bernard, Ph.D., Pulmonary Medicine
"Clusterin control of lung fibroblast phenotypes and matrix remodeling"
Chris Mueller, Ph.D., Pediatrics
"CFTR dysfunction and its immune consequences"
Tom Harris, M.D., Pulmonary Medicine
"Peribronchiolar and parenchymal remodeling in CF lung disease"
Susan Birket, Postdoctoral Fellow, Pulmonary Medicine
"The mucociliary clearance defect of the Cystic Fibrosis rat"
Dave Bedwell, Ph.D., Microbiology
"Nonsense suppression approaches to treat genetic diseases"
Sylvie Mrug, Ph.D., Psychology
"Spiritual coping, well-being and health in youth with CF"
Tomasz Szul, Postdoctoral Fellow, Pulmonary Medicine
"Toll-Like receptor 4 mediates Prolyl Endopeptidase (PE) release from airway epithelia via exosomes"
Lianwu Fu, Ph.D., Cellular, Developmental, and Integrative Biology
"Regulation of ΔF508 CFTR stability on the cell surface"
Michael Stalvey, M.D., Pediatrics
"Use on anabolic agents in cystic fibrosis: Effects on growth, puberty and quality of life. Where are we now?"
Eugene Chang, M.D., Otolaryngology, University of Iowa
"Translational research - what we can learn from a pig and a patient about CF sinusitis"
Wei Wang, Ph.D., Cellular, Developmental, and Integrative Biology
"Electrostatic interaction between coupling helix 1 and 4 of CFTR promotes channel opening"
Note: In addition to the examples shown above, separate CF Workshops to discuss the North American CF Conference (NACFC) are conducted annually by Dr. E. Sorscher. Other regularly scheduled workshops (not shown above) include 1) rehearsal sessions for UAB talks in preparation for NACFC, 2) CF journal club, 3) review of the European CF meetings (provided by Drs. Bebok and Rowe), and 4) discussions regarding grant opportunities from NIH (RFAs, PAs. etc.).