Mohammad Athar, Ph.D.

 

 

atharMohammad Athar, Ph.D.
University of Alabama at Birmingham
VH 509
1530 3RD AVE S
BIRMINGHAM AL 35294-0019

 

Office: (205)934-7554
mathar@uab.edu

 

 




Education

B.Sc.      1975. Chemistry. Lucknow University, Lucknow, India.
M.Sc.      1977. Inorganic Chemistry. Lucknow University, Lucknow, India.
M. Phil.   1978. Coordination Chemistry. Aligarh Muslim University, Aligarh, India.
Ph.D.      1980. Coordination Chemistry. Aligarh Muslim University, Aligarh, India.

 

Academic Affiliations

Professor and Vice-Chair for Basic Research:   Department of Dermatology
Senior Scientist:   UAB Comprehensive Cancer Center
Co-Director:   UAB Skin Disease Research Center
Faculty Member:   Graduate School, University of Alabama at Birmingham
Adjunct Senior Research Scientist:   Columbia University College of Physicians and Surgeons, NY

 

Selected Publications

Chaudhary SC, Singh T, Talwelkar SS, Srivastava RK, Arumugam A, Weng Z, Elmets CA, Afaq F, Kopelovich L, Athar M. Erb-041, an estrogen receptor beta agonist inhibits skin photocarcinogenesis in SKH-1 hairless mice by down-regulating WNT signaling pathway. Cancer Prev Res (Phila). 2013 Dec 19.


Pal HC, Sharma S, Strickland LR, Agarwal J, Athar M, Elmets CA, Afaq F. Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways. PLoS One. 2013 Oct 4;8(10):e77270.


Srivastava RK, Li C, Chaudhary SC, Ballestas ME, Elmets CA, Robbins DJ, Matalon S, Deshane JS, Afaq F, Bickers DR, Athar M. Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):879-87.

Li C, Srivastava RK, Elmets CA, Afaq F, Athar M. Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein. Biochem Biophys Res Commun. 2013 Sep 6;438(4):607-12.

Elmets CA, Athar M. Milestones in photocarcinogenesis. J Invest Dermatol. 2013 Jul 1;133(E1):E13-7.

Pal HC, Sharma S, Elmets CA, Athar M, Afaq F. Fisetin inhibits growth, induces G₂ /M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation. Exp Dermatol. 2013 Jul;22(7):470-5.

Katiyar SK, Athar M. Grape seeds: ripe for cancer chemoprevention. Cancer Prev Res (Phila). 2013 Jul;6(7):617-21.

Li C, Weng Z, Doran SF, Srivastava RK, Afaq F, Matalon S, Athar M. Chlorine induces the unfolded protein response in murine lungs and skin. Am J Respir Cell Mol Biol. 2013 Aug;49(2):197-203.

Kaylani SZ, Xu J, Srivastava RK, Kopelovich L, Pressey JG, Athar M. Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model. Biochem Biophys Res Commun. 2013 Jun 14;435(4):557-61

Kurundkar D, Srivastava RK, Chaudhary SC, Ballestas ME, Kopelovich L, Elmets CA, Athar M. Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicol Appl Pharmacol. 2013 Jan 15;266(2):233-44.

Ahmad N, Athar M. Introduction to the special issue honoring Professor David R. Bickers. Photochem Photobiol. 2012 Sep-Oct;88(5):1035-6.

Arumugam A, Walsh SB, Xu J, Afaq F, Elmets CA, Athar M. Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs. Biochem Biophys Res Commun. 2012 Aug 24;425(2):177-81.

Kim H, Casta A, Tang X, Luke CT, Kim AL, Bickers DR, Athar M, Christiano AM. Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling. PLoS One. 2012;7(6):e39691.

Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, Athar M, Shimamura M, Bhandari V, Aprahamian C, Dimmitt RA, Serra R, Ohis RK. TGF-Beta(2) suppresses cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology, 2011; 140: 242-53.

Kim KH, Back JH, Zhu Y, Arbesman J, Athar M, Kopelovich L, Kim AL, Bickers DR. Resveratrol targets transforming growth factor-beta2 signaling to block UV-induced tumor progression. J Invest. Dermatol., 2011; 131: 195-202.

Xu J, Timares L, Heilpern C, Weng Z, Li C, Xu H, Pressey JG, Elmets CA, Kopelovich L, Athar M. Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. Cancer Res., 2010; 70: 6566-76.

Elmets CA, Athar M. Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans. Cancer Prev. Res. (Phil, PA), 2010; 3: 8-11.


See Pubmed for further publications for Dr. M. Athar


 Active Grant Support

NIH/NCI R01
Project entilted "Inhibiting multiple molecular targets for preventing non-melanoma skin cancer"
Principle Investigator: Mohammad Athar, Ph.D.
Period: 03/04/2011 - 02/28/2016

NIH/NIAMS/NCI R21
Project entitled "Therapeutic intervention of lewisite-mediated cutaneous blistering-inflammation"
Principle Investigator: Mohammad Athar, Ph.D.
Period:  09/15/12-08/31/14