Nabiha Yusuf, Ph.D.

 

yusufwebUniversity of Alabama at Birmingham
VH 566 A
1530 3rd Avenue South
Birmingham, AL 35294-0019

Office: (205)934-7432
nabiha@uabmc.edu

 

 

 Education and Academic Affiliation

Department:    Dermatology
Faculty Appointment:          Assistant Professor, School of Medicine; Associate Scientist, Comprehensive Cancer Center, UAB
Title:   Assistant Professor
Graduate Education:   Ph.D., Aligarh Muslim University, Aligarh, India, Biochemistry
Research Fellowship:   Post-doctoral Fellow, Dermatology, UAB, 2001-2005

 

Academic Appointments:

Bacteriologist:

 

New Delhi Tuberculosis Center, New Delhi, India, 2000

Assistant Professor:

 

Department of Dermatology, School of Medicine, UAB, 2009-till date

Scientist:

  

Veterans Administration Medical Center, Birmingham, AL 2006-till date

 

Research Interests

Our laboratory is involved in evaluating the effect of environmental influences such as chemical carcinogens and ultraviolet radiation on the skin immune system. The focus of our research is on the role of innate immunity in the development of skin carcinogenesis. Toll-like receptors (TLRs), one component of innate immunity, are intricately associated with a number of dermatologic conditions. We have found that the innate immune system mediates through Toll like receptor-4 (TLR4) signaling to activate the cell mediated adaptive immune response against chemically induced tumors. TLR4 signaling had a protective effect against 7,12-dimethylbenz(a)anthracene (DMBA) induced skin cancer in certain strains of mich which develop cell mediated immune response to this chemical carcinogen. We are currently in the process of evaluating the role of the innate immune system in ultraviolet B (UVB) radiation induced skin cancer. The mechanisms by which UVB radiation influences cell mediated immune responses have been the subject of extensive investigation. However, there is little information on the role of innate immunity in this process. Our recent experiments suggest that certain components of innate immunity, especially TLR4, may play an important role in photoimmunosuppression. Currently, we are investigating whether the resistance of TLR4 gene knockout mice to UVB-induced immunosuppression has implications for photocarcinogenesis. The ultimate goal of these studies will be to define the role of TLR4 in the development of immune suppression and tumor development that occurs following UV radiation. This may allow us to identify genetic loci that are involved in these processes and to develop immunopreventive and immunotherapeutic approaches toward them.

 

For a list of Dr. Yusuf's publications, visit pubmed.